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MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line.

Abstract：

:MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Ma D,Jia H,Qin M,Dai W,Wang T,Liang E,Dong G,Wang Z,Zhang Z,Feng F

doi

10.3390/ijms160922137

subject

Has Abstract

pub_date

2015-09-14 00:00:00

pages

22137-50

issue

9

issn

1422-0067

pii

ijms160922137

journal_volume

16

pub_type

杂志文章

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