Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction.

abstract：:Modern strategies in adipose tissue engineering (ATE) take advantage of the easy harvest, abundance and differentiation potential towards mesenchymal lineages of hADSCs. The controlled conversion of hADSCs to committed adipogenic precursors and further mature adipocytes formation is important for good long-term result...

journal_title：International journal of molecular sciences

authors： Galateanu B,Dinescu S,Cimpean A,Dinischiotu A,Costache M

更新日期：2012-11-27 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO NPs) have shown adverse health impact on the human male reproductive system, with evidence of inducing apoptosis. However, whether or not ZnO NPs could promote autophagy, and the possible role of autophagy in the progress of apoptosis, remain unclear. In the current study, in vitro and in...

journal_title：International journal of molecular sciences

authors： Shen J,Yang D,Zhou X,Wang Y,Tang S,Yin H,Wang J,Chen R,Chen J

更新日期：2019-08-19 00:00:00

abstract：:The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...

journal_title：International journal of molecular sciences

authors： Melo S,Figueiredo J,Fernandes MS,Gonçalves M,Morais-de-Sá E,Sanches JM,Seruca R

更新日期：2017-12-12 00:00:00

abstract：:The red color of apples (Malus domestica) is an attractive trait for consumers. The green skinned "Granny Smith" cultivar develops red pigmentation after bagging treatment. DNA methylation plays an important role in various developmental processes in plants. To explore the possible functions of DNA methylation in the ...

journal_title：International journal of molecular sciences

authors： Ma C,Liang B,Chang B,Liu L,Yan J,Yang Y,Zhao Z

更新日期：2018-10-12 00:00:00

abstract：:Lipopolysaccharides (LPS, endotoxin) are complex and indispensable components of the outer membrane of most Gram-negative bacteria. They represent stimuli for many biological effects with pathophysiological character. Recombinant therapeutic proteins that are manufactured using biotechnological processes are prone to ...

journal_title：International journal of molecular sciences

authors： Correa W,Brandenburg K,Zähringer U,Ravuri K,Khan T,von Wintzingerode F

更新日期：2017-12-16 00:00:00

abstract：:The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this in mind, we have studied three models of high cardiovascular risk: hypertension (HT) with and without metabolic syndrome, familial hypercholesterolemia (FH) and familial combined hy...

journal_title：International journal of molecular sciences

authors： Mansego ML,Redon J,Martinez-Hervas S,Real JT,Martinez F,Blesa S,Gonzalez-Albert V,Saez GT,Carmena R,Chaves FJ

更新日期：2011-01-01 00:00:00

abstract：:The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...

journal_title：International journal of molecular sciences

authors： Al-Horani RA,Kar S,Aliter KF

更新日期：2020-07-23 00:00:00

abstract：:Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact. A reduction ...

journal_title：International journal of molecular sciences

authors： Bosiacki M,Gąssowska-Dobrowolska M,Kojder K,Fabiańska M,Jeżewski D,Gutowska I,Lubkowska A

更新日期：2019-08-22 00:00:00

abstract：:Adenylyl cyclase (AC) is a key enzyme that synthesizes cyclic AMP (cAMP) at the onset of the signaling pathway to activate sperm motility. Here, we showed that both transmembrane AC (tmAC) and soluble AC (sAC) are distinctly involved in the regulation of sperm motility in the ascidian Ciona intestinalis. A tmAC inhibi...

journal_title：International journal of molecular sciences

authors： Shiba K,Inaba K

更新日期：2014-07-28 00:00:00

abstract：:Histamine is a well-known mediator of inflammation that is released from mast cells and basophils. To date, many studies using histamine receptor antagonists have shown that histamine acts through four types of receptors: H1, H2, H3, and H4. Thus, histamine plays more roles in various diseases than had been predicted....

journal_title：International journal of molecular sciences

authors： Hirasawa N

更新日期：2019-01-16 00:00:00

abstract：:Recent data show that cardiac hypertrophy contributes substantially to the overall heart failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy. Recent studies have reported that isosteviol inhibits myocardial ischemia-reperfusion injury in guinea pigs and H9c2 cells. This work investigat...

journal_title：International journal of molecular sciences

authors： Liu F,Su H,Liu B,Mei Y,Ke Q,Sun X,Tan W

更新日期：2020-01-20 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or...

journal_title：International journal of molecular sciences

authors： Chen HF,Chuang HC,Tan TH

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:There are eighteen species within the Penicillium genus section chrysogena, including the original penicillin producers Penicillium notatum (Fleming strain) and Penicillium chrysogenum NRRL 1951. Other wild type isolates of the Penicillium genus are relevant for the production of useful proteins and primary ...

journal_title：International journal of molecular sciences

authors： Martín JF

更新日期：2020-05-30 00:00:00

abstract：:Genomic selection (GS) is a strategy to predict the genetic merits of individuals using genome-wide markers. However, GS prediction accuracy is affected by many factors, including missing rate and minor allele frequency (MAF) of genotypic data, GS models, trait features, etc. In this study, we used one wheat populatio...

journal_title：International journal of molecular sciences

authors： Ali M,Zhang Y,Rasheed A,Wang J,Zhang L

更新日期：2020-02-17 00:00:00

abstract：:Stem cells for regenerative medicine purposes offer therapeutic benefits, but disadvantages are still ill defined. The benefit of stem cells may be attributed to their secretion of growth factors (GFs), cytokines (CKs), and extracellular vesicles (EVs), including exosomes. We present a novel cell-free stem cell-derive...

