当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Distinct roles of soluble and transmembrane adenylyl cyclases in the regulation of flagellar motility in Ciona sperm.

Distinct roles of soluble and transmembrane adenylyl cyclases in the regulation of flagellar motility in Ciona sperm.

Abstract：

:Adenylyl cyclase (AC) is a key enzyme that synthesizes cyclic AMP (cAMP) at the onset of the signaling pathway to activate sperm motility. Here, we showed that both transmembrane AC (tmAC) and soluble AC (sAC) are distinctly involved in the regulation of sperm motility in the ascidian Ciona intestinalis. A tmAC inhibitor blocked both cAMP synthesis and the activation of sperm motility induced by the egg factor sperm activating and attracting factor (SAAF), as well as those induced by theophylline, an inhibitor of phoshodiesterase. It also significantly inhibited cAMP-dependent phosphorylation of a set of proteins at motility activation. On the other hand, a sAC inhibitor does not affect on SAAF-induced transient increase of cAMP, motility activation or protein phosphorylation, but it reduced swimming velocity to half in theophylline-induced sperm. A sAC inhibitor KH-7 induced circular swimming trajectory with smaller diameter and significantly suppressed chemotaxis of sperm to SAAF. These results suggest that tmAC is involved in the basic mechanism for motility activation through cAMP-dependent protein phosphorylation, whereas sAC plays distinct roles in increase of flagellar beat frequency and in the Ca2+-dependent chemotactic movement of sperm.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Shiba K,Inaba K

doi

10.3390/ijms150813192

subject

Has Abstract

pub_date

2014-07-28 00:00:00

pages

13192-208

issue

8

issn

1422-0067

pii

ijms150813192

journal_volume

15

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • The Role of Selective Protein Degradation in the Regulation of Iron and Sulfur Homeostasis in Plants.

    abstract：:Plants are able to synthesize all essential metabolites from minerals, water, and light to complete their life cycle. This plasticity comes at a high energy cost, and therefore, plants need to tightly allocate resources in order to control their economy. Being sessile, plants can only adapt to fluctuating environmenta...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21082771

    authors： Wawrzyńska A,Sirko A

    更新日期：2020-04-16 00:00:00

  • Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation.

    abstract：:Platelet P2Y12 is an important adenosine diphosphate (ADP) receptor that is involved in agonist-induced platelet aggregation and is a valuable target for the development of anti-platelet drugs. Here we characterise the effects of thio analogues of uridine triphosphate (UTP) on ADP-induced platelet aggregation. Using h...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18020269

    authors： Gündüz D,Tanislav C,Sedding D,Parahuleva M,Santoso S,Troidl C,Hamm CW,Aslam M

    更新日期：2017-01-29 00:00:00

  • Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury.

    abstract：BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20153748

    authors： Yang L,Dong C,Tian L,Ji X,Yang L,Li L

    更新日期：2019-07-31 00:00:00

  • The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer.

    abstract：:The insulin-like growth factor 2 (IGF2) mRNA binding protein IMP2 (IGF2BP2) is an oncogenic protein known to be overexpressed in different tumor types. Pancreatic cancer is a very lethal cancer that requires early diagnosis and new treatment options. The aim of our study was to investigate the role of IMP2 in the init...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133204

    authors： Dahlem C,Barghash A,Puchas P,Haybaeck J,Kessler SM

    更新日期：2019-06-29 00:00:00

  • Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.

    abstract：BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010227

    authors： Cheng IY,Liu CC,Lin JH,Hsu TW,Hsu JW,Li AF,Ho WC,Hung SC,Hsu HS

    更新日期：2019-12-28 00:00:00

  • Inhibition of stromal PlGF suppresses the growth of prostate cancer xenografts.

    abstract：:The growth and vascularization of prostate cancer is dependent on interactions between cancer cells and supporting stromal cells. The primary stromal cell type found in prostate tumors is the carcinoma-associated fibroblast, which produces placental growth factor (PlGF). PlGF is a member of the vascular endothelial gr...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140917958

    authors： Zins K,Thomas A,Lucas T,Sioud M,Aharinejad S,Abraham D

    更新日期：2013-09-03 00:00:00

  • Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts.

    abstract：:Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mech...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113744

    authors： Szabó MR,Gáspár R,Pipicz M,Zsindely N,Diószegi P,Sárközy M,Bodai L,Csont T

    更新日期：2020-05-26 00:00:00

  • Neurotrophic effect of citrus auraptene: neuritogenic activity in PC12 cells.

