Abstract：
:Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, and MKN74. PTE showed a dose-dependent inhibition of cell proliferation, sphere-forming ability, and stem cell marker expression in all three cell lines. Furthermore, the cells treated with PTE showed an increase in mitochondrial membrane potential and an increase in mitochondrial oxidative stress and lipid peroxide. Upon concurrent treatment with vitamin E, N-acetyl-L-cysteine, and PTE, the PTE-induced mitochondrial oxidative stress and growth inhibition were suppressed. These findings indicate that PTE induces oxidative stress in cancer cells, suppresses stemness, and inhibits proliferation. These antitumor effects of PTE are considered to be useful in cancer treatment.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mori S,Kishi S,Honoki K,Fujiwara-Tani R,Moriguchi T,Sasaki T,Fujii K,Tsukamoto S,Fujii H,Kido A,Tanaka Y,Luo Y,Kuniyasu Hdoi
10.3390/ijms21249347subject
Has Abstractpub_date
2020-12-08 00:00:00issue
24issn
1422-0067pii
ijms21249347journal_volume
21pub_type
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