Abstract：
:Oxidative stress and the resulting damage to DNA are inevitable consequence of endogenous physiological processes further amplified by cellular responses to environmental exposures. If left unrepaired, oxidative DNA lesions can block essential processes such as transcription and replication or can induce mutations. Emerging data also indicate that oxidative base modifications such as 8-oxoG in gene promoters may serve as epigenetic marks, and/or provide a platform for coordination of the initial steps of DNA repair and the assembly of the transcriptional machinery to launch adequate gene expression alterations. Here, we briefly review the current understanding of oxidative lesions in genome stability maintenance and regulation of basal and inducible transcription.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bokhari B,Sharma Sdoi
10.3390/ijms20020364subject
Has Abstractpub_date
2019-01-16 00:00:00issue
2issn
1422-0067pii
ijms20020364journal_volume
20pub_type
杂志文章,评审abstract：:For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092537
更新日期：2018-08-27 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has emerged as an important player in asthma control. AhR is responsive to environmental molecules and endogenous or dietary metabolites and regulates innate and adaptive immune responses. Binding of this receptor by different ligands ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-11-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-10-09 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-09-12 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-09-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-05-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194743
更新日期：2019-09-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11072681
更新日期：2010-07-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17101700
更新日期：2016-10-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14010226
更新日期：2012-12-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122652
更新日期：2017-12-07 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-07-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-10-18 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20092175
更新日期：2019-05-02 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-11-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-05-09 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2009-03-01 00:00:00
abstract：:The aim of the study was to verify if quantification of placental specific C19MC microRNAs in plasma exosomes would be able to differentiate during the early stages of gestation between patients subsequently developing pregnancy-related complications and women with the normal course of gestation and if this differenti...
journal_title：International journal of molecular sciences
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更新日期：2019-06-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-05-21 00:00:00
abstract：:In this review, the latest research concerning the structure and function of the 5'-terminal region of p53 mRNA was discussed. Special attention was focused on defined structural motifs which are present in this region, as well as their conservation and plausible functional role in translation. It is known that the le...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-10-29 00:00:00
abstract：:Due to the present scenario of climate change, plants have to evolve strategies to survive and perform under a plethora of biotic and abiotic stresses, which restrict plant productivity. Maintenance of plant protein functional conformation and preventing non-native proteins from aggregation, which leads to metabolic d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20215321
更新日期：2019-10-25 00:00:00
abstract：:The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102229
更新日期：2017-10-24 00:00:00
