当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Challenges in Promoting Mitochondrial Transplantation Therapy.

Challenges in Promoting Mitochondrial Transplantation Therapy.

Abstract：

:Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has been reported to be useful in the treatment of cardiac ischemic reperfusion injuries in human clinical trials and has also been shown to be useful in animal studies as a method for treating mitochondrial dysfunction in various tissues, including the heart, liver, lungs, and brain. On the other hand, there is no methodology for using preserved mitochondria. Research into the pharmaceutical formulation of mitochondria to promote mitochondrial transplantation therapy as the next step in treating many patients is urgently needed. In this review, we overview previous studies on the therapeutic effects of mitochondrial transplantation. We also discuss studies related to immune responses that occur during mitochondrial transplantation and methods for preserving mitochondria, which are key to their stability as medicines. Finally, we describe research related to mitochondrial targeting drug delivery systems (DDS) and discuss future perspectives of mitochondrial transplantation.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Yamada Y,Ito M,Arai M,Hibino M,Tsujioka T,Harashima H

doi

10.3390/ijms21176365

subject

Has Abstract

pub_date

2020-09-02 00:00:00

issue

17

issn

1422-0067

pii

ijms21176365

journal_volume

21

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H₁ Receptors.

    abstract：:Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H₁ receptors than (S)-cetirizine; ligand-receptor docking simulations have suggested the importance of the formation of a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19124067

    authors： Hishinuma S,Tamura Y,Kobayashi C,Akatsu C,Shoji M

    更新日期：2018-12-15 00:00:00

  • Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability.

    abstract：:The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell's DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, hav...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22010076

    authors： Morgan A,LeGresley S,Fischer C

    更新日期：2020-12-23 00:00:00

  • HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin.

    abstract：:HER2 (human epidermal growth factor receptor 2) activation is critical in breast cancer development. HER2 promotes cell proliferation, angiogenesis, survival, and metastasis by activation of PI3K/Akt, Ras/MEK/ERK, and JAK/STAT pathways. However, beyond these signaling molecules, the key proteins underlining HER2-media...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092223

    authors： Zeng P,Sun S,Li R,Xiao ZX,Chen H

    更新日期：2019-05-06 00:00:00

  • T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in Heart Failure.

    abstract：:Alterations of the β-adrenergic signalling, structural remodelling, and electrical failure of T-tubules are hallmarks of heart failure (HF). Here, we assess the effect of β-adrenoceptor activation on local Ca(2+) release in electrically coupled and uncoupled T-tubules in ventricular myocytes from HF rats. We employ an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17091471

    authors： Crocini C,Coppini R,Ferrantini C,Yan P,Loew LM,Poggesi C,Cerbai E,Pavone FS,Sacconi L

    更新日期：2016-09-03 00:00:00

  • Preparation and characterization of micronized artemisinin via a Rapid Expansion of Supercritical Solutions (RESS) Method.

    abstract：:The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13045060

    authors： Yu H,Zhao X,Zu Y,Zhang X,Zu B,Zhang X

    更新日期：2012-01-01 00:00:00

  • The effect of sericin from various extraction methods on cell viability and collagen production.

    abstract：:Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms11052200

    authors： Aramwit P,Kanokpanont S,Nakpheng T,Srichana T

    更新日期：2010-05-20 00:00:00

  • CD155: A Multi-Functional Molecule in Tumor Progression.

    abstract：:CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21030922

    authors： Molfetta R,Zitti B,Lecce M,Milito ND,Stabile H,Fionda C,Cippitelli M,Gismondi A,Santoni A,Paolini R

    更新日期：2020-01-30 00:00:00

  • Overexpression of the Stress-Inducible SsMAX2 Promotes Drought and Salt Resistance via the Regulation of Redox Homeostasis in Arabidopsis.

    abstract：:Recent studies have demonstrated that strigolactones (SLs) also participate in the regulation of stress adaptation; however, the regulatory mechanism remains elusive. In this study, the homolog of More Axillary Branches 2, which encodes a key component in SL signaling, in the perennial oil plant Sapium sebiferum was i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20040837

    authors： Wang Q,Ni J,Shah F,Liu W,Wang D,Yao Y,Hu H,Huang S,Hou J,Fu S,Wu L

    更新日期：2019-02-15 00:00:00

  • EGF Receptor Stalls upon Activation as Evidenced by Complementary Fluorescence Correlation Spectroscopy and Fluorescence Recovery after Photobleaching Measurements.

