Abstract：
:Neurodegenerative proteinopathies are complex diseases that share some pathogenetic processes. One of these is the failure of the proteostasis network (PN), which includes all components involved in the synthesis, folding, and degradation of proteins, thus leading to the aberrant accumulation of toxic protein aggregates in neurons. The single components that belong to the three main modules of the PN are highly interconnected and can be considered as part of a single giant network. Several pharmacological strategies have been proposed to ameliorate neurodegeneration by targeting PN components. Nevertheless, effective disease-modifying therapies are still lacking. In this review article, after a general description of the PN and its failure in proteinopathies, we will focus on the available pharmacological tools to target proteostasis. In this context, we will discuss the main advantages of systems-based pharmacology in contrast to the classical targeted approach, by focusing on network pharmacology as a strategy to innovate rational drug design.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lualdi M,Alberio T,Fasano Mdoi
10.3390/ijms21176405subject
Has Abstractpub_date
2020-09-03 00:00:00issue
17issn
1422-0067pii
ijms21176405journal_volume
21pub_type
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