Abstract：
:Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease (ESRD) and is therefore a major burden on the healthcare system. Patients with DKD are highly susceptible to developing cardiovascular disease, which contributes to increased morbidity and mortality rates. While progress has been made to inhibit the acceleration of DKD, current standards of care reduce but do not eliminate the risk of DKD. There is growing appreciation for the role of inflammation in modulating the process of DKD. The focus of this review is on providing an overview of the current status of knowledge regarding the pathologic roles of inflammation in the development of DKD. Finally, we summarize recent therapeutic advances to prevent DKD, with a focus on the anti-inflammatory effects of newly developed agents.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Matoba K,Takeda Y,Nagai Y,Kawanami D,Utsunomiya K,Nishimura Rdoi
10.3390/ijms20143393subject
Has Abstractpub_date
2019-07-10 00:00:00issue
14issn
1422-0067pii
ijms20143393journal_volume
20pub_type
杂志文章,评审abstract：:Aqueous solutions of isovaline and its precursor molecule, 5-ethyl-5-methylhydantoin, were irradiated with ultraviolet and γ-ray photons, to evaluate their structural stability against space radiation. The degree of photolysis was measured and irradiation products were identified using chiral, reversed-phase and ion-e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13011006
更新日期：2012-01-01 00:00:00
abstract：:There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the si...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18081658
更新日期：2017-07-30 00:00:00
abstract：:Several studies have shown the importance of Extracellular Vesicles (EVs) in the intercellular communication between tumour and resident cells. Through EVs, tumour cells can trigger cell-signalling molecules and shuttle exogenous information to target cells, thus promoting spread of the disease. In fact, many processe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20194805
更新日期：2019-09-27 00:00:00
abstract：BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010227
更新日期：2019-12-28 00:00:00
abstract：:The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030678
更新日期：2017-03-22 00:00:00
abstract：:Up to 30-50% of patients with locally advanced prostate cancer (PCa) undergoing radiotherapy (RT) experience biochemical recurrence (BCR). The immune system affects the RT response. Immunogenetics could define new biomarkers for personalization of PCa patients' treatment. The aim of this study is to define the immunog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092082
更新日期：2019-04-27 00:00:00
abstract：:Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060900
更新日期：2016-06-08 00:00:00
abstract：:p-Sulfonatocalixarenes are a special class of water soluble macrocyclic molecules made of 4-hydroxybenzenesulfonate units linked by methylene bridges. One of the main features of these compounds relies on their ability to form inclusion complexes with cationic and neutral species. This feature, together with their wat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023140
更新日期：2013-02-04 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of the β-amyloid peptides and intracellular neurofibrillary tangles and associates with progressive declines in memory and cognition. Several genes play important roles and regulate enzymes that produce a pathological accumulation of β...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21041327
更新日期：2020-02-16 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD gene function and its ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050787
更新日期：2016-05-21 00:00:00
abstract：:Pulses are the main source of protein and minerals in the vegetarian diet. These are primarily cultivated on marginal lands with few inputs in several resource-poor countries of the world, including several in South Asia. Their cultivation in resource-scarce conditions exposes them to various abiotic and biotic stress...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20122971
更新日期：2019-06-18 00:00:00
abstract：:Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder and is presently untreatable. Previous studies using animal models have suggested mitochondrial damage and programmed cell death to be involved with ARHL. Thus, we further investigated the pathophysiologic role of mitochondria a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072505
更新日期：2020-04-03 00:00:00
abstract：:Winter's advent invokes physiological adjustments that permit temperate ectotherms to cope with stresses such as food shortage, water deprivation, hypoxia, and hypothermia. We used liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) quantitative isobaric (iTRAQ™) peptide mapping to assess v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128406
更新日期：2011-01-01 00:00:00
abstract：:Yeast proteins Ntr1, Ntr2 and Prp43 function in spliceosome disassembly. An Ntr1-Ntr2 protein complex recruits Prp43 to allow the removal of the lariat-intron in late-stage RNA splicing activity. Based on amino-acid sequence similarities across species, TFIP11 and mDEAH9/Dhx15 have been identified as homologues of yea...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9112105
