Abstract：
:Research on the supramolecular buildup of eumelanin has gained high momentum in the last years. Several new aspects regarding the involved structures and mechanisms have been established, which has led to a better understanding of the entire process. This review intends to provide a clearly laid-out summary of previous and new findings regarding structures, mechanisms, and controllability. With respect to materials applications, the aspect of controllability is of supreme importance. A focus of this review is therefore set on a novel method with high potential for specific synthesis of various, isolated particle morphologies. Finally, open questions and possibilities for their elucidation are discussed.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Büngeler A,Hämisch B,Strube OIdoi
10.3390/ijms18091901subject
Has Abstractpub_date
2017-09-06 00:00:00issue
9issn
1422-0067pii
ijms18091901journal_volume
18pub_type
杂志文章,评审abstract：:Several studies have suggested that there is a link between membrane attack complex (MAC) deposition in the retina and the progression of diabetic retinopathy (DR). Our recent investigation demonstrated that circulating IgG-laden extracellular vesicles contribute to an increase in retinal vascular permeability in DR t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051693
更新日期：2020-03-01 00:00:00
abstract：:We aimed to validate the effect of non-canonical splice site variants in the RPGR gene in five patients from four families diagnosed with retinitis pigmentosa. Four variants located in intron 2 (c.154 + 3_154 + 6del), intron 3 (c.247 + 5G>A), intron 7 (c.779-5T>G), and intron 13 (c.1573-12A>G), respectively, were anal...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020850
更新日期：2021-01-16 00:00:00
abstract：:Recessively-inherited NR2E3 gene mutations cause an unusual retinopathy with abnormally-increased short-wavelength sensitive cone (S-cone) function, in addition to reduced rod and long/middle-wavelength sensitive cone (L/M-cone) function. Progress toward clinical trials to treat patients with this otherwise incurable ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102497
更新日期：2019-05-21 00:00:00
abstract：:Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color vari...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041209
更新日期：2018-04-16 00:00:00
abstract：:We identified and characterized the TcLgl gene putatively encoding lethal giant larvae (Lgl) protein from the red flour beetle (Tribolium castaneum). Analyses of developmental stage and tissue-specific expression patterns revealed that TcLgl was constitutively expressed. To examine the role of TcLgl in insect developm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15046880
更新日期：2014-04-22 00:00:00
abstract：:The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061107
更新日期：2017-05-23 00:00:00
abstract：:McArdle disease, also known as glycogen storage disease type V (GSDV), is characterized by exercise intolerance, the second wind phenomenon, and high serum creatine kinase activity. Here, we recapitulate PYGM mutations in the population responsible for this disease. Traditionally, McArdle disease has been considered a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20235919
更新日期：2019-11-25 00:00:00
abstract：:Intrinsically disordered proteins mediate crucial biological functions through their interactions with other proteins. Mutual synergistic folding (MSF) occurs when all interacting proteins are disordered, folding into a stable structure in the course of the complex formation. In these cases, the folding and binding pr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215460
更新日期：2019-11-01 00:00:00
abstract：:As key cellular elements of hemostasis, platelets represent a primary target for thrombosis and bleeding management. Currently, therapeutic manipulations of platelet function (antithrombotic drugs) and count (platelet transfusion) are performed with limited or no real-time monitoring of the desired outcome at the poin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041174
更新日期：2020-02-11 00:00:00
abstract：:: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic revie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030907
更新日期：2020-01-30 00:00:00
abstract：:RNA binding protein (RBPs) and microRNAs (miRNAs or miRs) are post-transcriptional regulators of gene expression that are implicated in development of cancers. Although their individual roles have been studied, the crosstalk between RBPs and miRNAs is under intense investigation. Here, we show that in breast cancer ce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047112
更新日期：2015-03-30 00:00:00
abstract：:Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12084861
更新日期：2011-01-01 00:00:00
abstract：:Sericin is a major constituent of silk produced by silkworms. We previously found that the instillation of sericin enhanced the proliferation of corneal epithelial cells, and acted to promote corneal wound healing in both normal and diabetic model rats. However, the mechanisms by which sericin promotes the proliferati...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041123
更新日期：2018-04-09 00:00:00
abstract：:The iliotibial band (ITB) is a suitable scaffold for anterior cruciate ligament (ACL) reconstruction, providing a sufficient mechanical resistance to loading. Hence, ITB-derived fibroblasts attract interest for ligament tissue engineering but have so far not been characterized. This present study aimed at characterizi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20081972
更新日期：2019-04-22 00:00:00
