当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation.

Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation.

Abstract：

:Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located in the ependymal canal (epSPC). epSPC from non-injured animals showed high expression levels of Cx50 compared to epSPC from animals with spinal cord injury (SCI) (epSPCi). When epSPC or epSPCi were induced to spontaneously differentiate in vitro we found that Cx50 favors glial cell fate, since higher expression levels, endogenous or by over-expression of Cx50, augmented the expression of the astrocyte marker GFAP and impaired the neuronal marker Tuj1. Cx50 was found in both the cytoplasm and nucleus of glial cells, astrocytes and oligodendrocyte-derived cells. Similar expression patterns were found in primary cultures of mature astrocytes. In addition, opposite expression profile for nuclear Cx50 was observed when epSPC and activated epSPCi were conducted to differentiate into mature oligodendrocytes, suggesting a different role for this ion channel in spinal cord beyond cell-to-cell communication. In vivo detection of Cx50 by immunohistochemistry showed a defined location in gray matter in non-injured tissues and at the epicenter of the injury after SCI. epSPCi transplantation, which accelerates locomotion regeneration by a neuroprotective effect after acute SCI is associated with a lower signal of Cx50 within the injured area, suggesting a minor or detrimental contribution of this ion channel in spinal cord regeneration by activated epSPCi.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Rodriguez-Jimenez FJ,Alastrue-Agudo A,Stojkovic M,Erceg S,Moreno-Manzano V

doi

10.3390/ijms161125981

subject

Has Abstract

pub_date

2015-11-06 00:00:00

pages

26608-18

issue

11

issn

1422-0067

pii

ijms161125981

journal_volume

16

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone.

    abstract：:Notwithstanding the widespread use and promising clinical value of chemotherapy, the pharmacokinetics, toxicology, and mechanism of mitoxantrone remains unclear. To promote the clinical value in the treatment of human diseases and the exploration of potential subtle effects of mitoxantrone, zebrafish embryos were empl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19113516

    authors： Liu L,Zhu H,Yan Y,Lv P,Wu W

    更新日期：2018-11-08 00:00:00

  • Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis.

    abstract：:Chorea acanthocytosis (ChAc), an ultra-rare devastating neurodegenerative disease, is caused by mutations in the VPS13A gene, which encodes for the protein chorein. Affected patients suffer from chorea, orofacial dyskinesia, epilepsy, parkinsonism as well as peripheral neuropathy. Although medium spinal neurons of the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051797

    authors： Glaß H,Neumann P,Pal A,Reinhardt P,Storch A,Sterneckert J,Hermann A

    更新日期：2020-03-05 00:00:00

  • The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes.

    abstract：:Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation of volume-sensitive Cl- current (ICl,vol) mediates cell shrinkage, triggering apoptosis in rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is frequently used for the tr...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141019705

    authors： Kumagai K,Kubo M,Imai S,Toyoda F,Maeda T,Okumura N,Matsuura H,Matsusue Y

    更新日期：2013-09-30 00:00:00

  • The Implication of Substance P in the Development of Tendinopathy: A Case Control Study.

    abstract：:It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and ten...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061241

    authors： Han SH,Choi W,Song J,Kim J,Lee S,Choi Y,Byun SE,Ahn T,Ahn H,Ding C,Baik L,Ward S,Ting K,Lee S

    更新日期：2017-06-09 00:00:00

  • High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy.

    abstract：:The adaptation of adenoviruses as gene delivery tools has resulted in the development of high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or "gutless". Compared with earlier generations (E1/E3-deleted vectors), HC-AdVs retain relevant features such as genetic stability, remarkable efficacy of i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21103643

    authors： Ricobaraza A,Gonzalez-Aparicio M,Mora-Jimenez L,Lumbreras S,Hernandez-Alcoceba R

    更新日期：2020-05-21 00:00:00

  • Recognizing Depression from the Microbiota⁻Gut⁻Brain Axis.

    abstract：:Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain⁻gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherap...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19061592

    authors： Liang S,Wu X,Hu X,Wang T,Jin F

    更新日期：2018-05-29 00:00:00

  • Empowering Shotgun Mass Spectrometry with 2DE: A HepG2 Study.

    abstract：:One of the major goals of the Chromosome-Centric Human Proteome Project (C-HPP) is to catalog and annotate a myriad of heterogeneous proteoforms, produced by ca. 20 thousand genes. To achieve a detailed and personalized understanding into proteomes, we suggest using a customized RNA-seq library of potential proteoform...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113813

    authors： Kiseleva O,Ponomarenko E,Poverennaya E

    更新日期：2020-05-27 00:00:00

  • Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma.

