Perineural dexmedetomidine attenuates inflammation in rat sciatic nerve via the NF-κB pathway.

Abstract:

:Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-inflammatory cytokines IL-6 and TNF-α. In this study, we established a rat model that simulates a clinical surgical procedure to investigate the anti-inflammatory effect of perineural administration of dexmedetomidine and the underlying mechanism. Dexmedetomidine reduced the sciatic nerve levels of IL-6 and TNF-α at both the mRNA and protein level. Dexmedetomidine also inhibited the translocation of activated NF-κB to the nucleus and the binding activity of NF-κB. The anti-inflammatory effect is confirmed to be dose-dependent. Finally, pyrrolidine dithiocarbamate also reduced the levels of IL-6 and TNF-α and the activation of NF-κB. In conclusion, dexmedetomidine inhibited the nuclear translocation and binding activity of activated NF-κB, thus reducing inflammatory cytokines.

journal_name

Int J Mol Sci

authors

Huang Y,Lu Y,Zhang L,Yan J,Jiang J,Jiang H

doi

10.3390/ijms15034049

subject

Has Abstract

pub_date

2014-03-06 00:00:00

pages

4049-59

issue

3

issn

1422-0067

pii

ijms15034049

journal_volume

15

pub_type

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