Abstract:
:Molecular etiology of thyroid cancers has been widely studied, and several molecular alterations have been identified mainly associated with follicular and papillary histotypes. However, the molecular bases of the complex pathogenesis of thyroid carcinomas remain poorly understood. HOX genes regulate normal embryonic development, cell differentiation and other critical processes in eukaryotic cell life. Several studies have shown that HOX genes play a role in neoplastic transformation of several human tissues. In particular, the genes belonging to HOX paralogous group 13 seem to hold a relevant role in both tumor development and progression. We have identified a significant prognostic role of HOX D13 in pancreatic cancer and we have recently showed the strong and progressive over-expression of HOX C13 in melanoma metastases and deregulation of HOX B13 expression in bladder cancers. In this study we have investigated, by immunohistochemisty and quantitative Real Time PCR, the HOX paralogous group 13 genes/proteins expression in thyroid cancer evolution and progression, also evaluating its ability to discriminate between main histotypes. Our results showed an aberrant expression, both at gene and protein level, of all members belonging to paralogous group 13 (HOX A13, HOX B13, HOX C13 and HOX D13) in adenoma, papillary and follicular thyroid cancers samples. The data suggest a potential role of HOX paralogous group 13 genes in pathogenesis and differential diagnosis of thyroid cancers.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cantile M,Scognamiglio G,La Sala L,La Mantia E,Scaramuzza V,Valentino E,Tatangelo F,Losito S,Pezzullo L,Chiofalo MG,Fulciniti F,Franco R,Botti Gdoi
10.3390/ijms141121727subject
Has Abstractpub_date
2013-11-01 00:00:00pages
21727-40issue
11issn
1422-0067pii
ijms141121727journal_volume
14pub_type
杂志文章abstract::The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms14059963
更新日期:2013-05-10 00:00:00
abstract::Parkinson's disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic component of PD. In particular, recent large-scale projects such as gen...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197332
更新日期:2020-10-04 00:00:00
abstract::Plant phenolics have shown to activate apoptotic cell death in different tumourigenic cell lines. In this study, we evaluated the effects of juniper berry extract (Juniperus communis L.) on p53 protein, gene expression and DNA fragmentation in human neuroblastoma SH-SY5Y cells. In addition, we analyzed the phenolic co...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17071113
更新日期:2016-07-13 00:00:00
abstract::Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treatin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176231
更新日期:2020-08-28 00:00:00
abstract::There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors. In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20102466
更新日期:2019-05-18 00:00:00
abstract::Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signatures of liver fibrosis in mouse models with malfunction in genes from un...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020832
更新日期:2021-01-15 00:00:00
abstract::Zebrafish is a well-recognized organism for investigating vertebrate development and human diseases. However, the data on zebrafish proteome are scarce, particularly during embryogenesis. This is mostly due to the overwhelming abundance of egg yolk proteins, which tend to mask the detectable presence of less abundant ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246359
更新日期:2019-12-17 00:00:00
abstract::Ovarian follicle steroidogenesis associated with embryo quality results in a successful pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete several steroid and peptide hormones. Follicles harvested from women who conceived after assisted reproductive therapy (ART) had significan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21103592
更新日期:2020-05-19 00:00:00
abstract::The expression of leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) has been reported in Parkinson's disease; however, its role in other diseases is unknown. Gastric cancer is the second leading cause of cancer death. Cancer stem cells (CSC) are a subpopulation ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030555
更新日期:2019-01-28 00:00:00
abstract::The largest group of deubiquitinases-ubiquitin-specific proteases (UBPs)-perform extensive and significant roles in plants, including the regulation of development and stress responses. A comprehensive analysis of UBP genes has been performed in Arabidopsis thaliana, but no systematic study has been conducted in moso ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174309
更新日期:2019-09-03 00:00:00
abstract::Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249688
更新日期:2020-12-18 00:00:00
abstract::Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn's disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093379
更新日期:2020-05-11 00:00:00
abstract::DNA G-quadruplexes (G4s) form in relevant genomic regions and intervene in several biological processes, including the modulation of oncogenes expression, and are potential anticancer drug targets. The human KRAS proto-oncogene promoter region contains guanine-rich sequences able to fold into G4 structures. Here, by u...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010448
