Abstract：
:Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kravtsov DV,Ameen NAdoi
10.3390/ijms14059628subject
Has Abstractpub_date
2013-05-03 00:00:00pages
9628-42issue
5issn
1422-0067pii
ijms14059628journal_volume
14pub_type
杂志文章,评审abstract：:Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear. Here, we derived e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165743
更新日期：2020-08-11 00:00:00
abstract：:Oil palm is an oil-producing crop of major importance at the global scale. Oil palm mesocarp lipids are used for myriads industrial applications, and market demand has been growing for decades. In addition, oil palm seeds are oleaginous, and the oil extracted therefrom can be used for several purposes, from food to co...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124227
更新日期：2020-06-13 00:00:00
abstract：:Chronic kidney disease (CKD) is associated with atherogenic dyslipidemia. Our aim was firstly to investigate patterns of fatty acids (FA) composition through various stages of CKD, and secondly, to evaluate the effect of CKD-specific FA disturbances on the expression of genes related to lipid metabolism at a cellular ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102470
更新日期：2019-05-18 00:00:00
abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) gene encodes for p35, the main activator of Cyclin-dependent kinase 5 (CDK5). The active p35/CDK5 complex is involved in numerous aspects of brain development and function, and its deregulation is closely associated to Alzheimer's disease (AD) onset and progressi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072022
更新日期：2018-07-11 00:00:00
abstract：:Histone deacetylases (HDACs) play a significant role in a plant's development and response to various environmental stimuli by regulating the gene transcription. However, HDACs remain unidentified in cotton. In this study, a total of 29 HDACs were identified in allotetraploid Gossypium hirsutum, while 15 and 13 HDACs ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010321
更新日期：2020-01-03 00:00:00
abstract：:A new chemical pathway yielding A-type vitisins in red wines is proposed herein from the reaction between anthocyanins and oxaloacetic acid (OAA). This new chemical path is thought to occur in the first stages of the wine production even during the fermentation process. This is due to the revealed high reactivity of O...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040762
更新日期：2017-04-04 00:00:00
abstract：:Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce molecular and cellular effects linked to adverse health outcomes, such as liver tumor promotion or chronic liver diseases. The alternation of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-08-23 00:00:00
abstract：:Citrus fruit are sensitive to chilling injury (CI) during cold storage, a peel disorder that causes economic losses. C-repeat binding factors (CBFs) are related to cold acclimation and tolerance in different plants. To explore the role of Citrus CBFs in fruit response to cold, an in silico study was performed, reveali...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020804
更新日期：2021-01-15 00:00:00
abstract：:Immune response plays a fundamental role in protecting the organism from infections; however, dysregulation often occurs and can be detrimental for the organism, leading to a variety of immune-mediated diseases. Recently our understanding of the molecular and cellular networks regulating the immune response, and, in p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140917347
更新日期：2013-08-22 00:00:00
abstract：:The purpose of the study was to investigate the antioxidant characteristics of Anisomeles indica methanol extract and the inhibitory effect of ovatodiolide on melanogenesis. In the study, the antioxidant capacities of A. indica methanol extract such as DPPH assay, ABTS radical scavenging assay, reducing capacity and m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056220
更新日期：2012-01-01 00:00:00
abstract：:Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071125
更新日期：2016-07-14 00:00:00
abstract：:Hexavalent chromium (Cr(VI)) is a serious environmental pollutant and human toxicant. Mammalian cells are very sensitive to chromate as they lack efficient chromate detoxifying strategy, e.g., chromate-reducing genes that are widely present in prokaryotes. To test whether introduction of prokaryotic chromate-reducing ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160611892
更新日期：2015-05-26 00:00:00
abstract：:Mast cells (MCs) are inflammatory cells primarily found in tissues in close contact with the external environment, such as the skin and the intestinal mucosa. They store large amounts of active components in cytoplasmic granules, ready for rapid release. The major protein content of these granules is proteases, which ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010319
更新日期：2020-01-02 00:00:00
abstract：:The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197267
更新日期：2020-10-01 00:00:00
abstract：:The renal cortex drives renal function. Hypoxia/reoxygenation are primary factors in ischemia-reperfusion (IR) injuries, but renal oxygenation per se is complex and awaits full elucidation. Few mathematical models address this issue: none captures cortical tissue heterogeneity. Using agent-based modeling, we develop t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246246
更新日期：2019-12-11 00:00:00
abstract：:The activating leukocyte immunoglobulin-like receptors (LILRAs) play an important role in innate immunity. However, most of the LILRA members have not been characterized in avian species including chickens. The present study is the first attempt at cloning, structural analysis and functional characterization of two LI...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092710
更新日期：2018-09-11 00:00:00
abstract：:Dietary NaCl depletion increases Na+ and Cl- absorption in the colon, but the mechanisms are not fully understood. So far, we reported that the expression of claudin-7 (CLDN7), a tight junction (TJ) protein, was upregulated in the mice fed with NaCl-depleted diets, but the regulatory mechanism has not been clarified. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041442
更新日期：2020-02-20 00:00:00
abstract：:It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia. Balb/c mice were randomly divided into groups of chemical pretr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610999
更新日期：2014-06-18 00:00:00
abstract：:Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...