    abstract：:The activation of extracellular signal-regulated kinases (ERK) leads to a number of cellular changes associated with the development of long-term memory. Using cultured cortical neurons, we previously showed that the n-hexane extract prepared from the peels of Citrus grandis (Kawachi bankan) induces the activation of ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13055338

    authors： Furukawa Y,Watanabe S,Okuyama S,Nakajima M

    更新日期：2012-01-01 00:00:00

  • Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening.

    abstract：:Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopep...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17122099

    authors： Qiao L,Li B,Chen Y,Li L,Chen X,Wang L,Lu F,Luo G,Li G,Zhang Y

    更新日期：2016-12-14 00:00:00

  • Modular Chimeric Antigen Receptor Systems for Universal CAR T Cell Retargeting.

    abstract：:The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular CAR T systems is accelerating, allowing for multiple antigen targetin...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21197222

    authors： Sutherland AR,Owens MN,Geyer CR

    更新日期：2020-09-30 00:00:00

  • An Animal Model for Assessing the Effects of Hydroxyurea Exposure Suggests That the Administration of This Agent to Pregnant Women and Young Infants May Not Be as Safe as We Thought.

    abstract：:The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19123986

    authors： Rodríguez-Vázquez L,Martí J

    更新日期：2018-12-11 00:00:00

  • Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells.

    abstract：:CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the motility of breast cancer cells. Alisma canaliculatum is a herb that has been used as a traditional medicine for thousands of years in Korea and China. Whether A. canaliculatum inhibits the motil...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19092607

    authors： Choi J,Ahn SS,Lim Y,Lee YH,Shin SY

    更新日期：2018-09-03 00:00:00

  • Mitochondrial Damage and Necroptosis in Aging Cochlea.

    abstract：:Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder and is presently untreatable. Previous studies using animal models have suggested mitochondrial damage and programmed cell death to be involved with ARHL. Thus, we further investigated the pathophysiologic role of mitochondria a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21072505

    authors： Lyu AR,Kim TH,Park SJ,Shin SA,Jeong SH,Yu Y,Huh YH,Je AR,Park MJ,Park YH

    更新日期：2020-04-03 00:00:00

  • Total phenolic contents and antioxidant capacities of herbal and tea infusions.

    abstract：:In order to supply new information on the antioxidant function of selected beverages for nutritionists and the general public, total phenolic contents of 51 kinds of herbal and tea infusions made in China were measured by the Folin-Ciocalteu method, and their antioxidant capacities were evaluated using ferric reducing...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12042112

    authors： Fu L,Xu BT,Gan RY,Zhang Y,Xu XR,Xia EQ,Li HB

    更新日期：2011-01-01 00:00:00

  • Behavior of Gingival Fibroblasts on Titanium Implant Surfaces in Combination with either Injectable-PRF or PRP.

    abstract：:Various strategies have been employed to speed tissue regeneration using bioactive molecules. Interestingly, platelet concentrates derived from a patient's own blood have been utilized as a regenerative strategy in recent years. In the present study, a novel liquid platelet formulation prepared without the use of anti...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18020331

    authors： Wang X,Zhang Y,Choukroun J,Ghanaati S,Miron RJ

    更新日期：2017-02-04 00:00:00

  • Clinical Response to Personalized Exercise Therapy in Heart Failure Patients with Reduced Ejection Fraction is Accompanied by Skeletal Muscle Histological Alterations.

    abstract：:Abstract: Heart failure (HF) is associated with skeletal muscle wasting and exercise intolerance. This study aimed to evaluate the exercise-induced clinical response and histological alterations. One hundred and forty-four HF patients were enrolled. The individual training program was determined as a workload at or cl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20215514

    authors： Lelyavina TA,Galenko VL,Ivanova OA,Komarova MY,Ignatieva EV,Bortsova MA,Yukina GY,Khromova NV,Sitnikova MY,Kostareva AA,Sergushichev A,Dmitrieva RI

    更新日期：2019-11-05 00:00:00

  • The Effect of TBB, as an Initiator, on the Biological Compatibility of PMMA/MMA Bone Cement.

    abstract：:Acrylic bone cement is widely used in orthopedic surgery for treating various conditions of the bone and joints. Bone cement consists of methyl methacrylate (MMA), polymethyl methacrylate (PMMA), and benzoyl peroxide (BPO), functioning as a liquid monomer, solid phase, and polymerization initiator, respectively. Howev...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21114016

    authors： Hamajima K,Ozawa R,Saruta J,Saita M,Kitajima H,Taleghani SR,Usami D,Goharian D,Uno M,Miyazawa K,Goto S,Tsukinoki K,Ogawa T

    更新日期：2020-06-04 00:00:00

  • Pulmonary Arterial Hypertension and Hereditary Haemorrhagic Telangiectasia.

