Abstract：
:The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the differential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Navarro Quiroz E,Chavez-Estrada V,Macias-Ochoa K,Ayala-Navarro MF,Flores-Aguilar AS,Morales-Navarrete F,de la Cruz Lopez F,Gomez Escorcia L,Musso CG,Aroca Martinez G,Gonzales Torres H,Diaz Perez A,Cadena Bonfanti A,Sarmiento Gudoi
10.3390/ijms20225679subject
Has Abstractpub_date
2019-11-13 00:00:00issue
22issn
1422-0067pii
ijms20225679journal_volume
20pub_type
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