Abstract：
:Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many epidemiological studies have reported a higher incidence in men than women with a sex ratio of 1:4. Based on these observations, it has been proposed that the neurosteroids and especially the estrogens found in higher concentrations in women's brains could, in part, explain this difference. Estrogens can bind to nuclear or membrane receptors and potentially stimulate many different interconnected signaling pathways. The study of these receptors is even more complex since many isoforms are produced from each estrogen receptor encoding gene through alternative promoter usage or splicing, with each of them potentially having a specific role in the cell. The purpose of this review is to discuss recent data supporting the involvement of steroids during gliomagenesis and to focus on the potential neuroprotective role as well as the mechanisms of action of estrogens in gliomas.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hirtz A,Rech F,Dubois-Pot-Schneider H,Dumond Hdoi
10.3390/ijms21239114subject
Has Abstractpub_date
2020-11-30 00:00:00issue
23issn
1422-0067pii
ijms21239114journal_volume
21pub_type
杂志文章,评审abstract：:Mammalian respiratory complex I (CI) biogenesis requires both nuclear and mitochondria-encoded proteins and is mostly organized in respiratory supercomplexes. Among the CI proteins encoded by the mitochondrial DNA, NADH-ubiquinone oxidoreductase chain 1 (ND1) is a core subunit, evolutionary conserved from bacteria to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030764
更新日期：2018-03-07 00:00:00
abstract：:Forty mice were randomly divided into four groups on the basis of the diet to be fed as follows: 5% (low) fat diet (T1: LF); 20% (high) fat diet (T2: HF); 20% fat containing 1% conjugated linoleic acid (CLA) (T3: HFC); and 20% fat containing 1% CLA with 0.5% biopolymers (T4: HFCB). The high-fat with CLA diet groups (H...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14046848
更新日期：2013-03-26 00:00:00
abstract：:Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a plethora of cellular mechanisms involved in healthy and pathological states such as platelet aggregation, lymphocyte activation, and tissue inflammation. AA has been described to activate Ca2+ entry through the arachidonate-regu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093315
更新日期：2020-05-07 00:00:00
abstract：:Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leachin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207541
更新日期：2020-10-13 00:00:00
abstract：:The modulation of neuronal cell firing is mediated by the release of the neurotransmitter GABA (γ-aminobuytric acid), which binds to two major families of receptors. The ionotropic GABAA receptors (GABAARs) are composed of five distinct subunits that vary in expression by brain region and cell type. The action of GABA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124445
更新日期：2020-06-22 00:00:00
abstract：:The abnormal deposition of calcium within renal parenchyma, termed nephrocalcinosis, frequently occurs as a result of impaired renal calcium handling. It is closely associated with renal stone formation (nephrolithiasis) as elevated urinary calcium levels (hypercalciuria) are a key common pathological feature underlyi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21010369
更新日期：2020-01-06 00:00:00
abstract：:Two mesenchymal zinc transporters, ZIP7 and ZIP13, play critical roles in dermal development. ZIP7 and ZIP13 are the closest among the conserved mammalian zinc transporters. However, whether their functions are complementary remains a controversial issue. In the present study, we found that the expression of ZIP13, bu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163941
更新日期：2019-08-13 00:00:00
abstract：:The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19040999
更新日期：2018-03-27 00:00:00
abstract：:Oxidative stress and the resulting damage to DNA are inevitable consequence of endogenous physiological processes further amplified by cellular responses to environmental exposures. If left unrepaired, oxidative DNA lesions can block essential processes such as transcription and replication or can induce mutations. Em...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20020364
更新日期：2019-01-16 00:00:00
abstract：:The Eisenberg plot or hydrophobic moment plot methodology is one of the most frequently used methods of bioinformatics. Bioinformatics is more and more recognized as a helpful tool in Life Sciences in general, and recent developments in approaches recognizing lipid binding regions in proteins are promising in this res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12095577
更新日期：2011-01-01 00:00:00
abstract：:Recent evidence suggests that C-X-C chemokine receptor type 4 (CXCR4) heteromerizes with α1A/B-adrenoceptors (AR) and atypical chemokine receptor 3 (ACKR3) and that CXCR4:α1A/B-AR heteromers are important for α₁-AR function in vascular smooth muscle cells (VSMC). Structural determinants for CXCR4 heteromerization and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060971
更新日期：2016-06-20 00:00:00
abstract：:Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replicat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020295
更新日期：2017-01-29 00:00:00
abstract：BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249765
更新日期：2020-12-21 00:00:00
abstract：:Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms150712196
更新日期：2014-07-09 00:00:00
