当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy.

High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy.

Abstract：

:The adaptation of adenoviruses as gene delivery tools has resulted in the development of high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or "gutless". Compared with earlier generations (E1/E3-deleted vectors), HC-AdVs retain relevant features such as genetic stability, remarkable efficacy of in vivo transduction, and production at high titers. More importantly, the lack of viral coding sequences in the genomes of HC-AdVs extends the cloning capacity up to 37 Kb, and allows long-term episomal persistence of transgenes in non-dividing cells. These properties open a wide repertoire of therapeutic opportunities in the fields of gene supplementation and gene correction, which have been explored at the preclinical level over the past two decades. During this time, production methods have been optimized to obtain the yield, purity, and reliability required for clinical implementation. Better understanding of inflammatory responses and the implementation of methods to control them have increased the safety of these vectors. We will review the most significant achievements that are turning an interesting research tool into a sound vector platform, which could contribute to overcome current limitations in the gene therapy field.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Ricobaraza A,Gonzalez-Aparicio M,Mora-Jimenez L,Lumbreras S,Hernandez-Alcoceba R

doi

10.3390/ijms21103643

subject

Has Abstract

pub_date

2020-05-21 00:00:00

issue

10

issn

1422-0067

pii

ijms21103643

journal_volume

21

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population.

    abstract：:Studies indicate the heritable nature of affective temperament, which shows personality traits predisposing to the development of mental disorders. Dopaminergic gene polymorphisms such as DRD4, COMTVal158Met, and DAT1 have been linked to affective disorders in obesity. Due to possible correlation between the aforement...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20081847

    authors： Lesiewska N,Borkowska A,Junik R,Kamińska A,Pulkowska-Ulfig J,Tretyn A,Bieliński M

    更新日期：2019-04-15 00:00:00

  • Abnormal unsaturated fatty acid metabolism in cystic fibrosis: biochemical mechanisms and clinical implications.

    abstract：:Cystic fibrosis is an inherited multi-organ disorder caused by mutations in the CFTR gene. Patients with this disease exhibit characteristic abnormalities in the levels of unsaturated fatty acids in blood and tissue. Recent studies have uncovered an underlying biochemical mechanism for some of these changes, namely in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms150916083

    authors： Seegmiller AC

    更新日期：2014-09-11 00:00:00

  • Carbapenems to Treat Multidrug and Extensively Drug-Resistant Tuberculosis: A Systematic Review.

    abstract：BACKGROUND:Carbapenems (ertapenem, imipenem, meropenem) are used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB), even if the published evidence is limited, particularly when it is otherwise difficult to identify the recommended four active drugs to be included in the regimen. N...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17030373

    authors： Sotgiu G,D'Ambrosio L,Centis R,Tiberi S,Esposito S,Dore S,Spanevello A,Migliori GB

    更新日期：2016-03-12 00:00:00

  • Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals.

    abstract：:In a previous study on chromate toxicity, an increase in the 2Fe2S electron paramagnetic resonance (EPR) signal from mitochondria was found upon addition of chromate to human bronchial epithelial cells and bovine airway tissue ex vivo. This study was undertaken to show that a chromate-induced increase in the 2Fe2S EPR...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051143

    authors： Antholine WE,Vasquez-Vivar J,Quirk BJ,Whelan HT,Wu PK,Park JI,Myers CR

    更新日期：2019-03-06 00:00:00

  • In Vitro Evaluation of Gentamicin or Vancomycin Containing Bone Graft Substitute in the Prevention of Orthopedic Implant-Related Infections.

    abstract：:Antibiotic-loaded bone graft substitutes are attractive clinical options and have been used for years either for prophylaxis or therapy for periprosthetic and fracture-related infections. Calcium sulfate and hydroxyapatite can be combined in an injectable and moldable bone graft substitute that provides dead space man...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21239250

    authors： Bidossi A,Bottagisio M,Logoluso N,De Vecchi E

    更新日期：2020-12-04 00:00:00

  • Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala).