更新日期：2008-11-01 00:00:00
abstract：:NAC (no apical meristem (NAM), Arabidopsis thaliana transcription activation factor (ATAF1/2) and cup shaped cotyledon (CUC2)) transcription factors play crucial roles in plant development and stress responses. Nevertheless, to date, only a few reports regarding stress-related NAC genes are available in Malus baccata(...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041198
更新日期：2020-02-11 00:00:00
abstract：:Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030268
更新日期：2016-02-23 00:00:00
abstract：:ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively. However, the specific receptor of ABA that triggers the positive and negative responses of ABA during immune resp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165852
更新日期：2020-08-14 00:00:00
abstract：:Dysregulation of platelet function can contribute to the disease progression in sepsis. The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. However, the role of the platelet proteasome as well as its...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235961
更新日期：2019-11-27 00:00:00
abstract：:Atherosclerosis is an arterial inflammatory disease. The circulating level of the C-C chemokine ligand (CCL4) is increased in atherosclerotic patients. This study aimed to investigate whether CCL4 inhibition could retard the progression of atherosclerosis. In ApoE knockout mice, CCL4 antibody treatment reduced circula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186567
更新日期：2020-09-08 00:00:00
abstract：:Parathyroid hormone-related protein (PTHrP), with isoforms ranging from 139 to 173 amino acids, has long been implicated in the development and regulation of multiple tissues, including that of the skeleton, via paracrine and autocrine signaling. PTHrP is also known as a potent mediator of cancer-induced bone disease,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112814
更新日期：2019-06-08 00:00:00
abstract：:Multiple myeloma (MM)-induced bone disease occurs through hyperactivation of osteoclasts by several factors secreted by MM cells. MM cell-secreted factors induce osteoclast differentiation and activation via direct and indirect actions including enhanced expression of receptor activator of nuclear factor κB ligand (RA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217905
更新日期：2020-10-24 00:00:00
abstract：:Sarcopenia is the degenerative loss of skeletal muscle mass and function associated with aging and occurs in the absence of any underlying disease or condition. A comparison of the age-related molecular signaling signatures of different muscles has not previously been reported. In this study, we compared the age-relat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082862
更新日期：2020-04-20 00:00:00
abstract：:Cystathionine β-synthase (CBS) domain containing proteins (CDCPs) constitute a big family in plants and some members in this family have been implicated in a variety of biological processes, but the precise functions and the underlying mechanism of the majority of this family in plant immunity remain to be elucidated....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160715903
更新日期：2015-07-13 00:00:00
abstract：:Phytochelatins (PCs) play an important role in detoxification of heavy metals in plants. PCs are synthesized from glutathione by phytochelatin synthase (PCS), a dipeptidyltransferase. Sesbania rostrata is a tropical legume plant that can tolerate high concentrations of Cd and Zn. In this study, the S. rostrata PCS gen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10083269
更新日期：2009-07-24 00:00:00
abstract：:Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030690
更新日期：2020-01-21 00:00:00
abstract：:Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs). Understanding central nervous system (CNS) pathophysiology in neuronopathic MPS II (nMPS II) has been hi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155188
更新日期：2020-07-22 00:00:00
abstract：:Adenosine triphosphate (ATP) is a primordial versatile autacoid that changes its role from an intracellular energy saver to a signaling molecule once released to the extracellular milieu. Extracellular ATP and its adenosine metabolite are the main activators of the P2 and P1 purinoceptor families, respectively. Mounti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145005
更新日期：2020-07-15 00:00:00
abstract：:The ubiquitous second messenger 3',5'-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030801
更新日期：2018-03-10 00:00:00
abstract：:Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an uncontrolled wound healing response to injury in which tissue is replaced by deposition of excess extracellular matrix, leading to fibrosis and loss of organ function. A plethora of genome-wide association studies, microa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228590
更新日期：2020-11-14 00:00:00
abstract：:Lipopolysaccharides (LPS) are major outer membrane components of Gram-negative bacteria and produce strong inflammatory responses in animals. Most antibiotics have shown little clinical anti-endotoxin activity while some antimicrobial peptides have proved to be effective in blocking LPS. Here, the anti-LPS activity of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020600
更新日期：2018-02-17 00:00:00
