Abstract：
:The authors wish to make the following corrections to this paper [...].
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Elbadawy M,Usui T,Yamawaki H,Sasaki Kdoi
10.3390/ijms21124560subject
Has Abstractpub_date
2020-06-26 00:00:00issue
12issn
1422-0067pii
ijms21124560journal_volume
21pub_type
杂志文章,已发布勘误abstract：:Patients with advanced skeletal metastases arising from primary cancers including breast, lung, and prostate suffer from extreme pain, bone loss, and frequent fractures. While the importance of interactions between bone and tumors is well-established, our understanding of complex cell-cell and cell-microenvironment in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186913
更新日期：2020-09-21 00:00:00
abstract：:The activation of extracellular signal-regulated kinases (ERK) leads to a number of cellular changes associated with the development of long-term memory. Using cultured cortical neurons, we previously showed that the n-hexane extract prepared from the peels of Citrus grandis (Kawachi bankan) induces the activation of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13055338
更新日期：2012-01-01 00:00:00
abstract：:The composition of IL-23R complex is similar to that of the IL-12 receptor (IL-12R) complex with a shared IL-12R-β1 chain. The IL-12R-β1 heterodimerizes with IL-23R and IL-12R-β2 to form IL-23R and IL-12R complexes, respectively. The IL-12R-β2 has been shown to function as a tumor suppressor gene and apoptotic inducer...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141224656
更新日期：2013-12-18 00:00:00
abstract：:Persistent cell shrinkage, called apoptotic volume decrease (AVD), is a pivotal event of apoptosis. Activation of the volume-sensitive outwardly rectifying Cl(-) channel (VSOR) is involved in the AVD induction. On the other hand, activation of the MAP kinase (MAPK) cascade is also known to play a critical role in apop...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13079363
更新日期：2012-01-01 00:00:00
abstract：:The interactions of plants with environment and insects are bi-directional and dynamic. Consequently, a myriad of mechanisms has evolved to engage organisms in different types of interactions. These interactions can be mediated by allelochemicals known as volatile organic compounds (VOCs) which include volatile terpen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197382
更新日期：2020-10-06 00:00:00
abstract：:Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient's quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP's) which have demonstrated the ab...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228480
更新日期：2020-11-11 00:00:00
abstract：:Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme from ATP to inorganic polyphosphate (poly-P); a directed evolution program has been initiated. In ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126073
更新日期：2015-11-24 00:00:00
abstract：:Adverse experiences and chronic stress are well-known risk factors for the development of major depression, and an impaired stress response regulation is frequently observed in acute depression. Impaired glucocorticoid receptor (GR) signalling plays an important role in these alterations, and a restoration of GR signa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030485
更新日期：2019-01-23 00:00:00
abstract：:The treatment of metastatic breast cancer remained a challenge despite the recent breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional immunophenotyping of 4T1 metastatic breast cancer by the state-of-the-art single cell mass cytometry (CyTOF). We determined the dose and time dependent c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010170
更新日期：2019-12-25 00:00:00
abstract：:The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155559
更新日期：2020-08-03 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and thus better understanding of its molecular pathology is crucial for us to devise more effective treatment of this deadly disease. As cancer cell line remains a convenient starting point for discovery and proof-of-concept studies, here ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184473
更新日期：2019-09-10 00:00:00
abstract：:The purpose of the study was to investigate the antioxidant characteristics of Anisomeles indica methanol extract and the inhibitory effect of ovatodiolide on melanogenesis. In the study, the antioxidant capacities of A. indica methanol extract such as DPPH assay, ABTS radical scavenging assay, reducing capacity and m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056220
更新日期：2012-01-01 00:00:00
abstract：:The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071576
更新日期：2019-03-29 00:00:00
abstract：:Many microbial ecology studies have demonstrated profound changes in community composition caused by environmental pollution, as well as adaptation processes allowing survival of microbes in polluted ecosystems. Soil microbial communities in polluted areas with a long-term history of contamination have been shown to m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060933
