Abstract：
:Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain⁻gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota⁻gut⁻brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain⁻gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Liang S,Wu X,Hu X,Wang T,Jin Fdoi
10.3390/ijms19061592subject
Has Abstractpub_date
2018-05-29 00:00:00issue
6issn
1422-0067pii
ijms19061592journal_volume
19pub_type
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