    abstract：:Glioblastoma (GBM) is considered one of the most malignant, genetically heterogeneous, and therapy-resistant solid tumor. Therapeutic options are limited in GBM and involve surgical resection followed by chemotherapy and/or radiotherapy. Adjuvant therapies, including antiangiogenic treatments (AATs) targeting the VEGF...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18122732

    authors： Arbab AS,Rashid MH,Angara K,Borin TF,Lin PC,Jain M,Achyut BR

    更新日期：2017-12-16 00:00:00

  • Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine.

    abstract：:Many nutrients are absorbed via Na+ cotransport systems, and therefore it is predicted that nutrient absorption mechanisms require a large amount of luminal Na+. It is thought that Na+ diffuses back into the lumen via paracellular pathways to support Na+ cotransport absorption. However, direct experimental evidence in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020376

    authors： Nakayama M,Ishizuka N,Hempstock W,Ikari A,Hayashi H

    更新日期：2020-01-07 00:00:00

  • Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice.

    abstract：:Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and South...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18102177

    authors： Li W,Yang J,Cai J,Wang H,Tian H,Huang J,Qiang W,Zhang L,Li H,Li X,Jiang C

    更新日期：2017-10-18 00:00:00

  • Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species.

    abstract：:Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010032

    authors： Karnaneedi S,Huerlimann R,Johnston EB,Nugraha R,Ruethers T,Taki AC,Kamath SD,Wade NM,Jerry DR,Lopata AL

    更新日期：2020-12-22 00:00:00

  • Regulation of Gene Expression of Methionine Sulfoxide Reductases and Their New Putative Roles in Plants.

    abstract：:Oxidation of methionine to methionine sulfoxide is a type of posttranslational modification reversed by methionine sulfoxide reductases (Msrs), which present an exceptionally high number of gene copies in plants. The side-form general antioxidant function-specific role of each Msr isoform has not been fully studied. T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20061309

    authors： Kalemba EM,Stolarska E

    更新日期：2019-03-15 00:00:00

  • Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes.

    abstract：:To investigate whether ocular albinism type 1 (OA1) is differentially expressed in the skin of mice with different coat colors and to determine its correlation with coat color establishment in mouse, the expression patterns and tissue distribution characterization of OA1 in the skin of mice with different coat colors ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17101596

    authors： Chen T,Wang H,Liu Y,Zhao B,Zhao Y,Fan R,Wang P,Dong C

    更新日期：2016-09-27 00:00:00

  • A specific oligodeoxynucleotide promotes the differentiation of osteoblasts via ERK and p38 MAPK pathways.

    abstract：:A specific oligodeoxynucleotide (ODN), ODN MT01, was found to have positive effects on the proliferation and activation of the osteoblast-like cell line MG 63. In this study, the detailed signaling pathways in which ODN MT01 promoted the differentiation of osteoblasts were systematically examined. ODN MT01 enhanced th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13077902

    authors： Hou X,Shen Y,Zhang C,Zhang L,Qin Y,Yu Y,Wang L,Sun X

    更新日期：2012-01-01 00:00:00

  • Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels.

    abstract：:Hyperpolarization-activated cationic HCN channels comprise four members (HCN1-4) that control dendritic integration, synaptic transmission and action potential firing. In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephron...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20204995

    authors： León-Aparicio D,Salvador C,Aparicio-Trejo OE,Briones-Herrera A,Pedraza-Chaverri J,Vaca L,Sampieri A,Padilla-Flores T,López-González Z,León-Contreras JC,Hernández-Pando R,Escobar LI

    更新日期：2019-10-09 00:00:00

  • The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation.

    abstract：:Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. In wild-t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092211

    authors： Moreno P,Cazuza RA,Mendes-Gomes J,Díaz AF,Polo S,Leánez S,Leite-Panissi CRA,Pol O

    更新日期：2019-05-05 00:00:00

  • Experimental Model Systems for Understanding Human Axonal Injury Responses.

    abstract：:Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To unders...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22020474

    authors： Lee B,Cho Y

    更新日期：2021-01-06 00:00:00

  • Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres.

    abstract：:Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Sil...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113745

    authors： Honda M,Kawanobe Y,Nagata K,Ishii K,Matsumoto M,Aizawa M

    更新日期：2020-05-26 00:00:00

  • Molecular Insight into the Anti-Inflammatory Effects of the Curcumin Ester Prodrug Curcumin Diglutaric Acid In Vitro and In Vivo.

    abstract：:Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be developed as an anti-inflammatory agent due to its improved solubility and stability. In this study, the anti-inflammatory effects of CurDG were evaluated. The effects of CurDG on inflammatory mediators were evaluated in LPS-stimul...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165700

    authors： Phumsuay R,Muangnoi C,Dasuni Wasana PW,Hasriadi,Vajragupta O,Rojsitthisak P,Towiwat P

    更新日期：2020-08-09 00:00:00

  • Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study).

