Comparison of Metabolome and Transcriptome of Flavonoid Biosynthesis Pathway in a Purple-Leaf Tea Germplasm Jinmingzao and a Green-Leaf Tea Germplasm Huangdan reveals Their Relationship with Genetic Mechanisms of Color Formation.

Abstract:

:Purple-leaf tea is a phenotype with unique color because of its high anthocyanin content. The special flavor of purple-leaf tea is highly different from that of green-leaf tea, and its main ingredient is also of economic value. To probe the genetic mechanism of the phenotypic characteristics of tea leaf color, we conducted widely targeted metabolic and transcriptomic profiling. The metabolites in the flavonoid biosynthetic pathway of purple- and green-leaf tea were compared, and results showed that phenolic compounds, including phenolic acids, flavonoids, and tannins, accumulated in purple-leaf tea. The high expression of genes related to flavonoid biosynthesis (e.g., PAL and LAR) exhibits the specific expression of biosynthesis and the accumulation of these metabolites. Our result also shows that two CsUFGTs were positively related to the accumulation of anthocyanin. Moreover, genes encoding transcription factors that regulate flavonoids were identified by coexpression analysis. These results may help to identify the metabolic factors that influence leaf color differentiation and provide reference for future research on leaf color biology and the genetic improvement of tea.

journal_name

Int J Mol Sci

authors

Chen X,Wang P,Zheng Y,Gu M,Lin X,Wang S,Jin S,Ye N

doi

10.3390/ijms21114167

subject

Has Abstract

pub_date

2020-06-11 00:00:00

issue

11

issn

1422-0067

pii

ijms21114167

journal_volume

21

pub_type

杂志文章
  • Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.

    abstract::Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs). Understanding central nervous system (CNS) pathophysiology in neuronopathic MPS II (nMPS II) has been hi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21155188

    authors: Bhalla A,Ravi R,Fang M,Arguello A,Davis SS,Chiu CL,Blumenfeld JR,Nguyen HN,Earr TK,Wang J,Astarita G,Zhu Y,Fiore D,Scearce-Levie K,Diaz D,Cahan H,Troyer MD,Harris JM,Escolar ML

    更新日期:2020-07-22 00:00:00

  • The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective.

    abstract::Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix upon exposure to met...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21030980

    authors: Hou YC,Lu CL,Yuan TH,Liao MT,Chao CT,Lu KC

    更新日期:2020-02-01 00:00:00

  • Dysbindin-1 Involvement in the Etiology of Schizophrenia.

    abstract::Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success on cognitive impairment and long-term disability and are burdened by side effects. Although new antipsyc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18102044

    authors: Wang H,Xu J,Lazarovici P,Zheng W

    更新日期:2017-09-22 00:00:00

  • Thermal Aging Rheological Behavior of Magnetorheological Elastomers Based on Silicone Rubber.

    abstract::Engineering rubber composites have been widely used as main components in many fields including vehicle engineering and biomedical applications. However, when a rubber composite surface area is exposed to heat or sunlight and over a long-term accelerated exposure and lifecycle of test, the rubber becomes hard, thus in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21239007

    authors: Aziz SAA,Mazlan SA,Ubaidillah U,Mohamad N,Choi SB,Che Aziz MA,Johari MAF,Homma K

    更新日期:2020-11-27 00:00:00

  • Influence of Cationic meso-Substituted Porphyrins on the Antimicrobial Photodynamic Efficacy and Cell Membrane Interaction in Escherichia coli.

    abstract::Photodynamic inactivation (PDI) is a non-antibiotic option for the treatment of infectious diseases. Although Gram-positive bacteria have been shown to be highly susceptible to PDI, the inactivation of Gram-negative bacteria has been more challenging due to the impermeability properties of the outer membrane. In the p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20010134

    authors: Hurst AN,Scarbrough B,Saleh R,Hovey J,Ari F,Goyal S,Chi RJ,Troutman JM,Vivero-Escoto JL

    更新日期:2019-01-01 00:00:00

  • Plant regeneration and somatic embryogenesis from immature embryos derived through interspecific hybridization among different Carica species.

    abstract::Plant regeneration and somatic embryogenesis through interspecific hybridization among different Carica species were studied for the development of a papaya ringspot virus-resistant variety. The maximum fruit sets were recorded from the cross of the native variety C. papaya cv. Shahi with the wild species C. cauliflor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms131217065

    authors: Azad MA,Rabbani MG,Amin L

    更新日期:2012-12-12 00:00:00

  • Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis.