    abstract：:To elucidate the molecular details of the activation-associated clustering of epidermal growth factor receptors (EGFRs), the time course of the mobility and aggregation states of eGFP tagged EGFR in the membranes of Chinese hamster ovary (CHO) cells was assessed by in situ mobility assays. Fluorescence correlation spe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133370

    authors： Vámosi G,Friedländer-Brock E,Ibrahim SM,Brock R,Szöllősi J,Vereb G

    更新日期：2019-07-09 00:00:00

  • What do effective treatments for multiple sclerosis tell us about the molecular mechanisms involved in pathogenesis?

    abstract：:Multiple sclerosis is a potentially debilitating disease of the central nervous system. A concerted program of research by many centers around the world has consistently demonstrated the importance of the immune system in its pathogenesis. This knowledge has led to the formal testing of a number of therapeutic agents ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms131012665

    authors： Buzzard KA,Broadley SA,Butzkueven H

    更新日期：2012-10-04 00:00:00

  • Evolutionary Toxicogenomics of the Striped Killifish (Fundulus majalis) in the New Bedford Harbor (Massachusetts, USA).

    abstract：:In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051129

    authors： Ruggeri P,Du X,Crawford DL,Oleksiak MF

    更新日期：2019-03-05 00:00:00

  • Adiponectin in Chronic Kidney Disease.

    abstract：:Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21249375

    authors： Przybyciński J,Dziedziejko V,Puchałowicz K,Domański L,Pawlik A

    更新日期：2020-12-09 00:00:00

  • Triphenylamine-Merocyanine-Based D1-A1-π-A2/A3-D2 Chromophore System: Synthesis, Optoelectronic, and Theoretical Studies.

    abstract：:donor⁻acceptorDonor⁻acceptor⁻π⁻acceptor⁻donor (D1-A1-π-A2/A3-D2)-type small molecules, such TPA-MC-2 and TPA-MC-3, were designed and synthesized starting from donor-substituted alkynes (TPA-MC-1) via [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimeth...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20071621

    authors： Srinivasa Rao P,L Puyad A,V Bhosale S,V Bhosale S

    更新日期：2019-04-01 00:00:00

  • Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

    abstract：:Lewy body disorders (LBD) include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). They are synucleinopathies with a heterogeneous clinical manifestation. As a cause of neuropathological overlap with other neurodegenerative diseases, the establishment of a correct clinical diagnosis is still challenging, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21134718

    authors： Urbizu A,Beyer K

    更新日期：2020-07-02 00:00:00

  • Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa.

    abstract：:The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years, its initial evolutionary history is not yet fully elucidated. Using bioinformat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010006

    authors： Bartas M,Brázda V,Červeň J,Pečinka P

    更新日期：2019-12-18 00:00:00

  • Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals.

    abstract：:In a previous study on chromate toxicity, an increase in the 2Fe2S electron paramagnetic resonance (EPR) signal from mitochondria was found upon addition of chromate to human bronchial epithelial cells and bovine airway tissue ex vivo. This study was undertaken to show that a chromate-induced increase in the 2Fe2S EPR...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051143

    authors： Antholine WE,Vasquez-Vivar J,Quirk BJ,Whelan HT,Wu PK,Park JI,Myers CR

    更新日期：2019-03-06 00:00:00

  • Special Issue of International Journal of Molecular Sciences (IJMS) "Purinergic P2 Receptors: Structure and Function".

    abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms22010383

    authors： Zemkova H

    更新日期：2020-12-31 00:00:00

  • Dendritic cells and multiple sclerosis: disease, tolerance and therapy.

    abstract：:Multiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact. The majority of therapies for this disease were developed in, or are beneficial in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. While known...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms14010547

    authors： Mohammad MG,Hassanpour M,Tsai VW,Li H,Ruitenberg MJ,Booth DW,Serrats J,Hart PH,Symonds GP,Sawchenko PE,Breit SN,Brown DA

    更新日期：2012-12-27 00:00:00

  • Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID.

    abstract：:Small interfering RNA (siRNA) has been recognized as a powerful gene-silencing tool. For therapeutic application, chemical modification is often required to improve the properties of siRNA, including its nuclease resistance, activity, off-target effects, and tissue distribution. Careful siRNA guide strand selection in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155218

    authors： Kamiya Y,Takeyama Y,Mizuno T,Satoh F,Asanuma H

    更新日期：2020-07-23 00:00:00

  • Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells.

    abstract：:Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1-the most studied hnRNP-is an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20030745

    authors： Shishkin SS,Kovalev LI,Pashintseva NV,Kovaleva MA,Lisitskaya K

    更新日期：2019-02-10 00:00:00

  • The Impact of Lidocaine on Adipose-Derived Stem Cells in Human Adipose Tissue Harvested by Liposuction and Used for Lipotransfer.