    abstract：:The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into fou...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155336

    authors： Mandel IA,Podoksenov YK,Suhodolo IV,An DA,Mikheev SL,Podoksenov AY,Svirko YS,Gusakova AM,Shipulin VM,Yavorovskiy AG

    更新日期：2020-07-27 00:00:00

  • Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver.

    abstract：:Few studies have been conducted regarding the biological function and regulation role of gga-miR-221-5p in the liver. We compared the conservation of miR-221-5p among species and investigated the expression pattern of gga-miR-221-5p, validating the direct target genes of gga-miR-221-5p by dual luciferase reporter assa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051624

    authors： Zhang DD,Wang DD,Wang Z,Wang YB,Li GX,Sun GR,Tian YD,Han RL,Li ZJ,Jiang RR,Liu XJ,Kang XT,Li H

    更新日期：2020-02-27 00:00:00

  • Investigations on the mechanical properties of conducting polymer coating-substrate structures and their influencing factors.

    abstract：:This review covers recent advances and work on the microstructure features, mechanical properties and cracking processes of conducting polymer film/coating- substrate structures under different testing conditions. An attempt is made to characterize and quantify the relationships between mechanical properties and micro...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms10125257

    authors： Wang XS,Tang HP,Li XD,Hua X

    更新日期：2009-12-08 00:00:00

  • Circulating Cell-Free Tumour DNA in the Management of Cancer.

    abstract：:With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these "liquid bio...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms160614122

    authors： Francis G,Stein S

    更新日期：2015-06-19 00:00:00

  • The Hedgehog Signaling Pathway in Ischemic Tissues.

    abstract：:Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20215270

    authors： Giarretta I,Gaetani E,Bigossi M,Tondi P,Asahara T,Pola R

    更新日期：2019-10-24 00:00:00

  • Vaccinations for Colorectal Cancer: Progress, Strategies, and Novel Adjuvants.

    abstract：:Although cancer is a leading cause of death, significant breakthroughs have been made in its treatment in recent years. In particular, increasingly effective cancer vaccines are being developed, including some for colorectal cancer. There are also currently a variety of compounds that can act as adjuvants, such as sig...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20143403

    authors： Jiang S,Good D,Wei MQ

    更新日期：2019-07-11 00:00:00

  • Zinc as a Signal to Stimulate Red Blood Cell Formation in Fish.

    abstract：:The common carp can tolerate extremely low oxygen levels. These fish store zinc in a specific zinc-binding protein presented in digestive tract tissues, and under low oxygen, the stored zinc is released and used as a signal to stimulate erythropoiesis (red blood cell formation). To determine whether the environmental ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18010138

    authors： Chen YH,Shiu JR,Ho CL,Jeng SS

    更新日期：2017-01-11 00:00:00

  • Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.

    abstract：:Niemann-Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010452

    authors： Fukaura M,Ishitsuka Y,Shirakawa S,Ushihama N,Yamada Y,Kondo Y,Takeo T,Nakagata N,Motoyama K,Higashi T,Arima H,Kurauchi Y,Seki T,Katsuki H,Higaki K,Matsuo M,Irie T

    更新日期：2021-01-05 00:00:00

  • Behavioral Abnormality Induced by Enhanced Hypothalamo-Pituitary-Adrenocortical Axis Activity under Dietary Zinc Deficiency and Its Usefulness as a Model.

    abstract：:Dietary zinc deficiency increases glucocorticoid secretion from the adrenal cortex via enhanced hypothalamo-pituitary-adrenocortical (HPA) axis activity and induces neuropsychological symptoms, i.e., behavioral abnormality. Behavioral abnormality is due to the increase in glucocorticoid secretion rather than disturban...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17071149

    authors： Takeda A,Tamano H,Nishio R,Murakami T

    更新日期：2016-07-16 00:00:00

  • Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.

    abstract：:The critical initial steps in insulin action include phosphorylation of adapter proteins and activation of phosphatidylinositol 3-kinase (PI3K). One of important components in this process is a protein called Akt/protein kinase B (PKB). The work of numerous different researchers indicates a role of PKB in regulating i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms9112217

    authors： Cho JY,Park J

    更新日期：2008-11-01 00:00:00

  • We Are What We Eat: A Stoichiometric and Ecometabolomic Study of Caterpillars Feeding on Two Pine Subspecies of Pinus sylvestris.

    abstract：:Many studies have addressed several plant-insect interaction topics at nutritional, molecular, physiological, and evolutionary levels. However, it is still unknown how flexible the metabolism and the nutritional content of specialist insect herbivores feeding on different closely related plants can be. We performed el...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20010059

    authors： Rivas-Ubach A,Peñuelas J,Hódar JA,Oravec M,Paša-Tolić L,Urban O,Sardans J

    更新日期：2018-12-24 00:00:00