    abstract：:Blunt snout bream (Megalobrama amblycephala) is a widely favored herbivorous fish species and is a frequentlyused fish model for studying the metabolism physiology. This study aimed to provide a comprehensive illustration of the mechanisms of a high-starch diet (HSD) induced lipid metabolic disorder by identifying mic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061161

    authors： Miao LH,Lin Y,Pan WJ,Huang X,Ge XP,Ren MC,Zhou QL,Liu B

    更新日期：2017-05-31 00:00:00

  • P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura.

    abstract：:Bombyx mori doublesex (Bmdsx) functions as a double-switch gene in the final step of the sex-determination cascade in the silkworm Bombyx mori. The P-element somatic inhibitor (PSI) protein in B. mori interacts with Bmdsx pre-mRNA in CE1 as an exonic splicing silencer to promote male-specific splicing of Bmdsx. Howeve...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092361

    authors： Wang Y,Zhao Q,Wan QX,Wang KX,Zha XF

    更新日期：2019-05-13 00:00:00

  • The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective.

    abstract：:Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix upon exposure to met...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21030980

    authors： Hou YC,Lu CL,Yuan TH,Liao MT,Chao CT,Lu KC

    更新日期：2020-02-01 00:00:00

  • Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells.

    abstract：:CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the motility of breast cancer cells. Alisma canaliculatum is a herb that has been used as a traditional medicine for thousands of years in Korea and China. Whether A. canaliculatum inhibits the motil...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19092607

    authors： Choi J,Ahn SS,Lim Y,Lee YH,Shin SY

    更新日期：2018-09-03 00:00:00

  • The tRNA-dependent biosynthesis of modified cyclic dipeptides.

    abstract：:In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnove...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms150814610

    authors： Giessen TW,Marahiel MA

    更新日期：2014-08-21 00:00:00

  • Synthesis of Fluorescent Dansyl Derivatives of Methoxyamine and Diphenylhydrazine as Free Radical Precursors.

    abstract：:Starting from dansyl-chloride, in reaction with 1,1-diphenylhydrazine and methoxyamine, two new fluorescent derivatives 1 and 2 were obtained and characterized by NMR, IR, UV-Vis, HR-MS, and fluorescence spectroscopy. The single-crystal X-ray structure was obtained for compound 2. Both compounds generate free radicals...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21103559

    authors： Patrascu B,Mocanu S,Coman A,Madalan AM,Popescu C,Paun A,Matache M,Ionita P

    更新日期：2020-05-18 00:00:00

  • Sedoheptulose-1,7-Bisphosphatase is Involved in Methyl Jasmonate- and Dark-Induced Leaf Senescence in Tomato Plants.

    abstract：:Leaf senescence represents the final stage of leaf development and is regulated by diverse internal and environmental factors. Jasmonates (JAs) have been demonstrated to induce leaf senescence in several species; however, the mechanisms of JA-induced leaf senescence remain largely unknown in tomato plants (Solanum lyc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19113673

    authors： Ding F,Wang M,Zhang S

    更新日期：2018-11-20 00:00:00

  • Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus.

    abstract：:The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localizat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20225679

    authors： Navarro Quiroz E,Chavez-Estrada V,Macias-Ochoa K,Ayala-Navarro MF,Flores-Aguilar AS,Morales-Navarrete F,de la Cruz Lopez F,Gomez Escorcia L,Musso CG,Aroca Martinez G,Gonzales Torres H,Diaz Perez A,Cadena Bonfanti A,Sarmiento Gu

    更新日期：2019-11-13 00:00:00

  • The Supramolecular Buildup of Eumelanin: Structures, Mechanisms, Controllability.

