Abstract：
:Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DCs usually denotes conventional DCs (cDCs). Skin contains a unique DC network mainly composed of embryo precursor-derived epidermal Langerhans cells (LCs) and bone marrow-derived dermal cDCs, which can be further classified into type 1 (cDC1) and type 2 (cDC2) subsets. Psoriasis is a chronic inflammatory skin disease, which is principally mediated by IL-23/IL-17 cytokine axis. In the psoriatic skins, DCs are prominent cellular sources for TNF-α and IL-23, and the use of blocking antibodies against TNF-α and IL-23 leads to a significant clinical improvement in psoriatic patients. Recent elegant human and mouse studies have shown that inflammation-induced inflammatory DCs, LCs, dermal cDC2, and monocyte-derived DCs are pivotal DC subsets in psoriatic inflammation. Thus, targeting specific pathogenic DC subsets would be a potential strategy for alleviating and preventing DC-derived IL-23-dependent psoriatic inflammation and other inflammatory dermatoses in the future.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kim TG,Kim SH,Lee MGdoi
10.3390/ijms19010042subject
Has Abstractpub_date
2017-12-23 00:00:00issue
1issn
1422-0067pii
ijms19010042journal_volume
19pub_type
杂志文章,评审abstract：:Anthraquinones (AQs) and phenolic compounds are important phytochemicals that are biosynthesized in cell suspension cultures of Polygonum multiflorum. We wanted to optimize the effects of plant growth regulators (PGRs), media, sucrose, l-glutamine, jasmonic acid (JA), and salicylic acid (SA) for the production of phyt...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17111912
更新日期：2016-11-16 00:00:00
abstract：:Determination of the thermal characteristics and temperature-dependent rheological properties of the magnetorheological elastomers (MREs) is of paramount importance particularly with regards to MRE applications. Hitherto, a paucity of temperature dependent analysis has been conducted by MRE researchers. In this study,...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms20030746
更新日期：2019-02-10 00:00:00
abstract：:The 12-oxo-phytodienoic acid reductases (OPRs), which belong to the old yellow enzyme (OYE) family, are flavin mononucleotide (FMN)-dependent oxidoreductases with critical functions in plants. Despite the clear characteristics of growth and development, as well as the defense responses in Arabidopsis, tomato, rice, an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-04-18 00:00:00
abstract：:Collaterals are unique blood vessels present in the microcirculation of most tissues that, by cross-connecting a small fraction of the outer branches of adjacent arterial trees, provide alternate routes of perfusion. However, collaterals are especially susceptible to rarefaction caused by aging, other vascular risk fa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153608
更新日期：2019-07-24 00:00:00
abstract：:The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prev...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-06-29 00:00:00
abstract：:Aegista chejuensis and Aegista quelpartensis (Family-Bradybaenidae) are endemic to Korea, and are considered vulnerable due to declines in their population. The limited genetic resources for these species restricts the ability to prioritize conservation efforts. We sequenced the transcriptomes of these species using I...
journal_title：International journal of molecular sciences
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abstract：:Alterations of the β-adrenergic signalling, structural remodelling, and electrical failure of T-tubules are hallmarks of heart failure (HF). Here, we assess the effect of β-adrenoceptor activation on local Ca(2+) release in electrically coupled and uncoupled T-tubules in ventricular myocytes from HF rats. We employ an...
journal_title：International journal of molecular sciences
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更新日期：2016-09-03 00:00:00
abstract：:miRNAs have been widely investigated in terms of cell proliferation and differentiation. However, little is known about their effects on bird growth. Here we characterized the promoter of miR-206 in chicken and found that the preferable promoter was located in 1200 bp upstream of pri-miR-206. In this region, many key ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-04-14 00:00:00
abstract：:The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating the i...
journal_title：International journal of molecular sciences
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更新日期：2019-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-11-12 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-23 00:00:00
abstract：:MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been impli...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms131013414
更新日期：2012-10-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15034049
更新日期：2014-03-06 00:00:00
abstract：:Myoblasts, the contractile cells of skeletal muscle, have been invaluable for fundamental studies of muscle development and clinical applications for muscle loss. A major limitation to the myoblast-based therapeutic approach is contamination with non-contractile fibroblasts, which overgrow during cell expansion. To ov...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112242
更新日期：2017-10-30 00:00:00
abstract：:Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,随机对照试验
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020749
更新日期：2021-01-13 00:00:00
abstract：:The objectives of this study were to evaluate the binding behavior of Cu(II) and Eu(III) with water extractable organic matter (WEOM) in soil, and assess the competitive effect of the cations. Excitation-emission matrix (EEM) fluorescence spectrometry was used in combination with parallel factor analysis (PARAFAC) to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160714464
更新日期：2015-06-25 00:00:00
abstract：:The relationships among 55 wheat accessions (47 accessions collected from Iran and eight accessions provided by the Institute of Plant Biology of the University of Zurich, Switzerland) belonging to eight species carrying A genome (Triticum monococcum L., T. boeoticum Boiss., T. urartu Tumanian ex Gandilyan, T. durum D...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms11114309
更新日期：2010-11-02 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-01-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2010-01-25 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-07-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-12-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-09-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150814220
更新日期：2014-08-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms13044807
更新日期：2012-01-01 00:00:00
abstract：:Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062109
更新日期：2020-03-19 00:00:00
abstract：:Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanog...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms160818384
更新日期：2015-08-07 00:00:00
abstract：:The physiological and pathological roles of nascent amyloid beta (Aβ) monomers are still debated in the literature. Their involvement in the pathological route of Alzheimer's Disease (AD) is currently considered to be the most relevant, triggered by their aggregation into structured oligomers, a toxic species. Recentl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218295
更新日期：2020-11-05 00:00:00
abstract：:MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the prolif...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131216053
更新日期：2012-11-28 00:00:00
