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Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model.

Abstract：

:Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome and less DIND (delayed ischemic neurological deficits). In rat experiments, enhanced axonal sprouting and higher survival of motoneurons was demonstrated after cutting or crushing the facial nerve by nimodipine. These results were confirmed in clinical trials following vestibular Schwannoma surgery. The mechanism of the protective competence of nimodipine is unknown. Therefore, in this study, we established an in vitro model to examine the survival of Neuro2a cells after different stress stimuli occurring during surgery with or without nimodipine. Nimodipine significantly decreased ethanol-induced cell death of cells up to approximately 9% in all tested concentrations. Heat-induced cell death was diminished by approximately 2.5% by nimodipine. Cell death induced by mechanical treatment was reduced up to 15% by nimodipine. Our findings indicate that nimodipine rescues Neuro2a cells faintly, but significantly, from ethanol-, heat- and mechanically-induced cell death to different extents in a dosage-dependent manner. This model seems suitable for further investigation of the molecular mechanisms involved in the neuroprotective signal pathways influenced by nimodipine.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Herzfeld E,Strauss C,Simmermacher S,Bork K,Horstkorte R,Dehghani F,Scheller C

doi

10.3390/ijms151018453

subject

Has Abstract

pub_date

2014-10-14 00:00:00

pages

18453-65

issue

10

issn

1422-0067

pii

ijms151018453

journal_volume

15

pub_type

杂志文章

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