Abstract：
:Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient's quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP's) which have demonstrated the ability to selectively target cancer cells in cellular and animal models. However, the major hurdle of clinical validation remains. NHP's warrant further clinical investigation as a therapeutic option since they exhibit low toxicity, while retaining a selective effect. Additionally, they can sensitize cancerous cells to chemotherapy, which enhances the efficacy of chemotherapeutic drugs, indicating that they can be utilized as supplemental therapy. An additional area for further research is the investigation of drug-drug interactions between NHP's and chemotherapeutics. The objectives of this review are to report the most recent results from the field of anticancer NHP research, and to highlight the most recent advancements in possible supplemental therapeutic options.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Scaria B,Sood S,Raad C,Khanafer J,Jayachandiran R,Pupulin A,Grewal S,Okoko M,Arora M,Miles L,Pandey Sdoi
10.3390/ijms21228480subject
Has Abstractpub_date
2020-11-11 00:00:00issue
22issn
1422-0067pii
ijms21228480journal_volume
21pub_type
杂志文章,评审abstract：:Metastatic castration-resistant prostate cancer is commonly treated with chemotherapy, whose effect is less than satisfactory. This raised the need for novel agents for the treatment of prostate cancer. In the present study, five phthalimide-based curcumin derivatives were synthesized and completely characterized to a...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-08-20 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms131013414
更新日期：2012-10-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-06-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-11-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-07-06 00:00:00
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