abstract：:Poly(glutamic acid) has been studied with a nanosecond T-jump experiment. A new experimental set-up based on the frequency-quadrupling of an 82 MHz Titanium-Sapphire laser allows rapid CD measurements to be performed. Combining time-resolved absorption and circular dichroism at 204 and 220 nm, we are able to measure p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13022239
更新日期：2012-01-01 00:00:00
abstract：:Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type I (HT1), resulting ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228719
更新日期：2020-11-18 00:00:00
abstract：:Defensins are small and rather ubiquitous cysteine-rich anti-microbial peptides. These proteins may act against pathogenic microorganisms either directly (by binding and disrupting membranes) or indirectly (as signaling molecules that participate in the organization of the cellular defense). Even though defensins are ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249380
更新日期：2020-12-09 00:00:00
abstract：:This paper aims at analysing the synthesis of flavonoids, their import and export in plant cell compartments, as well as their involvement in the response to stress, with particular reference to grapevine (Vitis vinifera L.). A multidrug and toxic compound extrusion (MATE) as well as ABC transporters have been demonst...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140714950
更新日期：2013-07-17 00:00:00
abstract：:Zinc (Zn) and iron (Fe) are essential but are sometimes deficient in humans, while cadmium (Cd) is toxic if it accumulates in the liver and kidneys at high levels. All three are contained in the grains of rice, a staple cereal. Zn and Fe concentrations in rice grains harvested under different levels of soil/hydroponic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160819111
更新日期：2015-08-13 00:00:00
abstract：:Hypoxic-ischemic encephalopathy (HIE) resulting from asphyxia in the peripartum period is the most common cause of neonatal brain damage and can result in significant neurologic sequelae, including cerebral palsy. Currently therapeutic hypothermia is the only accepted treatment in addition to supportive care for infan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010017
更新日期：2016-12-22 00:00:00
abstract：:In the absence of lymphatics, fluid and solutes such as amyloid-β (Aβ) are eliminated from the brain along basement membranes in the walls of cerebral capillaries and arteries-the Intramural Peri-Arterial Drainage (IPAD) pathway. IPAD fails with age and insoluble Aβ is deposited as plaques in the brain and in IPAD pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041225
更新日期：2020-02-12 00:00:00
abstract：:One of the ultimate goals of wound healing research is to find effective healing techniques that utilize the regeneration of similar tissues. This involves the modification of various wound dressing biomaterials for proper wound management. The biopolymer chitosan (beta-1,4-D-glucosamine) has natural biocompatibility ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10031300
更新日期：2009-03-01 00:00:00
abstract：:Various strategies have been employed to speed tissue regeneration using bioactive molecules. Interestingly, platelet concentrates derived from a patient's own blood have been utilized as a regenerative strategy in recent years. In the present study, a novel liquid platelet formulation prepared without the use of anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020331
更新日期：2017-02-04 00:00:00
abstract：:Bifidobacterium bifidum BGN4 is a probiotic strain that has been used as a major ingredient to produce nutraceutical products and as a dairy starter since 2000. The various bio-functional effects and potential for industrial application of B. bifidum BGN4 has been characterized and proven by in vitro (i.e., phytochemi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17091544
更新日期：2016-09-14 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for pulmonary fibrosis will require an improved understanding of its molecular patho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020643
更新日期：2020-01-18 00:00:00
abstract：:The aqueous solubility (logW) and n-octanol/water partition coefficient (logP(OW)) are important properties for pharmacology, toxicology and medicinal chemistry. Based on an understanding of the dissolution process, the frontier orbital interaction model was suggested in the present paper to describe the solvent-solut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9060962
更新日期：2008-06-01 00:00:00
abstract：:Grape hyacinth (Muscari spp.) is a popular ornamental plant with bulbous flowers noted for their rich blue color. Muscari species have been thought to accumulate delphinidin and cyanidin rather than pelargonidin-type anthocyanins because their dihydroflavonol 4-reductase (DFR) does not efficiently reduce dihydrokaempf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194743
更新日期：2019-09-24 00:00:00
abstract：:Articular cartilage (AC) is an avascular tissue composed of scattered chondrocytes embedded in a dense extracellular matrix, in which nourishment takes place via the synovial fluid at the surface. AC has a limited intrinsic healing capacity, and thus mainly surgical techniques have been used to relieve pain and improv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218249
更新日期：2020-11-04 00:00:00
abstract：:Mast cells are pluripotent leukocytes that reside in the mucosa and connective tissue. Recent studies show an increased prevalence of cardiovascular disease among patients with mastocytosis, which is a hematological disease that is characterized by the accumulation of mast cells due to clonal proliferation. This assoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143395
更新日期：2019-07-10 00:00:00
abstract：:The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020342
更新日期：2017-02-07 00:00:00