更新日期:2021-01-05 00:00:00
abstract::Mucin1 (MUC1) is a highly glycosylated transmembrane protein that plays a crucial role in the lubrication and protection of normal epithelial cells. However, MUC1 has emerged as a potential target for cancer therapy because it is overexpressed and functions in several types of cancers. Recently, we produced a monoclon...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19072004
更新日期:2018-07-09 00:00:00
abstract::Confinement and crowding have been shown to affect protein fates, including folding, functional stability, and their interactions with self and other proteins. Using both theoretical and experimental studies, researchers have established the independent effects of confinement or crowding, but only a few studies have e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228516
更新日期:2020-11-12 00:00:00
abstract::Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18051054
更新日期:2017-05-13 00:00:00
abstract::To explain the cholesterol-reducing effects of dietary fibres, one of the major mechanisms proposed is the reduced reabsorption of bile acids in the ileum. The interaction of dietary fibres with bile acids is associated with their viscous or adsorptive effects. Since these fibre characteristics are difficult to invest...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082193
更新日期:2018-07-27 00:00:00
abstract::Ventricular arrhythmia (VA) is a major component of sudden cardiac death (SCD). To investigate the expression of brain natriuretic peptide (BNP), endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-β1) during VA, we established a rat model of VA induced by BaCl2 solution through a microinjector pump. PD142...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20235845
更新日期:2019-11-21 00:00:00
abstract::For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197104
更新日期:2020-09-26 00:00:00
abstract::Programmed cell death, such as apoptosis and autophagy, are key processes that are activated early on during development, leading to remodelling in embryos and homeostasis in adult organisms. Genomic conservation of death factors has been largely investigated in the animal and plant kingdoms. In this study, we analyse...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155201
更新日期:2020-07-22 00:00:00
abstract::Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investiga...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140611816
更新日期:2013-06-03 00:00:00
abstract::Osteochondrosis is a failure of the endochondral ossification that affects developing joints in humans and several animal species. It is a localized idiopathic joint disorder characterized by focal chondronecrosis and growing cartilage retention, which can lead to the formation of fissures, subchondral bone cysts, or ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246179
更新日期:2019-12-07 00:00:00
abstract::Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear. Here, we derived e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21165743
更新日期:2020-08-11 00:00:00
abstract::Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epitheli...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20143513
更新日期:2019-07-17 00:00:00
abstract::The interaction between programmed cell death protein (PD-1) and its ligand (PD-L1) is one of the main pathways used by some tumors to escape the immune response. In recent years, immunotherapies based on the use of antibodies against PD-1/PD-L1 have been postulated as a great promise for cancer treatment, increasing ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20092296
更新日期:2019-05-09 00:00:00
abstract::MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the prolif...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131216053
更新日期:2012-11-28 00:00:00
abstract::Multinucleated osteoclasts differentiate from hematopoietic progenitors of the monocyte/macrophage lineage. Because of its pivotal role in bone resorption, regulation of osteoclast differentiation is a potential therapeutic approach to the treatment of erosive bone disease. In this study, we have found that fucoidan, ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151018840
更新日期:2014-10-20 00:00:00
abstract::Overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. High-mobility group box 1 (HMGB1) plays important roles in the regulation of cellular death. Suppression of HMGB1 inhibits autophagy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174134
更新日期:2019-08-24 00:00:00
abstract::Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resident progenitor cells (CPC)-derived Exo reduced scarring and improved...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030468
更新日期:2019-01-22 00:00:00
abstract::Agonistic antibodies, which bind specifically to death receptor 5 (DR5), can trigger apoptosis in tumor cells through the extrinsic pathway. In this present study, we describe the use of a phage display to isolate a novel fully human agonistic single chain fragment variable (scFv) antibody, which targets DR5. After fi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18102064
更新日期:2017-09-27 00:00:00