    abstract：:The local anesthetic lidocaine, which has been used extensively during liposuction, has been reported to have cytotoxic effects and therefore would be unsuitable for use in autologous lipotransfer. We evaluated the effect of lidocaine on the distribution, number, and viability of adipose-derived stem cells (ASCs), pre...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082869

    authors： Grambow F,Rutkowski R,Podmelle F,Schmoeckel K,Siegerist F,Domanski G,Schuster MW,Domanska G

    更新日期：2020-04-20 00:00:00

  • Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis.

    abstract：:Hepatocellular carcinoma (HCC) is a deadly form of liver malignancy with limited treatment options. Amplification and/or overexpression of c-MYC is one of the most frequent genetic events in human HCC. The mammalian target of Rapamycin Complex 1 (mTORC1) is a major functional axis regulating various aspects of cellula...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228467

    authors： Jia J,Che L,Cigliano A,Wang X,Peitta G,Tao J,Zhong S,Ribback S,Evert M,Chen X,Calvisi DF

    更新日期：2020-11-11 00:00:00

  • Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.

    abstract：:GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golg...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010085

    authors： Sanwald JL,Dobner J,Simons IM,Poschmann G,Stühler K,Üffing A,Hoffmann S,Willbold D

    更新日期：2020-12-23 00:00:00

  • Overexpression of the Auxin Receptor AFB3 in Arabidopsis Results in Salt Stress Resistance and the Modulation of NAC4 and SZF1.

    abstract：:Soil salinity is a key problem for crop production worldwide. High salt concentration in soil negatively modulates plant growth and development. In roots, salinity affects the growth and development of both primary and lateral roots. The phytohormone auxin regulates various developmental processes during the plant's l...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249528

    authors： Garrido-Vargas F,Godoy T,Tejos R,O'Brien JA

    更新日期：2020-12-15 00:00:00

  • Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy.

    abstract：:MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the poss...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22031105

    authors： Del Pozo-Acebo L,Hazas MLL,Tomé-Carneiro J,Gil-Cabrerizo P,San-Cristobal R,Busto R,García-Ruiz A,Dávalos A

    更新日期：2021-01-22 00:00:00

  • Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts.

    abstract：:Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mech...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113744

    authors： Szabó MR,Gáspár R,Pipicz M,Zsindely N,Diószegi P,Sárközy M,Bodai L,Csont T

    更新日期：2020-05-26 00:00:00

  • Escherichia coli Extract-Based Cell-Free Expression System as an Alternative for Difficult-to-Obtain Protein Biosynthesis.

    abstract：:Before utilization in biomedical diagnosis, therapeutic treatment, and biotechnology, the diverse variety of peptides and proteins must be preliminarily purified and thoroughly characterized. The recombinant DNA technology and heterologous protein expression have helped simplify the isolation of targeted polypeptides ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21030928

    authors： Smolskaya S,Logashina YA,Andreev YA

    更新日期：2020-01-31 00:00:00

  • Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines.

    abstract：:Therapeutic efficacy of cisplatin-based chemotherapy for advanced-stage urothelial carcinoma (UC) is limited by drug resistance. The nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway is a major regulator of cytoprotective responses. We investigated its involvement in cisplatin resistance in long-term cisplati...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18081680

    authors： Skowron MA,Niegisch G,Albrecht P,van Koeveringe G,Romano A,Albers P,Schulz WA,Hoffmann MJ

    更新日期：2017-08-02 00:00:00

  • Adult Renal Stem/Progenitor Cells Can Modulate T Regulatory Cells and Double Negative T Cells.

    abstract：:Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulation...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010274

    authors： Curci C,Picerno A,Chaoul N,Stasi A,De Palma G,Franzin R,Pontrelli P,Castellano G,Pertosa GB,Macchia L,Di Lorenzo VF,Sabbà C,Gallone A,Gesualdo L,Sallustio F

    更新日期：2020-12-29 00:00:00

  • The Chitosan/Agarose/NanoHA Bone Scaffold-Induced M2 Macrophage Polarization and Its Effect on Osteogenic Differentiation In Vitro.

    abstract：:Chronic immune response to bone implant may lead to delayed healing and its failure. Thus, newly developed biomaterials should be characterized by high biocompatibility. Moreover, it is well known that macrophages play a crucial role in the controlling of biomaterial-induced inflammatory response. Immune cells synthes...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22031109

    authors： Kazimierczak P,Koziol M,Przekora A

    更新日期：2021-01-23 00:00:00