CPP-Assisted Intracellular Drug Delivery, What Is Next?

Abstract:

:For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, thereby denying their clinical potential to become potent anti-cancer drugs. By taking the advantage of the unique cell-translocation property of these short peptides, various payloads of proteins, nucleic acids, or even nanoparticle-based carriers were delivered into all cell types with unparalleled efficiency. However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects. In view of these challenges, we present herein a review of the new designs of CPP-linked vehicles and strategies to achieve highly effective yet less toxic chemotherapy in combating tumor oncology.

journal_name

Int J Mol Sci

authors

Ye J,Liu E,Yu Z,Pei X,Chen S,Zhang P,Shin MC,Gong J,He H,Yang VC

doi

10.3390/ijms17111892

subject

Has Abstract

pub_date

2016-11-14 00:00:00

issue

11

issn

1422-0067

pii

ijms17111892

journal_volume

17

pub_type

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