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Neurotrophic effect of citrus auraptene: neuritogenic activity in PC12 cells.

Abstract：

:The activation of extracellular signal-regulated kinases (ERK) leads to a number of cellular changes associated with the development of long-term memory. Using cultured cortical neurons, we previously showed that the n-hexane extract prepared from the peels of Citrus grandis (Kawachi bankan) induces the activation of ERK1/2 and that one of the compounds with this ability in the extract is 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), a Citrus polymethoxyflavone. In fact, we found that HMF has the ability to rescue mice from drug-induced learning impairment. This hexane extract contains auraptene (AUR), a coumarin derivative with a monoterpene unit, together with HMF. The present study was designed to investigate the effect of AUR in vitro. Our results show that 1) AUR had the ability to induce the activation of ERK1/2 in not only cortical neurons but also the rat pheochromocytoma cell line (PC12 cells), which is a model system for studies on neuronal proliferation and differentiation; and 2) AUR had the ability to promote neurite outgrowth from PC12 cells.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Furukawa Y,Watanabe S,Okuyama S,Nakajima M

doi

10.3390/ijms13055338

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

5338-47

issue

5

issn

1422-0067

pii

ijms-13-05338

journal_volume

13

pub_type

杂志文章

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