    abstract：:Research on the supramolecular buildup of eumelanin has gained high momentum in the last years. Several new aspects regarding the involved structures and mechanisms have been established, which has led to a better understanding of the entire process. This review intends to provide a clearly laid-out summary of previou...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18091901

    authors： Büngeler A,Hämisch B,Strube OI

    更新日期：2017-09-06 00:00:00

  • Preparation and characterization of micronized artemisinin via a Rapid Expansion of Supercritical Solutions (RESS) Method.

    abstract：:The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13045060

    authors： Yu H,Zhao X,Zu Y,Zhang X,Zu B,Zhang X

    更新日期：2012-01-01 00:00:00

  • A specific oligodeoxynucleotide promotes the differentiation of osteoblasts via ERK and p38 MAPK pathways.

    abstract：:A specific oligodeoxynucleotide (ODN), ODN MT01, was found to have positive effects on the proliferation and activation of the osteoblast-like cell line MG 63. In this study, the detailed signaling pathways in which ODN MT01 promoted the differentiation of osteoblasts were systematically examined. ODN MT01 enhanced th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13077902

    authors： Hou X,Shen Y,Zhang C,Zhang L,Qin Y,Yu Y,Wang L,Sun X

    更新日期：2012-01-01 00:00:00

  • Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS.

    abstract：:The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21197157

    authors： Unfer V,Dinicola S,Laganà AS,Bizzarri M

    更新日期：2020-09-28 00:00:00

  • Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.

    abstract：:Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,多中心研究

    doi：10.3390/ijms18040837

    authors： Almeida AM,Prebet T,Itzykson R,Ramos F,Al-Ali H,Shammo J,Pinto R,Maurillo L,Wetzel J,Musto P,Van De Loosdrecht AA,Costa MJ,Esteves S,Burgstaller S,Stauder R,Autzinger EM,Lang A,Krippl P,Geissler D,Falantes JF,Pedr

    更新日期：2017-04-14 00:00:00

  • Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition.

    abstract：BACKGROUND:This study aims to investigate: (a) the putative association between the presence of microcalcifications and the expression of both epithelial-to-mesenchymal transition and bone biomarkers, (b) the role of microcalcifications in the breast osteoblast-like cells (BOLCs) formation, and (c) the association betw...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20225633

    authors： Scimeca M,Bonfiglio R,Menichini E,Albonici L,Urbano N,De Caro MT,Mauriello A,Schillaci O,Gambacurta A,Bonanno E

    更新日期：2019-11-11 00:00:00

  • Intra-Genomic Internal Transcribed Spacer Region Sequence Heterogeneity and Molecular Diagnosis in Clinical Microbiology.

    abstract：:Internal transcribed spacer region (ITS) sequencing is the most extensively used technology for accurate molecular identification of fungal pathogens in clinical microbiology laboratories. Intra-genomic ITS sequence heterogeneity, which makes fungal identification based on direct sequencing of PCR products difficult, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161025067

    authors： Zhao Y,Tsang CC,Xiao M,Cheng J,Xu Y,Lau SK,Woo PC

    更新日期：2015-10-22 00:00:00

  • NOD-like receptors in intestinal homeostasis and epithelial tissue repair.

    abstract：:The intestinal epithelium constitutes a dynamic physical barrier segregating the luminal content from the underlying mucosal tissue. Following injury, the epithelial integrity is restored by rapid migration of intestinal epithelial cells (IECs) across the denuded area in a process known as wound healing. Hence, throug...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms15069594

    authors： Parlato M,Yeretssian G

    更新日期：2014-05-30 00:00:00

  • Study on Thermal Decomposition Behaviors of Terpolymers of Carbon Dioxide, Propylene Oxide, and Cyclohexene Oxide.

    abstract：:The terpolymerization of carbon dioxide (CO₂), propylene oxide (PO), and cyclohexene oxide (CHO) were performed by both random polymerization and block polymerization to synthesize the random poly (propylene cyclohexene carbonate) (PPCHC), di-block polymers of poly (propylene carbonate⁻cyclohexyl carbonate) (PPC-PCHC)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123723

    authors： Chen S,Xiao M,Sun L,Meng Y

    更新日期：2018-11-23 00:00:00

  • Probing Protein Glycation by Chromatography and Mass Spectrometry: Analysis of Glycation Adducts.

