当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Intra-Articular Formulation of GE11-PLGA Conjugate-Based NPs for Dexamethasone Selective Targeting-In Vitro Evaluation.

Intra-Articular Formulation of GE11-PLGA Conjugate-Based NPs for Dexamethasone Selective Targeting-In Vitro Evaluation.

Abstract：

:Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-articular administration and for selectively targeting Epidermal Growth Factor Receptor (EGFR). GE11-PLGA conjugate-based NPs are specifically uptaken by EGFR-overexpressed fibroblast; such as synoviocytes; which are the primarily cellular component involved in the development of destructive joint inflammation. The selective uptake could help to tune drug effectiveness in joints and to decrease local and systemic side effects. Dexamethasone (DXM) is a glucorticoid drug commonly used in joint disease treatment for both systemic and local administration route. In the present research; DXM was efficiently loaded into GE11-PLGA conjugate-based NPs through an eco-friendly nanoprecipitation method set up for this purpose. DXM loaded GE11-PLGA conjugate-based NPs revealed satisfactory ex vivo cytocompatibility; with proper size (≤150 nm) and good dimensional stability in synovial fluid. Intra-articular formulation was developed embedding DXM loaded GE11-PLGA conjugate-based NPs into thermosetting chitosan-based hydrogel; forming a biocompatible composite hydrogel able to quickly turn from liquid state into gel state at physiological temperature; within 15 min. Moreover; the use of thermosetting chitosan-based hydrogel extends the local release of active agent; DXM.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Chiesa E,Pisani S,Colzani B,Dorati R,Conti B,Modena T,Braekmans K,Genta I

doi

10.3390/ijms19082304

subject

Has Abstract

pub_date

2018-08-06 00:00:00

issue

8

issn

1422-0067

pii

ijms19082304

journal_volume

19

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Cadmium Exposure and Risk of Breast Cancer by Histological and Tumor Receptor Subtype in White Caucasian Women: A Hospital-Based Case-Control Study.

    abstract：:As the majority of experimental studies suggest cadmium being metalloestrogen, we examined cadmium/breast cancer (BC) association by histological and tumor receptor subtype in 509 invasive BC patients and 1170 controls. Urinary cadmium was determined by atomic absorption spectrometry, and categorized using tertiles of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20123029

    authors： Strumylaite L,Kregzdyte R,Bogusevicius A,Poskiene L,Baranauskiene D,Pranys D

    更新日期：2019-06-21 00:00:00

  • Nanoparticles and Colloidal Hydrogels of Chitosan-Caseinate Polyelectrolyte Complexes for Drug-Controlled Release Applications.

    abstract：:Chitosan-caseinate nanoparticles were synthesized by polyelectrolyte complex (PEC) formation. Caseinate is an anionic micellar nanocolloid in aqueous solutions, which association with the polycationic chitosan yielded polyelectrolyte complexes with caseinate cores surrounded by a chitosan corona. The pre-structuration...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165602

    authors： Lall A,Kamdem Tamo A,Doench I,David L,Nunes de Oliveira P,Gorzelanny C,Osorio-Madrazo A

    更新日期：2020-08-05 00:00:00

  • Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA).

    abstract：:Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate comple...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17071185

    authors： Neiser S,Koskenkorva TS,Schwarz K,Wilhelm M,Burckhardt S

    更新日期：2016-07-21 00:00:00

  • Healing of Osteochondral Defects Implanted with Biomimetic Scaffolds of Poly(ε-Caprolactone)/Hydroxyapatite and Glycidyl-Methacrylate-Modified Hyaluronic Acid in a Minipig.

    abstract：:Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(e...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19041125

    authors： Hsieh YH,Shen BY,Wang YH,Lin B,Lee HM,Hsieh MF

    更新日期：2018-04-09 00:00:00

  • DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond.

