Abstract：
:The olfactory system, composed of the olfactory organs and the olfactory bulb, allows organisms to interact with their environment and through the detection of odor signals. Olfaction mediates behaviors pivotal for survival, such as feeding, mating, social behavior, and danger assessment. The olfactory organs are directly exposed to the milieu, and thus are particularly vulnerable to damage by environmental pollutants and toxicants, such as heavy metals, pesticides, and surfactants, among others. Given the widespread occurrence of olfactory toxicants, there is a pressing need to understand the effects of these harmful compounds on olfactory function. Zebrafish (Danio rerio) is a valuable model for studying human physiology, disease, and toxicity. Additionally, the anatomical components of the zebrafish olfactory system are similar to those of other vertebrates, and they present a remarkable degree of regeneration and neuroplasticity, making it an ideal model for the study of regeneration, reorganization and repair mechanisms following olfactory toxicant exposure. In this review, we focus on (1) the anatomical, morphological, and functional organization of the olfactory system of zebrafish; (2) the adverse effects of olfactory toxicants and injury to the olfactory organ; and (3) remodeling and repair neuroplasticity mechanisms following injury and degeneration by olfactory toxicant exposure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Calvo-Ochoa E,Byrd-Jacobs CAdoi
10.3390/ijms20071639subject
Has Abstractpub_date
2019-04-02 00:00:00issue
7issn
1422-0067pii
ijms20071639journal_volume
20pub_type
杂志文章,评审abstract：:Heart failure (HF) is a rapidly growing global public health problem. Since HF results in high mortality and re-hospitalization, new effective treatments are desired. Although it remains controversial, omega 3 polyunsaturated fatty acids (n-3 PUFAs), such as the eicosapentaenoic acid and docosahexaenoic acid, have bee...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-08-18 00:00:00
abstract：:Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like...
journal_title：International journal of molecular sciences
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更新日期：2015-10-23 00:00:00
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更新日期：2020-09-26 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-04-22 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2021-01-09 00:00:00
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更新日期：2016-09-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2008-11-01 00:00:00
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更新日期：2019-07-31 00:00:00
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更新日期：2019-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-04-01 00:00:00
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更新日期：2019-03-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21041392
更新日期：2020-02-19 00:00:00
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doi：10.3390/ijms151223909
更新日期：2014-12-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms161226106
更新日期：2015-11-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140918999
更新日期：2013-09-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113407
更新日期：2018-10-31 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms21165909
更新日期：2020-08-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-03-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-10-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010377
更新日期：2013-12-31 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-02-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-06-16 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-07-19 00:00:00
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更新日期：2013-11-18 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms17060856
更新日期：2016-06-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-02-04 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms17050760
更新日期：2016-05-18 00:00:00
abstract：:The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective of this study was to evaluate how osmolarity influences human OA chond...
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doi：10.3390/ijms21020531
更新日期：2020-01-14 00:00:00
