Abstract：
:In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different cell types. Growing evidence suggests that the cell fate toward these paradoxical physiological outputs may be determined not only at downstream effector levels but also at the pathway level, which involves the magnitude of pathway activity, spatial-temporal regulation, and non-canonical functions of the molecular switches in this pathway. This review discusses recent updates on the molecular mechanisms underlying the pathway-mediated growth inhibitory signaling, with a major focus on the regulation mediated at the pathway level.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wu PK,Becker A,Park JIdoi
10.3390/ijms21155436subject
Has Abstractpub_date
2020-07-30 00:00:00issue
15issn
1422-0067pii
ijms21155436journal_volume
21pub_type
杂志文章,评审abstract：:Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140918599
更新日期：2013-09-10 00:00:00
abstract：:Phototropin2 (phot2) is a blue-light (BL) receptor protein that regulates the BL-dependent activities of plants for efficient photosynthesis. Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain. Photo-activated LOV domains, especially LOV2, play a major role ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186638
更新日期：2020-09-10 00:00:00
abstract：:Poly-γ-glutamic acid (γ-PGA)-based nanoparticles draw remarkable attention as drug delivery agents due to their controlled release characteristics, low toxicity, and biocompatibility. 4HGF is an herbal mixture of Phellinus linteus grown on germinated brown rice, Cordyceps militaris grown on germinated soybeans, Polygo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143447
更新日期：2019-07-13 00:00:00
abstract：:Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion molecules. The primary AML cells express various integrins. These heterodimeric molecules containing an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010251
更新日期：2018-01-15 00:00:00
abstract：:Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased right ventricular (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092730
更新日期：2018-09-12 00:00:00
abstract：:Drought adversely affects crop production across the globe. The root system immensely contributes to water management and the adaptability of plants to drought stress. In this study, drought-induced phenotypic and transcriptomic responses of two contrasting chickpea (Cicer arietinum L.) genotypes were compared at the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051781
更新日期：2020-03-05 00:00:00
abstract：:A k-nearest neighbor (k-NN) classification model was constructed for 118 RDT NEDO (Repeated Dose Toxicity New Energy and industrial technology Development Organization; currently known as the Hazard Evaluation Support System (HESS)) database chemicals, employing two acute toxicity (LD50)-based classes as a response an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160511659
更新日期：2015-05-21 00:00:00
abstract：:Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194903
更新日期：2019-10-03 00:00:00
abstract：:Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21103723
更新日期：2020-05-25 00:00:00
abstract：:In the present study, we investigated the signal transduction of mutants of the eel follicle-stimulating hormone receptor (eelFSHR). Specifically, we examined the constitutively activating mutant D540G in the third intracellular loop, and four inactivating mutants (A193V, N195I, R546C, and A548V). To directly assess f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197075
更新日期：2020-09-25 00:00:00
abstract：:The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141123086
更新日期：2013-11-21 00:00:00
abstract：:Skeletal muscle comprising approximately 40% of body weight is highly important for locomotion and metabolic homeostasis. The growth and regeneration of skeletal muscle are highly organized processes; thus, it is not surprising to reveal certain complexity during these regulatory processes. Recently, a large number of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19020405
更新日期：2018-01-30 00:00:00
abstract：:Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This stu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010065
更新日期：2016-01-05 00:00:00
abstract：:Growing evidence shows a close association of transposable elements (TE) with non-coding RNAs (ncRNA), and a significant number of small ncRNAs originate from TEs. Further, ncRNAs linked with TE sequences participate in a wide-range of regulatory functions. Alu elements in particular are critical players in gene regul...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140713307
更新日期：2013-06-26 00:00:00
abstract：:Worldwide, women account for approximately 51% of human immunodeficiency virus-1 (HIV) seropositive individuals. The prevalence of neuropathic pain among individuals with HIV and a lack of preclinical data characterizing sex differences prompted us to address this knowledge gap. C57BL/6 male and female mice received m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051196
更新日期：2019-03-09 00:00:00
abstract：:The present study investigates the photochemical properties of potential photosensitizers for photodynamic therapy, namely four commercial heptamethinecyanine dyes (IR125, IR780, IR813, IR820). Spectroscopic studies were made by means of laser induced fluorescence and laser flash photolysis in order to obtain fluoresc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140918557
更新日期：2013-09-09 00:00:00
abstract：:The anaerobic digestion of filter cake and its co-digestion with bagasse, and the effect of gradual increase of the organic loading rate (OLR) from start-up to overload were investigated. Understanding the influence of environmental and technical parameters on the development of particular methanogenic pathway in the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161023210
更新日期：2015-09-25 00:00:00
abstract：:Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020339
更新日期：2017-02-06 00:00:00
abstract：:Binding affinity prediction of potential drugs to target and off-target proteins is an essential asset in drug development. These predictions require the calculation of binding free energies. In such calculations, it is a major challenge to properly account for both the dynamic nature of the protein and the possible v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010798
更新日期：2014-01-09 00:00:00
abstract：:Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located in the ependymal canal (epSPC). epSPC from non-injured ani...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161125981
更新日期：2015-11-06 00:00:00
abstract：:We herein review available computational and experimental data pointing to the abundance of structural disorder within the nucleoprotein (N) and phosphoprotein (P) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. We provide a detailed molecular description of the mechanisms g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160715688
更新日期：2015-07-10 00:00:00
abstract：:Recent studies suggested that sestrin2 is a crucial modulator for the production of reactive oxygen species (ROS). In addition, sestrin2 may also regulate ribosomal protein S6 (RpS6), a molecule important for protein synthesis, through the effect of mammalian target of rapamycin (mTOR) complex that is pivotal for long...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161125963
更新日期：2015-11-04 00:00:00
abstract：:Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally high with regard to physiological oxygen concentration (low micromolar). In this study using polarographic measurement of oxygen concentratio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239149
更新日期：2020-11-30 00:00:00
abstract：:Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific "signal transducer and activator of transcription" (STA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061591
更新日期：2018-05-28 00:00:00
abstract：:We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15058352
更新日期：2014-05-12 00:00:00
abstract：:Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are believed to be important for cardiovascular health. Many investigations have been carried out in an attempt to examine the effect of n-3 PUFAs intake, in the form of supplementation or fortified foods, for the management of cardiovascular disease (CVD) and risk facto...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071552
更新日期：2017-07-18 00:00:00
abstract：:The maturation of iPSC-derived cardiomyocytes is still a critical point for their application in cardiovascular research as well as for their clinical use. Although multiple differentiation protocols have been established, researchers failed to generate fully mature cardiomyocytes in vitro possessing identical phenoty...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082819
更新日期：2020-04-17 00:00:00
abstract：:In recent years, the overuse of antibiotics has become very serious. Many pathogenic bacteria have become resistant to them, with serious potential health consequences. Thus, it is urgent that we develop new antibiotic drugs. Antimicrobial peptides (AMPs) are important endogenous antibacterial molecules that contribut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19102951
更新日期：2018-09-27 00:00:00
abstract：:Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic-therapeutic strategy. Therefore, we developed a laboratory protocol, ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040893
更新日期：2019-02-19 00:00:00
abstract：:Citral is well known for its antimicrobial, antifungal, and insecticidal activities. Natural sesquiterpene α-methylenelactones also exhibit a broad spectrum of biological activities. The aim of the study was to explore the effect of structural changes to citral molecules on citral behavior-modifying activity towards M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218029
更新日期：2020-10-28 00:00:00