abstract：:Among classical BCR-ABL-negative myeloproliferative neoplasms (MPN), primary myelofibrosis (PMF) is the most aggressive subtype from a clinical standpoint, posing a great challenge to clinicians. Whilst the biological consequences of the three MPN driver gene mutations (JAK2, CALR, and MPL) have been well described, r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21238885
更新日期：2020-11-24 00:00:00
abstract：:: The highly conserved transcription factor Pax6 is involved in the development of the eyes, brain, and pancreas in vertebrates and invertebrates, whereas the additional expression pattern in other organs is still elusive. In this study, we cloned and characterized two pax6 homologs in blunt snout bream (Megalobrama a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071710
更新日期：2019-04-05 00:00:00
abstract：:Melanogenesis is a biological process resulting in the production of melanin pigment, which plays an important role in the prevention of sun-induced skin injury, and determines hair and skin color. So, a wide variety of approaches have been proposed to increase the synthesis of melanin. This study evaluated the effect...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103211
更新日期：2018-10-17 00:00:00
abstract：:Oligoribonucleotide (ORN) interference-PCR (ORNi-PCR) is a method in which PCR amplification of a target sequence is inhibited in a sequence-specific manner by the hybridization of an ORN with the target sequence. Previously, we reported that ORNi-PCR could detect nucleotide mutations in DNA purified from cultured can...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145119
更新日期：2020-07-20 00:00:00
abstract：:Autophagy primarily works to counteract nutrient deprivation that is strongly engaged during starvation and hypoxia, which happens in hypoperfusion. Nonetheless, autophagy is slightly active even in baseline conditions, when it is useful to remove aged proteins and organelles. This is critical when the mitochondria an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092756
更新日期：2018-09-13 00:00:00
abstract：:Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be cons...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18061183
更新日期：2017-06-02 00:00:00
abstract：:Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246172
更新日期：2019-12-06 00:00:00
abstract：:The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications. Here we show, that a multi-target ligand of aminergic G protein-coupled receptors with antipsychotic activity in vivo (D2AAK1) stimulates neuron growth and surviv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228849
更新日期：2020-11-23 00:00:00
abstract：:The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160510324
更新日期：2015-05-06 00:00:00
abstract：:X-ray diffraction and tension measurement experiments were conducted on rat left ventricular skinned fibers with or without "troponin-T treatment," which exchanges the endogenous troponin T/I/C complex with exogenous troponin-T. These experiments were performed to observe the structural changes in troponin-T within a ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103520
更新日期：2020-05-15 00:00:00
abstract：:Antibacterial peptides (APMs) are a new type of antibacterial substance. The relationship between their structure and function remains indistinct; in particular, there is a lack of a definitive and fixed template for designing new antimicrobial peptides. Previous studies have shown that porcine Protegrin-1 (PG-1) exhi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163954
更新日期：2019-08-14 00:00:00
abstract：:The mitochondrial response to changes of cytosolic calcium concentration has a strong impact on neuronal cell metabolism and viability. We observed that Ca(2+) additions to isolated rat brain mitochondria induced in potassium ion containing media a mitochondrial membrane potential depolarization and an accompanying in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10031104
更新日期：2009-03-01 00:00:00
abstract：:Acoustic wave biosensors are a real-time, label-free biosensor technology, which have been exploited for the detection of proteins and cells. One of the conventional biosensor approaches involves the immobilization of a monolayer of antibodies onto the surface of the acoustic wave device for the detection of a specifi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9020154
更新日期：2008-02-01 00:00:00
abstract：:The introduction of glyphosate-resistant (GR) crops revolutionized weed management; however, the improper use of this technology has selected for a wide range of weeds resistant to glyphosate, referred to as superweeds. We characterized the high glyphosate resistance level of an Amaranthus hybridus population (GRH)-a ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102396
更新日期：2019-05-15 00:00:00
abstract：:The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular activities and survival. Disturbances in the normal ER functions lead to the accumulation and aggregation of unfolded proteins, which initiates an adaptive response, the unfolded protein response (UPR), in order to regain normal ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17091558
更新日期：2016-09-15 00:00:00
abstract：:High-density polyethylene (PE) foils were modified by an Ar(+) plasma discharge and subsequent grafting with biomolecules, namely glycine (Gly), polyethylene glycol (PEG), bovine serum albumin (BSA), colloidal carbon particles (C) or BSA and C (BSA + C). As revealed by atomic force microscopy (AFM), goniometry and Rut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10104352
更新日期：2009-11-20 00:00:00