更新日期：2016-06-14 00:00:00
abstract：:donor⁻acceptorDonor⁻acceptor⁻π⁻acceptor⁻donor (D1-A1-π-A2/A3-D2)-type small molecules, such TPA-MC-2 and TPA-MC-3, were designed and synthesized starting from donor-substituted alkynes (TPA-MC-1) via [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimeth...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071621
更新日期：2019-04-01 00:00:00
abstract：:Gene knock-in techniques have rapidly evolved in recent years, along with the development and maturation of genome editing technology using programmable nucleases. We recently reported a novel strategy for microhomology-mediated end-joining-dependent integration of donor DNA by using TALEN or CRISPR/Cas9 and optimized...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161023849
更新日期：2015-10-09 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) is a major cause of death and disability in neonates. HI leads to a dramatic rise in intracellular calcium levels, which was originally thought to be detrimental to the brain. However, it has been increasingly recognized that this calcium signaling may also play an important protective r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092063
更新日期：2019-04-26 00:00:00
abstract：:Purple-leaf tea is a phenotype with unique color because of its high anthocyanin content. The special flavor of purple-leaf tea is highly different from that of green-leaf tea, and its main ingredient is also of economic value. To probe the genetic mechanism of the phenotypic characteristics of tea leaf color, we cond...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114167
更新日期：2020-06-11 00:00:00
abstract：:The circadian system is an endogenous timekeeping system that synchronizes physiology and behavior with the 24 h solar day. Mice with total deletion of the core circadian clock gene Bmal1 show circadian arrhythmicity, cognitive deficits, and accelerated age-dependent decline in adult neurogenesis as a consequence of i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041394
更新日期：2020-02-19 00:00:00
abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12063998
更新日期：2011-01-01 00:00:00
abstract：:(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western bl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13032717
更新日期：2012-01-01 00:00:00
abstract：:The olfactory system, composed of the olfactory organs and the olfactory bulb, allows organisms to interact with their environment and through the detection of odor signals. Olfaction mediates behaviors pivotal for survival, such as feeding, mating, social behavior, and danger assessment. The olfactory organs are dire...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071639
更新日期：2019-04-02 00:00:00
abstract：:Fertility preservation for prepubertal boys relies exclusively on cryopreservation of immature testicular tissue (ITT) containing spermatogonia as the only cells with reproductive potential. Preclinical studies that used a nude mice model to evaluate the development of human transplanted ITT were characterized by impo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235833
更新日期：2019-11-20 00:00:00
abstract：:Wushanicaritin, a natural polyphenol compound, exerts many biological activities. This study aimed to characterize wushanicaritin glucuronidation by pooled human liver microsomes (HLM), human intestine microsomes and individual uridine diphosphate-glucuronosyltransferase (UGT) enzyme. Glucuronidation rates were determ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18091983
更新日期：2017-09-19 00:00:00
abstract：:The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217899
更新日期：2020-10-24 00:00:00
abstract：:Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020916
更新日期：2021-01-18 00:00:00
abstract：:Acute kidney injury (AKI) is a fatal medical episode caused by sudden kidney damage or failure, leading to the death of patients within a few hours or days. Previous studies demonstrated that exosomes derived from various mesenchymal stem/stromal cells (MSC-exosomes) have positive effects on renal injuries in multiple...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134774
更新日期：2020-07-05 00:00:00
abstract：:Due to the addressability and programmability, DNA has been applied not merely in constructing static elegant nanostructures such as two dimensional and three dimensional DNA nanostructures but also in designing dynamic nanodevices. Moreover, DNA could combine with hydrophobic organic molecules to be a new amphiphilic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082283
更新日期：2018-08-03 00:00:00
abstract：:Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194667
更新日期：2019-09-20 00:00:00
abstract：:The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid me...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225735
更新日期：2019-11-15 00:00:00
