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A Review: Proteomics in Nasopharyngeal Carcinoma.

Abstract：

:Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis early stages of NPC would be highly useful to improve this situation. Proteomics is widely used in NPC for searching biomarkers and comparing differentially expressed proteins. In this review, an overview of proteomics with different samples related to NPC and common proteomics methods was made. In conclusion, identical proteins are sorted as follows: Keratin is ranked the highest followed by such proteins as annexin, heat shock protein, 14-3-3σ, nm-23 protein, cathepsin, heterogeneous nuclear ribonucleoproteins, enolase, triosephosphate isomerase, stathmin, prohibitin, and vimentin. This ranking indicates that these proteins may be NPC-related proteins and have potential value for further studies.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Chen ZT,Liang ZG,Zhu XD

doi

10.3390/ijms160715497

subject

Has Abstract

pub_date

2015-07-08 00:00:00

pages

15497-530

issue

7

issn

1422-0067

pii

ijms160715497

journal_volume

16

pub_type

杂志文章,评审

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