    abstract::Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20030585

    authors: Schröder A,Nazet U,Muschter D,Grässel S,Proff P,Kirschneck C

    更新日期:2019-01-30 00:00:00

  • Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes.

    abstract::(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: closure time of collagen-ADP (Col-ADP) and of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20133221

    authors: Pujol-Moix N,Martinez-Perez A,Sabater-Lleal M,Llobet D,Vilalta N,Hamsten A,Souto JC,Soria JM

    更新日期:2019-06-30 00:00:00

  • Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions.

    abstract::Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora o...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20174171

    authors: Shimada T,Yasuda S,Sugiura H,Yamagata K

    更新日期:2019-08-26 00:00:00

  • Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

    abstract::Therapeutic drug monitoring is routinely performed to maintain optimal tacrolimus concentrations in kidney transplant recipients. Nonetheless, toxicity and rejection still occur within an acceptable concentration-range. To have a better understanding of the relationship between tacrolimus dose, tacrolimus concentratio...

    journal_title:International journal of molecular sciences

    pub_type: 临床试验,杂志文章

    doi:10.3390/ijms20194710

    authors: In 't Veld AE,Grievink HW,Saghari M,Stuurman FE,de Kam ML,de Vries APJ,de Winter BCM,Burggraaf J,Cohen AF,Moerland M

    更新日期:2019-09-23 00:00:00

  • Advances in the function and regulation of hydrogenase in the cyanobacterium Synechocystis PCC6803.

    abstract::In order to use cyanobacteria for the biological production of hydrogen, it is important to thoroughly study the function and the regulation of the hydrogen-production machine in order to better understand its role in the global cell metabolism and identify bottlenecks limiting H2 production. Most of the recent advanc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms151119938

    authors: Cassier-Chauvat C,Veaudor T,Chauvat F

    更新日期:2014-10-31 00:00:00

  • Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) deposition and amyloid...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21155553

    authors: Son Y,Jeong YJ,Shin NR,Oh SJ,Nam KR,Choi HD,Choi JY,Lee HJ

    更新日期:2020-08-03 00:00:00

  • Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization.

    abstract::Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause cataracts in people and in mice. Studies in mouse models have begun to ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21165822

    authors: Berthoud VM,Gao J,Minogue PJ,Jara O,Mathias RT,Beyer EC

    更新日期:2020-08-13 00:00:00

  • Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.

    abstract::The coupling of alternative splicing with the nonsense-mediated decay (NMD) pathway maintains quality control of the transcriptome in eukaryotes by eliminating transcripts with premature termination codons (PTC) and fine-tunes gene expression. Long noncoding RNA (lncRNA) can regulate multiple cellular processes, inclu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165605

    authors: Fefilova A,Melnikov P,Prikazchikova T,Abakumova T,Kurochkin I,Mazin PV,Ziganshin R,Sergeeva O,Zatsepin TS

    更新日期:2020-08-05 00:00:00

  • Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.

    abstract::The current knowledge about neuroprotective mechanisms in humans after status epilepticus is scarce. One reason is the difficulty to measure possible mediators of these neuroprotective mechanisms. The dawn of microRNA detection in the cerebrospinal fluid (CSF) and the recent advancements in measuring proteins in the C...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18030490

    authors: Körtvelyessy P,Huchtemann T,Heinze HJ,Bittner DM

    更新日期:2017-02-24 00:00:00

  • Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease.

    abstract::The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18020251

    authors: Comes G,Manso Y,Escrig A,Fernandez-Gayol O,Sanchis P,Molinero A,Giralt M,Carrasco J,Hidalgo J

    更新日期:2017-01-26 00:00:00

  • Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.

    abstract::Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential to improve lung fibrosis and lung cancer. To avoid the liver and kidney toxicities and the fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared and their characteristics were studied. ED...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15046241

    authors: Chen X,Yang Z,Sun R,Mo Z,Jin G,Wei F,Hu J,Guan W,Zhong N

    更新日期:2014-04-11 00:00:00

  • Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor.

    abstract::The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dimerization, activatio...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17081200

    authors: Kourouniotis G,Wang Y,Pennock S,Chen X,Wang Z

    更新日期:2016-07-25 00:00:00

  • Remotely triggered scaffolds for controlled release of pharmaceuticals.