    abstract：:Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterised by multisystemic vascular dysplasia. Heritable pulmonary arterial hypertension (HPAH) is a rare but severe complication of HHT. Both diseases can be the result of genetic mutations in ACVLR1 and ENG encoding for prote...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19103203

    authors： Vorselaars VMM,Hosman AE,Westermann CJJ,Snijder RJ,Mager JJ,Goumans MJ,Post MC

    更新日期：2018-10-17 00:00:00

  • Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.

    abstract：:G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G protein activation during neurological, cardiovascular, sensory and reproductive signaling. Common and unique features of interactions between...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17111930

    authors： Sato T,Kawasaki T,Mine S,Matsumura H

    更新日期：2016-11-18 00:00:00

  • A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues.

    abstract：:Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20153832

    authors： Sirajudeen S,Shah I,Al Menhali A

    更新日期：2019-08-05 00:00:00

  • Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier".

    abstract：:For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly, the two families of claudins and TAMPs-several other functions have been discovered, a striking one...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms21134612

    authors： Krug SM,Fromm M

    更新日期：2020-06-29 00:00:00

  • Reduced Diet-induced Thermogenesis in Apolipoprotein A-IV Deficient Mice.

    abstract：:In the presence of dietary lipids, both apolipoprotein A-IV (ApoA-IV) production and brown adipose tissue (BAT) thermogenesis are increased. The effect of dietary lipid-induced AproA-IV on BAT thermogenesis and energy expenditure remains unknown. In the present study, we hypothesized that ApoA-IV knockout (ApoA-IV-KO)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133176

    authors： Pence S,Zhu Q,Binne E,Liu M,Shi H,Lo CC

    更新日期：2019-06-28 00:00:00

  • Effects of Fe2+/Fe3+ Binding to Human Frataxin and Its D122Y Variant, as Revealed by Site-Directed Spin Labeling (SDSL) EPR Complemented by Fluorescence and Circular Dichroism Spectroscopies.

    abstract：:Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich's ataxia. Frataxin's actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the biosynthetic iron-su...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249619

    authors： Doni D,Passerini L,Audran G,Marque SRA,Schulz M,Santos J,Costantini P,Bortolus M,Carbonera D

    更新日期：2020-12-17 00:00:00

  • Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells.

    abstract：:Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a "natural cancer fighter", being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141223545

    authors： Shafie NH,Esa NM,Ithnin H,Saad N,Pandurangan AK

    更新日期：2013-12-02 00:00:00

  • Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives.

    abstract：:A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and (1)H nuclear magnetic resonance spectra. Cytotoxicity of t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13078071

    authors： Yarim M,Koksal M,Durmaz I,Atalay R

    更新日期：2012-01-01 00:00:00

  • Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related

    abstract：:Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the onco...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218222

    authors： Guadagni S,Farina AR,Cappabianca LA,Sebastiano M,Maccarone R,Zelli V,Clementi M,Chiominto A,Bruera G,Ricevuto E,Fiorentini G,Sarti D,Mackay AR

    更新日期：2020-11-03 00:00:00

  • Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model.

    abstract：:Secondary caries often occurs at the tooth-composite margins. This study developed a novel bioactive composite containing DMAHDM (dimethylaminohexadecyl methacrylate) and NACP (nanoparticles of amorphous calcium phosphate), inhibiting caries at the enamel restoration margins in an in vitro saliva-derived biofilm secon...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176369

    authors： Zhou W,Peng X,Zhou X,Bonavente A,Weir MD,Melo MAS,Imazato S,Oates TW,Cheng L,Xu HHK

    更新日期：2020-09-02 00:00:00

  • PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates.

    abstract：:Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prostate-specific membran...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19103251

    authors： Xu B,Zhou F,Yan MM,Cai DS,Guo WB,Yang YQ,Jia XH,Zhang WX,Li T,Ma T,Wang PL,Lei HM

    更新日期：2018-10-19 00:00:00

  • An Integrated Approach of Proteomics and Computational Genetic Modification Effectiveness Analysis to Uncover the Mechanisms of Flood Tolerance in Soybeans.

    abstract：:Flooding negatively affects the growth of soybeans. Recently, omic approaches have been used to study abiotic stress responses in plants. To explore flood-tolerant genes in soybeans, an integrated approach of proteomics and computational genetic modification effectiveness analysis was applied to the soybean (Glycine m...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051301

    authors： Wang X,Sakata K,Komatsu S

    更新日期：2018-04-26 00:00:00

  • The Role of Cell Adhesion Molecule 1 (CADM1) in Cutaneous Malignancies.

    abstract：:Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and h...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21249732

    authors： Sawada Y,Mashima E,Saito-Sasaki N,Nakamura M

    更新日期：2020-12-20 00:00:00