当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors.

The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors.

Abstract：

:This review highlights the added value of PET imaging in Central Nervous System (CNS) tumors, which is a tool that has rapidly evolved from a merely diagnostic setting to multimodal molecular diagnostics and the guidance of targeted therapy. PET is the method of choice for studying target expression and target binding behind the assumedly intact blood-brain barrier. Today, a variety of diagnostic PET tracers can be used for the primary staging of CNS tumors and to determine the effect of therapy. Additionally, theranostic PET tracers are increasingly used in the context of pharmaceutical and radiopharmaceutical drug development and application. In this approach, a single targeted drug is used for PET diagnosis, upon the coupling of a PET radionuclide, as well as for targeted (nuclide) therapy. Theranostic PET tracers have the potential to serve as a non-invasive whole body navigator in the selection of the most effective drug candidates and their most optimal dose and administration route, together with the potential to serve as a predictive biomarker in the selection of patients who are most likely to benefit from treatment. PET imaging supports the transition from trial and error medicine to predictive, preventive, and personalized medicine, hopefully leading to improved quality of life for patients and more cost-effective care.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Pruis IJ,van Dongen GAMS,Veldhuijzen van Zanten SEM

doi

10.3390/ijms21031029

subject

Has Abstract

pub_date

2020-02-04 00:00:00

issue

3

issn

1422-0067

pii

ijms21031029

journal_volume

21

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

    abstract：:Hepatocyte growth factor (HGF) is an endogenously expressed bioactive substance that has a strong anti-apoptotic effect. In this study, we biochemically and histologically characterized the effects of rh-HGF on in vitro human hepatocyte injury and mouse acute liver failure (ALF) models, both of which were induced by a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20081821

    authors： Motoi S,Toyoda H,Obara T,Ohta E,Arita Y,Negishi K,Moriya K,Kuboi Y,Soejima M,Imai T,Ido A,Tsubouchi H,Kawano T

    更新日期：2019-04-12 00:00:00

  • TNF-α gene knockout in triple negative breast cancer cell line induces apoptosis.

    abstract：:Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there is significant interest in understanding the molecular signaling pathways that connect TNF-α with the survival of tumor cells. In our experi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14010411

    authors： Pileczki V,Braicu C,Gherman CD,Berindan-Neagoe I

    更新日期：2012-12-24 00:00:00

  • Deletion of SOCS2 Reduces Post-Colitis Fibrosis via Alteration of the TGFβ Pathway.

    abstract：:Inflammatory bowel disease (IBD) is an immunologically mediated chronic intestinal disorder. Growth hormone (GH) administration enhances mucosal repair and decreases intestinal fibrosis in patients with IBD. In the present study, we investigated the effect of cellular sensitivity to GH via suppressor of cytokine signa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093073

    authors： Al-Araimi A,Al Kharusi A,Bani Oraba A,Al-Maney MM,Al Sinawi S,Al-Haddabi I,Zadjali F

    更新日期：2020-04-27 00:00:00

  • Resistance to Recombinant Human Erythropoietin Therapy in a Rat Model of Chronic Kidney Disease Associated Anemia.

    abstract：:This study aimed to elucidate the mechanisms explaining the persistence of anemia and resistance to recombinant human erythropoietin (rHuEPO) therapy in a rat model of chronic kidney disease (CKD)-associated anemia with formation of anti-rHuEPO antibodies. The remnant kidney rat model of CKD induced by 5/6 nephrectomy...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17010028

    authors： Garrido P,Ribeiro S,Fernandes J,Vala H,Rocha-Pereira P,Bronze-da-Rocha E,Belo L,Costa E,Santos-Silva A,Reis F

    更新日期：2015-12-25 00:00:00

  • Is the secret of VDAC Isoforms in their gene regulation? Characterization of human VDAC genes expression profile, promoter activity, and transcriptional regulators.

    abstract：:VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs' presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon-intron organization, and the proteins show the same cha...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197388

    authors： Zinghirino F,Pappalardo XG,Messina A,Guarino F,De Pinto V

    更新日期：2020-10-07 00:00:00

  • A Multi-Scale Study of Water Dynamics under Confinement, Exploiting Numerical Simulations in Relation to NMR Relaxometry, PGSE and NMR Micro-Imaging Experiments: An Application to the Clay/Water Interface.

    abstract：:Water mobility within the porous network of dense clay sediments was investigated over a broad dynamical range by using 2H nuclear magnetic resonance spectroscopy. Multi-quanta 2H NMR spectroscopy and relaxation measurements were first performed to identify the contributions of the various relaxation mechanisms monito...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21134697

    authors： Porion P,Delville A

    更新日期：2020-06-30 00:00:00

  • Drug-Related Cutaneous Adverse Events in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Literature Review.

