Abstract：
:The molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have identified MITOL (mitochondrial ubiquitin ligase: also known as MARCH5) localized on the mitochondrial outer membrane and previously reported that it is an important regulator of mitochondrial dynamics and mitochondrial quality control. In this review, we describe the pathological aspects of MITOL revealed through functional analysis and its potential as a drug discovery target.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Shiiba I,Takeda K,Nagashima S,Yanagi Sdoi
10.3390/ijms21113781subject
Has Abstractpub_date
2020-05-27 00:00:00issue
11issn
1422-0067pii
ijms21113781journal_volume
21pub_type
杂志文章,评审abstract：:In this communication, lipase A from Candida antarctica (CALA) was immobilized by covalent bonding on magnetic nanoparticles coated with chitosan and activated with glutaraldehyde, labelled CALA-MNP, (immobilization parameters: 84.1% ± 1.0 for immobilization yield and 208.0 ± 3.0 U/g ± 1.1 for derivative activity). CA...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-06-08 00:00:00
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更新日期：2020-03-18 00:00:00
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更新日期：2015-03-06 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-08-21 00:00:00
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更新日期：2016-12-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071719
更新日期：2019-04-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061573
更新日期：2018-05-25 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms13089785
更新日期：2012-01-01 00:00:00
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更新日期：2020-07-16 00:00:00
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更新日期：2020-03-23 00:00:00
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更新日期：2019-01-07 00:00:00
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更新日期：2020-09-05 00:00:00
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更新日期：2019-07-12 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-05-19 00:00:00
abstract：:Sunflower (Helianthus annuus L.) oil remains under-utilised albeit one of the major seed oils produced world-wide. Moreover, the high oleic sunflower varieties make the oil attractive for applications requiring high temperature processes and those targeting the C=C double bond functionality. Herein an overview of the ...
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更新日期：2008-08-01 00:00:00
