Nuclear Functions of the Tyrosine Kinase Src.

Abstract:

:Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors.

journal_name

Int J Mol Sci

authors

Bagnato G,Leopizzi M,Urciuoli E,Peruzzi B

doi

10.3390/ijms21082675

subject

Has Abstract

pub_date

2020-04-11 00:00:00

issue

8

issn

1422-0067

pii

ijms21082675

journal_volume

21

pub_type

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