Abstract：
:The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Heianza Y,Qi Ldoi
10.3390/ijms18040787subject
Has Abstractpub_date
2017-04-07 00:00:00issue
4issn
1422-0067pii
ijms18040787journal_volume
18pub_type
杂志文章,评审abstract：:In this study, the effect of the acetone extract of Arctotis arctotoides (L.f.) O. Hoffm. (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS was analyzed by means of scanning electron microscope (SEM). Remarkable morphological alterations in the fungal mycelia which were...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12129226
更新日期：2011-01-01 00:00:00
abstract：:Abstract: Heart failure (HF) is associated with skeletal muscle wasting and exercise intolerance. This study aimed to evaluate the exercise-induced clinical response and histological alterations. One hundred and forty-four HF patients were enrolled. The individual training program was determined as a workload at or cl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215514
更新日期：2019-11-05 00:00:00
abstract：:Early inhibition of inflammation suppresses the carcinogenic process. Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2). Multiple randomized clinical trials have demonstrated that aspirin offers substantial protection from ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010166
更新日期：2018-01-06 00:00:00
abstract：:The proteome of zygotic embryos of Acer platanoides L. was analyzed via high-resolution 2D-SDS-PAGE and MS/MS in order to: (1) identify significant physiological processes associated with embryo development; and (2) identify changes in the proteome of the embryo associated with the acquisition of seed dormancy. Sevent...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610868
更新日期：2014-06-17 00:00:00
abstract：:The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155224
更新日期：2020-07-23 00:00:00
abstract：:Biliverdin reductase A is an enzyme, with serine/threonine/tyrosine kinase activation, converting biliverdin (BV) to bilirubin (BR) in heme degradation pathway. It has been reported to have anti-inflammatory and antioxidant effect in monocytes and human glioblastoma. However, the function of BVRA in polarized macropha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160922621
更新日期：2015-09-18 00:00:00
abstract：:Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced ace...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133178
更新日期：2019-06-28 00:00:00
abstract：:Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. However, resistance to endocrine therapy leads to breast cancer relapse. The recent extension of adjuvant tamoxifen treatment up to 10 years actualizes the need for identifying biological markers that may be used to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms161024243
更新日期：2015-10-14 00:00:00
abstract：:The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010337
更新日期：2020-12-30 00:00:00
abstract：:An increase in intracellular Ca2+ concentration ([Ca2+]i) plays a key role in controlling endothelial functions; however, it is still unclear whether endothelial Ca2+ handling is altered by type 2 diabetes mellitus, which results in severe endothelial dysfunction. Herein, we analyzed for the first time the Ca2+ respon...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010250
更新日期：2019-12-30 00:00:00
abstract：:Ascorbate oxidase (AO) plays important roles in plant growth and development. Previously, we reported a cotton AO gene that acts as a positive factor in cell growth. Investigations on Gossypium hirsutum AO (GhAO) family genes and their multiple functions are limited. The present study identified eight GhAO family gene...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246167
更新日期：2019-12-06 00:00:00
abstract：:Intestinal barrier function is required for the maintenance of mucosal homeostasis. Barrier dysfunction is thought to promote progression of both intestinal and systemic diseases. In many cases, this barrier loss reflects increased permeability of the paracellular tight junction as a consequence of myosin light chain ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030993
更新日期：2020-02-03 00:00:00
abstract：:Carbamazepine (CBZ) binds adenosine receptors, but detailed effects of CBZ on astroglial transmission associated with adenosine receptor still need to be clarified. To clarify adenosinergic action of CBZ on astroglial transmission, primary cultured astrocytes were acutely or chronically treated with CBZ, proinflammato...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153727
更新日期：2019-07-30 00:00:00
abstract：:Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause cataracts in people and in mice. Studies in mouse models have begun to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21165822
更新日期：2020-08-13 00:00:00
abstract：:Ovarian granulosa cells (GCs) are a critical approach to investigate the mechanism of gene regulation during folliculogenesis. The objective of this study was to investigate the role of MT2 in bovine GCs, and assess whether MT2 silencing affected GCs response to melatonin. We found that MT2 silencing significantly dec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072028
更新日期：2018-07-12 00:00:00
abstract：:The evaluation of antioxidant compounds that counteract the mutagenic effects caused by the direct action of reactive oxygen species on DNA molecule is of considerable interest. Therefore, a series of 2,3-substituted quinazolinone derivatives (Q1-Q8) were investigated by different assays, and the relationship between ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020610
更新日期：2021-01-09 00:00:00
abstract：:Intravenous administration of high-dose ascorbic acid (AA) has been reported as a treatment for cancer patients. However, cancer patients with renal failure cannot receive this therapy because high-dose AA infusion can have side effects. To solve this problem, we evaluated the antitumor activity of a lipophilic stable...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020535
更新日期：2018-02-10 00:00:00
abstract：:Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610334
更新日期：2014-06-10 00:00:00
abstract：:The ubiquitous second messenger 3',5'-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030801
更新日期：2018-03-10 00:00:00
abstract：:Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140816386
更新日期：2013-08-07 00:00:00
abstract：:The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cancer cell death with minimal damage to normal cells; however, some cancer cells are resistant to TRAIL. TRAIL resistance may be overcome by agonistic antibodies to TRAIL receptors. In this study, we report the toxic effects of a novel recomb...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20081967
更新日期：2019-04-22 00:00:00
abstract：:Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141121727
更新日期：2013-11-01 00:00:00
abstract：:Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation. This study was performed to screen potential biomarkers related to the occurrence, development and prognosis of LUSC to reveal unknown physiolog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082994
更新日期：2020-04-23 00:00:00
abstract：:A new approach for encoding DNA sequences as input for DNA sequence analysis is proposed using the error correction coding theory of communication engineering. The encoder was designed as a convolutional code model whose generator matrix is designed based on the degeneracy of codons, with a codon treated in the model ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14048393
更新日期：2013-04-16 00:00:00
abstract：:T cells are essential mediators of the adaptive immune system, which constantly patrol the body in search for invading pathogens. During an infection, T cells that recognise the pathogen are recruited, expand and differentiate into subtypes tailored to the infection. In addition, they differentiate into subsets requir...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21082674
更新日期：2020-04-11 00:00:00
abstract：:Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal degeneration underlies the vision loss such as occurs with retinitis pigmentosa. Under these conditions, optogenetic the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020522
更新日期：2020-01-14 00:00:00
abstract：:Normal tissue toxicity is a dose-limiting factor in radiation therapy. Therefore, a detailed understanding of the normal tissue response to radiation is necessary to predict the risk of normal tissue toxicity and to development strategies for tissue protection. One component of normal tissue that is continuously expos...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072336
更新日期：2020-03-27 00:00:00
abstract：:Recently, neuromediators such as substance P (SP) have been found to be important factors in tendon homeostasis. Some studies have found SP to be the cause of inflammation and tendinopathy, whereas others have determined it to be a critical component of tendon healing. As demonstrated by these conflicting findings, th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228633
更新日期：2020-11-16 00:00:00
abstract：:Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of Aspidosperma pyrifolium in reducing carrageenan-indu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112248
更新日期：2017-11-11 00:00:00
abstract：:MTH1 (MutT homolog 1) or NUDT1 (Nudix Hydrolase 1), also known as oxidized purine nucleoside triphosphatase, has potential as a biomarker for monitoring cancer progression and quantifying target engagement for relevant therapies. In this study, we validate one MTH1 inhibitor TH287 as a PET MTH1 radiotracer. TH287 was ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228860
更新日期：2020-11-23 00:00:00