    abstract：:Schizophrenia and autism spectrum disorder (ASD) are multi-factorial and multi-symptomatic psychiatric disorders, each affecting 0.5%-1% of the population worldwide. Both are characterized by impairments in cognitive functions, emotions and behaviour, and they undermine basic human processes of perception and judgment...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17060856

    authors： Markkanen E,Meyer U,Dianov GL

    更新日期：2016-06-01 00:00:00

  • Evidence of Altered Glycosylation of Serum Proteins Prior to Pancreatic Cancer Diagnosis.

    abstract：:Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to f...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18122670

    authors： Krishnan S,Whitwell HJ,Cuenco J,Gentry-Maharaj A,Menon U,Pereira SP,Gaspari M,Timms JF

    更新日期：2017-12-09 00:00:00

  • Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis.

    abstract：:Streptococcus pneumoniae is a major meningitis-causing pathogen globally, bringing about significant morbidity and mortality, as well as long-term neurological sequelae in almost half of the survivors. Subsequent to nasopharyngeal colonisation and systemic invasion, translocation across the blood‒brain barrier (BBB) b...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19113555

    authors： Yau B,Hunt NH,Mitchell AJ,Too LK

    更新日期：2018-11-11 00:00:00

  • Theoretical and experimental spectroscopic analysis of cyano-substituted styrylpyridine compounds.

    abstract：:A combined theoretical and experimental study on the structure, infrared, UV-Vis and 1H NMR data of trans-2-(m-cyanostyryl)pyridine, trans-2-[3-methyl-(m-cyanostyryl)]pyridine and trans-4-(m-cyanostyryl)pyridine is presented. The synthesis was carried out with an efficient Knoevenagel condensation using green chemist...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14024005

    authors： Castro ME,Percino MJ,Chapela VM,Ceron M,Soriano-Moro G,Lopez-Cruz J,Melendez FJ

    更新日期：2013-02-18 00:00:00

  • Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Heart Failure: Current Understanding for Basic to Clinical Relevance.

    abstract：:Heart failure (HF) is a rapidly growing global public health problem. Since HF results in high mortality and re-hospitalization, new effective treatments are desired. Although it remains controversial, omega 3 polyunsaturated fatty acids (n-3 PUFAs), such as the eicosapentaenoic acid and docosahexaenoic acid, have bee...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20164025

    authors： Sakamoto A,Saotome M,Iguchi K,Maekawa Y

    更新日期：2019-08-18 00:00:00

  • Platelet Induced Functional Alteration of CD4+ and CD8+ T Cells in HNSCC.

    abstract：:Platelets (PLT) are the second most abundant cell type in human blood and exert various immune-regulatory functions under both physiological and pathological conditions. In fact, immune cell regulation via platelets has been demonstrated in several studies within the past decade. However, the exact mechanisms behind T...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21207507

    authors： Polasky C,Wendt F,Pries R,Wollenberg B

    更新日期：2020-10-12 00:00:00

  • Genetic and Molecular Control of Floral Organ Identity in Cereals.

    abstract：:Grasses represent a major family of monocots comprising mostly cereals. When compared to their eudicot counterparts, cereals show a remarkable morphological diversity. Understanding the molecular basis of floral organ identity and inflorescence development is crucial to gain insight into the grain development for yiel...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20112743

    authors： Ali Z,Raza Q,Atif RM,Aslam U,Ajmal M,Chung G

    更新日期：2019-06-04 00:00:00

  • Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells.

    abstract：:The overexpressing ABCB1 transporter is one of the key factors leading to multidrug resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome ABCB1-mediated MDR. However, some inhibitors also work as a substrate of ABCB1, which indicates that in order to achieve an effective reversal dosage,...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041387

    authors： Wang J,Yang DH,Yang Y,Wang JQ,Cai CY,Lei ZN,Teng QX,Wu ZX,Zhao L,Chen ZS

    更新日期：2020-02-19 00:00:00

  • Stem cell tracking by nanotechnologies.

    abstract：:Advances in stem cell research have provided important understanding of the cell biology and offered great promise for developing new strategies for tissue regeneration. The beneficial effects of stem cell therapy depend also by the development of new approachs for the track of stem cells in living subjects over time ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms11031070

    authors： Villa C,Erratico S,Razini P,Fiori F,Rustichelli F,Torrente Y,Belicchi M

    更新日期：2010-03-12 00:00:00

  • Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.