    abstract::Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great potential for future biomedical applications. Here we successfully fabri...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14048585

    authors: Roach P,McGarvey DJ,Lees MR,Hoskins C

    更新日期:2013-04-19 00:00:00

  • Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway.

    abstract::Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol is present in a variety of plants, including the skin of grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown to offer protective effects against a number of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20040998

    authors: Chuang YC,Chen SD,Hsu CY,Chen SF,Chen NC,Jou SB

    更新日期:2019-02-25 00:00:00

  • Animal Models of Pneumococcal pneumonia.

    abstract::Streptococcus pneumoniae remains the most common bacterial pathogen causing lower respiratory tract infections and is a leading cause of morbidity and mortality worldwide, especially in children and the elderly. Another important aspect related to pneumococcal infections is the persistent rate of penicillin and macrol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20174220

    authors: Borsa N,Pasquale MD,Restrepo MI

    更新日期:2019-08-28 00:00:00

  • Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1.

    abstract::In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environment affects placental development, which also includes the trophoblast ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21020468

    authors: Hoch D,Bachbauer M,Pöchlauer C,Algaba-Chueca F,Tandl V,Novakovic B,Megia A,Gauster M,Saffery R,Glasner A,Desoye G,Majali-Martinez A

    更新日期:2020-01-11 00:00:00

  • Small molecule membrane transporters in the mammalian podocyte: a pathogenic and therapeutic target.

    abstract::The intriguingly complex glomerular podocyte has been a recent object of intense study. Researchers have sought to understand its role in the pathogenesis of common proteinuric diseases such as minimal change disease and focal segmental glomerular sclerosis. In particular, considerable effort has been directed towards...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms151121366

    authors: Zennaro C,Artero M,Di Maso V,Carraro M

    更新日期:2014-11-18 00:00:00

  • A chitosan induced 9-lipoxygenase in Adelostemma gracillimum seedlings.

    abstract::Oxylipins generated by the lipoxygenase (LOX) pathway play an important role in plant defense against biotic and abiotic stress. In chitosan-treated Adelostemma gracillimum seedlings, obvious accumulation of 9-LOX-derived oxylipins, namely 9,10,11-trihydroxy-12-octadecenoic acid, was detected. Using degenerate primers...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13010540

    authors: Li J,Zhao PJ,Ma CL,Zeng Y

    更新日期:2012-01-01 00:00:00

  • Gene-Diet Interaction and Precision Nutrition in Obesity.

    abstract::The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18040787

    authors: Heianza Y,Qi L

    更新日期:2017-04-07 00:00:00

  • Targeting Age-Dependent Functional and Metabolic Decline of Human Skeletal Muscle: The Geroprotective Role of Exercise, Myokine IL-6, and Vitamin D.

    abstract::In the elderly, whole-body health largely relies on healthy skeletal muscle, which controls body stability, locomotion, and metabolic homeostasis. Age-related skeletal muscle structural/functional deterioration is associated with a higher risk of severe comorbid conditions and poorer outcomes, demanding major socioeco...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21031010

    authors: Crescioli C

    更新日期:2020-02-04 00:00:00

  • Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway.

    abstract::In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21155436

    authors: Wu PK,Becker A,Park JI

    更新日期:2020-07-30 00:00:00

  • Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes.

    abstract::Cadmium is a deleterious environmental pollutant that threats both animals and human health. Oxidative stress and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure. We investigate, here, the protective effect of strawber...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18050957

    authors: Elmallah MIY,Elkhadragy MF,Al-Olayan EM,Abdel Moneim AE

    更新日期:2017-05-05 00:00:00

  • Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models.

    abstract::Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is the leading cause of years lived with disability (YLD) worldwide. Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the elucidation of the mechanism underlying the pathogenesis of pai...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21020533

    authors: Hong JI,Park IY,Kim HA

    更新日期:2020-01-14 00:00:00

  • Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model.

    abstract::Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome and less DIND (delayed ischemic neurological deficits). In rat experiments, enhanced axonal sprouting and higher survival of motoneurons was demonstrated after cutting or crushing the fac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms151018453

    authors: Herzfeld E,Strauss C,Simmermacher S,Bork K,Horstkorte R,Dehghani F,Scheller C

    更新日期:2014-10-14 00:00:00