    abstract：:Glycation is a non-enzymatic post-translational modification of proteins, formed by the reaction of reducing sugars and α-dicarbonyl products of their degradation with amino and guanidino groups of proteins. Resulted early glycation products are readily involved in further transformation, yielding a heterogeneous grou...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18122557

    authors： Soboleva A,Vikhnina M,Grishina T,Frolov A

    更新日期：2017-11-28 00:00:00

  • The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease.

    abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor presentations and a multitude of non-motor manifestations. There are two neuropathological hallmarks of PD, the dopaminergic neuronal loss and the alp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20215312

    authors： Lin KJ,Lin KL,Chen SD,Liou CW,Chuang YC,Lin HY,Lin TK

    更新日期：2019-10-25 00:00:00

  • EbARC1, an E3 Ubiquitin Ligase Gene in Erigeron breviscapus, Confers Self-Incompatibility in Transgenic Arabidopsis thaliana.

    abstract：:Erigeron breviscapus (Vant.) Hand.-Mazz. is a famous traditional Chinese medicine that has positive effects on the treatment of cardiovascular and cerebrovascular diseases. With the increase of market demand (RMB 500 million per year) and the sharp decrease of wild resources, it is an urgent task to cultivate high-qua...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041458

    authors： Chen M,Fan W,Hao B,Zhang W,Yan M,Zhao Y,Liang Y,Liu G,Lu Y,Zhang G,Zhao Z,Hu Y,Yang S

    更新日期：2020-02-20 00:00:00

  • Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model.

    abstract：:Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo. To avoid receptor interference and enable dual vector co-infection with MLV-RRV, we have developed another R...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041433

    authors： Chen SH,Sun JM,Chen BM,Lin SC,Chang HF,Collins S,Chang D,Wu SF,Lu YC,Wang W,Chen TC,Kasahara N,Wang HE,Tai CK

    更新日期：2020-02-20 00:00:00

  • Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-κB Pathways.

    abstract：:Oxymatrine (OMT) is a strong immunosuppressive agent that has been used in the clinic for many years. In the present study, by using plaque inhibition, luciferase reporter plasmids, qRT-PCR, western blotting, and ELISA assays, we have investigated the effect and mechanism of OMT on influenza A virus (IAV) replication ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19040965

    authors： Dai JP,Wang QW,Su Y,Gu LM,Deng HX,Chen XX,Li WZ,Li KS

    更新日期：2018-03-23 00:00:00

  • Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model.

    abstract：:Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome and less DIND (delayed ischemic neurological deficits). In rat experiments, enhanced axonal sprouting and higher survival of motoneurons was demonstrated after cutting or crushing the fac...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151018453

    authors： Herzfeld E,Strauss C,Simmermacher S,Bork K,Horstkorte R,Dehghani F,Scheller C

    更新日期：2014-10-14 00:00:00

  • Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation.

    abstract：:Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010164

    authors： Lkhagvadorj K,Zeng Z,Meyer KF,Verweij LP,Kooistra W,Reinders-Luinge M,Dijkhuizen HW,de Graaf IAM,Plösch T,Hylkema MN

    更新日期：2020-12-26 00:00:00

  • Homeostatic Model Assessment of Insulin Resistance for Predicting the Recurrence of Hepatocellular Carcinoma after Curative Treatment.

    abstract：:Diabetes mellitus (DM) is a risk factor for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the impact of the disorder of glucose metabolism on the recurrence of HCC after curative treatment. Two hundred and eleven patients with HCC who received curative treatment in our hospital from 2006...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030605

    authors： Imai K,Takai K,Hanai T,Suetsugu A,Shiraki M,Shimizu M

    更新日期：2019-01-30 00:00:00