    abstract：:Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 (DM1) and 2 (DM2). Current disease models for DM1 and DM2 propose a common pathomechanism, whereby the transcription of mutant DMPK (DM1) and CNB...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20133365

    authors： Sznajder ŁJ,Swanson MS

    更新日期：2019-07-09 00:00:00

  • Preparation and Characterization of Whey Protein Isolate-DIM Nanoparticles.

    abstract：:3,3'-Diindolylmethane (DIM) is a bioactive compound found in Cruciferous vegetables that possesses health benefits such as antioxidant, anticancer, and anti-inflammatory effects. However, hydrophobicity and photolabile limit its pharmaceutical applications. This study aims to prepare and characterize DIM-encapsulated ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20163917

    authors： Khan A,Wang C,Sun X,Killpartrick A,Guo M

    更新日期：2019-08-12 00:00:00

  • Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.

    abstract：:Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi bear dual specificity phosphatases (DUSPs) that act as MAP kinase phosphat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20071709

    authors： González-Rubio G,Fernández-Acero T,Martín H,Molina M

    更新日期：2019-04-05 00:00:00

  • High PD-L1 Expression Predicts for Worse Outcome of Leukemia Patients with Concomitant NPM1 and FLT3 Mutations.

    abstract：:Compared to solid tumors, the role of PD-L1 in hematological malignancies is less explored, and the knowledge in this area is mostly limited to lymphomas. However, several studies indicated that PD-L1 is also overexpressed in myeloid malignancies. Successful treatment of the acute myeloid leukemia (AML) is likely asso...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20112823

    authors： Brodská B,Otevřelová P,Šálek C,Fuchs O,Gašová Z,Kuželová K

    更新日期：2019-06-10 00:00:00

  • Soluble (Pro)renin Receptor and Obstructive Sleep Apnea Syndrome: Oxidative Stress in Brain?

    abstract：:(Pro)renin receptor ((P)RR) is a multi-functional molecule that is related to both the renin-angiotensin system (RAS) and vacuolar H⁺-ATPase (v-ATPase), an ATP-dependent multi-subunit proton pump. Soluble (P)RR (s(P)RR), which consists of the extracellular domain of (P)RR, is present in blood and urine. Elevated plasm...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18061313

    authors： Takahashi K,Ohba K,Tajima K,Nishijima T,Sakurai S

    更新日期：2017-06-20 00:00:00

  • miR-7 Knockdown by Peptide Nucleic Acids in the Ascidian Ciona intestinalis.

    abstract：:Peptide Nucleic Acids (PNAs) are synthetic mimics of natural oligonucleotides, which bind complementary DNA/RNA strands with high sequence specificity. They display numerous advantages, but in vivo applications are still rare. One of the main drawbacks of PNAs application is the poor cellular uptake that could be over...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20205127

    authors： Mercurio S,Cauteruccio S,Manenti R,Candiani S,Scarì G,Licandro E,Pennati R

    更新日期：2019-10-16 00:00:00

  • Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer.

    abstract：:5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment. The purpose of our study was to assess the feasibility of using quinacrine (QC) to ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184366

    authors： Kim HG,Kim CW,Lee DH,Lee JS,Oh ET,Park HJ

    更新日期：2019-09-05 00:00:00

  • Aedes albopictus Autophagy-Related Gene 8 (AaAtg8) Is Required to Confer Anti-Bacterial Gut Immunity.

    abstract：:Autophagy is an important process by which pathogens and damaged or unused organelles are eliminated. The role of autophagy in development and the immune response to pathogens is well established. Autophagy-related protein 8 (Atg8) is involved in the formation of the autophagosome and, with the help of the serine prot...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082944

    authors： Kim CE,Park KB,Ko HJ,Keshavarz M,Bae YM,Kim B,Patnaik BB,Jang HA,Lee YS,Han YS,Jo YH