journal_title：International journal of molecular sciences
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更新日期：2020-07-01 00:00:00
abstract：:As an angiogenesis inhibitor, bevacizumab has been investigated in combination with different chemotherapeutic agents, achieving an established role for metastatic cancer treatment. However, potential synergic anti-angiogenic effects of hyperthermia have not tested to date in literature. The aim of our study was to an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071458
更新日期：2017-07-06 00:00:00
abstract：:Pyrroloquinoline quinone (PQQ) is a novel stimulator of mitochondrial biogenesis and cellular energy metabolism. This is the first study investigating regulatory mechanisms and metabolic responses underlying PQQ's action in palmitate-exposed L6 myotubes. Particularly, we assessed alterations in lipid content and compo...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms21218382
更新日期：2020-11-08 00:00:00
abstract：:The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, which are involved in mRNA translation. It is activated by diverse sti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms13021886
更新日期：2012-01-01 00:00:00
abstract：:Electrospun fibrous substrates mimicking extracellular matrices can be prepared by electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial nerves. Gelatin aligned nano-fibers were prepared by electrospinning after tuning the collector rotation speed. The effect of alignment on ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160612925
更新日期：2015-06-08 00:00:00
abstract：:Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observation...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072466
更新日期：2020-04-02 00:00:00
abstract：:Hibiscus aridicola (Malvaceae) is an endangered ornamental shrub endemic to the dry-hot valleys of Jinsha River in southwest China. Only four natural populations of H. aridicola exist in the wild according to our field investigation. It can be inferred that H. aridicola is facing a very high risk of extinction in the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12095698
更新日期：2011-01-01 00:00:00
abstract：:Oligoribonucleotide (ORN) interference-PCR (ORNi-PCR) is a method in which PCR amplification of a target sequence is inhibited in a sequence-specific manner by the hybridization of an ORN with the target sequence. Previously, we reported that ORNi-PCR could detect nucleotide mutations in DNA purified from cultured can...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms21145119
更新日期：2020-07-20 00:00:00
abstract：:Plant architecture is critical for enhancing the adaptability and productivity of crop plants. Mutants with an altered plant architecture allow researchers to elucidate the genetic network and the underlying mechanisms. In this study, we characterized a novel nal1 rice mutant with short height, small panicle, and narr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218106
更新日期：2020-10-30 00:00:00
abstract：:Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate comple...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071185
更新日期：2016-07-21 00:00:00
abstract：:The objective of this article was to document the energy-transducing and regulatory interactions in supramolecular complexes such as motor, pump, and clock ATPases. The dynamics and structural features were characterized by motion and distance measurements using spin-labeling electron paramagnetic resonance (EPR) spec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020672
更新日期：2020-01-20 00:00:00
abstract：:Civilization diseases associated with memory disorders are important health problems occurring due to a prolonged life span. The manuscript shows the results of an in vivo study targeting the emergence of two drug candidates with anti-amnestic properties. The preceding quantitative structure-activity relationship (QSA...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms18122511
更新日期：2017-11-24 00:00:00
