Abstract:
:Prostate cancer (PrCa) ranks among the top five cancers for both incidence and mortality worldwide. A significant proportion of PrCa susceptibility has been attributed to inherited predisposition, with 10-20% of cases expected to occur in a hereditary/familial context. Advances in DNA sequencing technologies have uncovered several moderate- to high-penetrance PrCa susceptibility genes, most of which have previously been related to known hereditary cancer syndromes, namely the hereditary breast and ovarian cancer (BRCA1, BRCA2, ATM,CHEK2, and PALB2) and Lynch syndrome (MLH1, MSH2, MSH6, and PMS2) genes. Additional candidate genes have also been suggested, but further evidence is needed to include them in routine genetic testing. Recommendations based on clinical features, family history, and ethnicity have been established for more cost-efficient genetic testing of patients and families who may be at an increased risk of developing PrCa. The identification of alterations in PrCa predisposing genes may help to inform screening strategies, as well as treatment options, in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PrCa, the current genetic screening recommendations, and the implications for clinical management of the disease.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Brandão A,Paulo P,Teixeira MRdoi
10.3390/ijms21145036subject
Has Abstractpub_date
2020-07-16 00:00:00issue
14issn
1422-0067pii
ijms21145036journal_volume
21pub_type
杂志文章,评审abstract::Sunflower (Helianthus annuus L.) oil remains under-utilised albeit one of the major seed oils produced world-wide. Moreover, the high oleic sunflower varieties make the oil attractive for applications requiring high temperature processes and those targeting the C=C double bond functionality. Herein an overview of the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9081393
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020829
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113301
更新日期:2018-10-24 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17060946
更新日期:2016-06-15 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms161025865
更新日期:2015-10-28 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21031090
更新日期:2020-02-06 00:00:00
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journal_title:International journal of molecular sciences
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pub_type: 杂志文章
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2016-05-26 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2018-02-08 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms15023145
更新日期:2014-02-21 00:00:00
abstract::Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projec...
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pub_type: 面试
doi:10.3390/ijms17071038
更新日期:2016-07-05 00:00:00