    更新日期：2020-04-22 00:00:00

  • The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.

    abstract：:The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19040999

    authors： Gerbino A,Colella M

    更新日期：2018-03-27 00:00:00

  • The Salicylic Acid-Mediated Release of Plant Volatiles Affects the Host Choice of Bemisia tabaci.

    abstract：:The whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) causes serious crop losses worldwide by transmitting viruses. We have previously shown that salicylic acid (SA)-related plant defenses directly affect whiteflies. In this study, we applied exogenous SA to tomato plants in order to investigate the interac...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17071048

    authors： Shi X,Chen G,Tian L,Peng Z,Xie W,Wu Q,Wang S,Zhou X,Zhang Y

    更新日期：2016-06-30 00:00:00

  • Recurrent structural motifs in non-homologous protein structures.

    abstract：:We have extracted an extensive collection of recurrent structural motifs (RSMs), which consist of sequentially non-contiguous structural motifs (4-6 residues), each of which appears with very similar conformation in three or more mutually unrelated protein structures. We find that the proteins in our set are covered t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14047795

    authors： Johansson MU,Zoete V,Guex N

    更新日期：2013-04-10 00:00:00

  • Myosin Binding Protein-C Forms Amyloid-Like Aggregates In Vitro.

    abstract：:This work investigated in vitro aggregation and amyloid properties of skeletal myosin binding protein-C (sMyBP-C) interacting in vivo with proteins of thick and thin filaments in the sarcomeric A-disc. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) found a rapid (5-10 min) formation of large...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020731

    authors： Bobyleva LG,Shumeyko SA,Yakupova EI,Surin AK,Galzitskaya OV,Kihara H,Timchenko AA,Timchenko MA,Penkov NV,Nikulin AD,Suvorina MY,Molochkov NV,Lobanov MY,Fadeev RS,Vikhlyantsev IM,Bobylev AG

    更新日期：2021-01-13 00:00:00

  • cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators.

    abstract：:Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms-NO-GC1 and NO-GC2-are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered that work synergistically with NO to s...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082313

    authors： Peters S,Paolillo M,Mergia E,Koesling D,Kennel L,Schmidtko A,Russwurm M,Feil R

    更新日期：2018-08-07 00:00:00

  • The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester.

    abstract：:Creatine is a metabolite important for cellular energy homeostasis as it provides spatio-temporal adenosine triphosphate (ATP) buffering for cells with fluctuating energy demands. Here, we examined whether placental creatine metabolism was altered in cases of early-onset pre-eclampsia (PE), a condition known to cause ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21030806

    authors： Ellery SJ,Murthi P,Gatta PAD,May AK,Davies-Tuck ML,Kowalski GM,Callahan DL,Bruce CR,Wallace EM,Walker DW,Dickinson H,Snow RJ

    更新日期：2020-01-26 00:00:00

  • MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line.

    abstract：:MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiose...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160922137

    authors： Ma D,Jia H,Qin M,Dai W,Wang T,Liang E,Dong G,Wang Z,Zhang Z,Feng F

    更新日期：2015-09-14 00:00:00

  • Extended cleavage specificities of two mast cell chymase-related proteases and one granzyme B-like protease from the platypus, a monotreme.

    abstract：:Mast cells (MCs) are inflammatory cells primarily found in tissues in close contact with the external environment, such as the skin and the intestinal mucosa. They store large amounts of active components in cytoplasmic granules, ready for rapid release. The major protein content of these granules is proteases, which ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010319

    authors： Fu Z,Akula S,Thorpe M,Hellman L

    更新日期：2020-01-02 00:00:00

  • Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts.

    abstract：:Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene that belongs to the ELOVL family and regulates the synthesis of very-long-chain fatty acids (VLCFAs) and sphingolipids, from yeast to mammals. Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160716440

    authors： Wang W,He Q,Guo Z,Yang L,Bao L,Bao W,Zheng X,Wang Y,Wang Z

    更新日期：2015-07-20 00:00:00