journal_title：International journal of molecular sciences

authors： Gupta A,Cady C,Fauser AM,Rodriguez HC,Mistovich RJ,Potty AGR,Maffulli N

更新日期：2020-12-09 00:00:00

abstract：:The development of in situ major histocompatibility complex (MHC) tetramer (IST) staining to detect antigen (Ag)-specific T cells in tissues has radically revolutionized our knowledge of the local cellular immune response to viral and bacterial infections, cancers, and autoimmunity. IST combined with immunohistochemis...

journal_title：International journal of molecular sciences

authors： Abdelaal HM,Cartwright EK,Skinner PJ

更新日期：2019-10-18 00:00:00

abstract：:In homology-directed repair, mediated knock-in single-stranded oligodeoxynucleotides (ssODNs) can be used as a homologous template and present high efficiency, but there is still a need to improve efficiency. Previous studies have mainly focused on controlling double-stranded break size, ssODN stability, and the DNA r...

journal_title：International journal of molecular sciences

authors： Han JP,Chang YJ,Song DW,Choi BS,Koo OJ,Yi SY,Park TS,Yeom SC

更新日期：2020-05-26 00:00:00

abstract：:Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by devastating alterations to the cardiac conduction system as well as the structure of the atria. AF can lead to decreased cardiac function, heart failure, and other complications. Long non-coding RNAs (lncRNAs) have been shown t...

journal_title：International journal of molecular sciences

authors： Bektik E,Cowan DB,Wang DZ

更新日期：2020-07-30 00:00:00

abstract：:Increasing evidence implicates mitochondrial dysfunction in the etiology of Parkinson's disease (PD). Mitochondrial DNA (mtDNA) mutations are considered a possible cause and this mechanism might be shared with the aging process and with other age-related neurodegenerative disorders such as Alzheimer's disease (AD). We...

journal_title：International journal of molecular sciences

authors： Zaia A,Maponi P,Zannotti M,Casoli T

更新日期：2020-03-04 00:00:00

abstract：:The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/P...

journal_title：International journal of molecular sciences

authors： Ames PRJ,Merashli M,Bucci T,Pastori D,Pignatelli P,Arcaro A,Gentile F

更新日期：2020-06-09 00:00:00

abstract：:Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbi...

journal_title：International journal of molecular sciences

authors： Wong CC,Kuo TF,Yang TL,Tsuang YH,Lin MF,Chang CH,Lin YH,Chan WP

更新日期：2017-08-07 00:00:00

abstract：:Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...

journal_title：International journal of molecular sciences

authors： Erber L,Franz P,Betat H,Prohaska S,Mörl M

更新日期：2020-01-10 00:00:00

abstract：:Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordi...

journal_title：International journal of molecular sciences

authors： Krasnovskaya O,Naumov A,Guk D,Gorelkin P,Erofeev A,Beloglazkina E,Majouga A

更新日期：2020-05-31 00:00:00

abstract：:Transcription factor binding sites (TFBSs) play an important role in gene expression regulation. Many computational methods for TFBS prediction need sufficient labeled data. However, many transcription factors (TFs) lack labeled data in cell types. We propose a novel method, referred to as DANN_TF, for TFBS prediction...

journal_title：International journal of molecular sciences

authors： Lan G,Zhou J,Xu R,Lu Q,Wang H

更新日期：2019-07-12 00:00:00

abstract：:The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...

journal_title：International journal of molecular sciences

authors： Spead O,Poulain FE

更新日期：2020-07-21 00:00:00

abstract：:Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expe...

journal_title：International journal of molecular sciences

authors： Russow G,Jahn D,Appelt J,Märdian S,Tsitsilonis S,Keller J

更新日期：2018-12-26 00:00:00

abstract：:DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+ primary breast cancer cells, but the expression and subcellular localization of DUSPs, especially DUSP6, in HER2-positive circulating tumor cells (CTCs) is unkno...

journal_title：International journal of molecular sciences

authors： Wu F,McCuaig RD,Sutton CR,Tan AHY,Jeelall Y,Bean EG,Dai J,Prasanna T,Batham J,Malik L,Yip D,Dahlstrom JE,Rao S

更新日期：2019-06-24 00:00:00

abstract：:Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1....

journal_title：International journal of molecular sciences

authors： Wang X,Cao P,Li Z,Wu D,Wang X,Liang G

更新日期：2014-09-04 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) is one of the mechanisms of apoptotic cell death. Inhibiting the apoptosis induced by ERS may be a novel therapeutic target in cardiovascular diseases. Icariin, a flavonoid isolated from Epimedium brevicornum Maxim, has been demonstrated to have cardiovascular protective effects, but...

journal_title：International journal of molecular sciences

authors： Zhang Q,Li H,Wang S,Liu M,Feng Y,Wang X

更新日期：2013-08-30 00:00:00

abstract：:Ex vivo gene therapy offers enormous potential for cell-based therapies, however, cumbersome in vitro cell culture conditions have limited its use in clinical practice. We have optimized an innovative strategy for the transient transfection of bone morphogenetic protein-2 (BMP-2) expressing plasmids in suspended human...

journal_title：International journal of molecular sciences

authors： Paidikondala M,Kadekar S,Varghese OP

更新日期：2018-12-23 00:00:00