    abstract：:Since myeloproliferative neoplasms (MPN) pose a significant risk for vascular and thrombotic complications, cytoreductive therapies, such as hydroxyurea (HU), interferon (IFN) inhibitors, and Janus kinase (JAK) inhibitors are recommended for patients at high risk. However, these agents also place patients at increased...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21113900

    authors： Malato A,Rossi E,Palumbo GA,Guglielmelli P,Pugliese N

    更新日期：2020-05-30 00:00:00

  • Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain.

    abstract：:Worldwide, women account for approximately 51% of human immunodeficiency virus-1 (HIV) seropositive individuals. The prevalence of neuropathic pain among individuals with HIV and a lack of preclinical data characterizing sex differences prompted us to address this knowledge gap. C57BL/6 male and female mice received m...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051196

    authors： Guindon J,Blanton H,Brauman S,Donckels K,Narasimhan M,Benamar K

    更新日期：2019-03-09 00:00:00

  • Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway.

    abstract：:In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155436

    authors： Wu PK,Becker A,Park JI

    更新日期：2020-07-30 00:00:00

  • Membrane Repair Deficit in Facioscapulohumeral Muscular Dystrophy.

    abstract：:Deficits in plasma membrane repair have been identified in dysferlinopathy and Duchenne Muscular Dystrophy, and contribute to progressive myopathy. Although Facioscapulohumeral Muscular Dystrophy (FSHD) shares clinicopathological features with these muscular dystrophies, it is unknown if FSHD is characterized by plasm...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21155575

    authors： Bittel AJ,Sreetama SC,Bittel DC,Horn A,Novak JS,Yokota T,Zhang A,Maruyama R,Rowel Q Lim K,Jaiswal JK,Chen YW

    更新日期：2020-08-04 00:00:00

  • Photochemistry and Cytotoxicity Evaluation of Heptamethinecyanine Near Infrared (NIR) Dyes.

    abstract：:The present study investigates the photochemical properties of potential photosensitizers for photodynamic therapy, namely four commercial heptamethinecyanine dyes (IR125, IR780, IR813, IR820). Spectroscopic studies were made by means of laser induced fluorescence and laser flash photolysis in order to obtain fluoresc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140918557

    authors： Conceição DS,Ferreira DP,Ferreira LF

    更新日期：2013-09-09 00:00:00

  • Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors.

    abstract：:The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In this study, we utiliz...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20112686

    authors： Sassetti E,Durante Cruz C,Tammela P,Winterhalter M,Augustyns K,Gribbon P,Windshügel B

    更新日期：2019-05-31 00:00:00

  • Myosin and Other Energy-Transducing ATPases: Structural Dynamics Studied by Electron Paramagnetic Resonance.

    abstract：:The objective of this article was to document the energy-transducing and regulatory interactions in supramolecular complexes such as motor, pump, and clock ATPases. The dynamics and structural features were characterized by motion and distance measurements using spin-labeling electron paramagnetic resonance (EPR) spec...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21020672

    authors： Arata T

    更新日期：2020-01-20 00:00:00

  • Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach.

    abstract：:Antibodies are composed of structurally and functionally independent domains that can be used as building blocks to construct different types of chimeric protein-format molecules. However, the generally used genetic fusion and chemical approaches restrict the types of structures that can be formed and do not give an i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21030711

    authors： Ueda A,Umetsu M,Nakanishi T,Hashikami K,Nakazawa H,Hattori S,Asano R,Kumagai I

    更新日期：2020-01-21 00:00:00

  • p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation.

    abstract：:Protein-bound uremic toxins, such as p-cresol sulfate (PCS), can be accumulated with declined renal function and aging and is closely linked with central nervous system (CNS) diseases. In the periphery, PCS has effects on oxidative stress and inflammation. Since oxidative stress and inflammation have substantial roles...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21186687

    authors： Sun CY,Li JR,Wang YY,Lin SY,Ou YC,Lin CJ,Wang JD,Liao SL,Chen CJ

    更新日期：2020-09-12 00:00:00

  • Methodology of Drought Stress Research: Experimental Setup and Physiological Characterization.

    abstract：:Drought is one of the major stress factors affecting the growth and development of plants. In this context, drought-related losses of crop plant productivity impede sustainable agriculture all over the world. In general, plants respond to water deficits by multiple physiological and metabolic adaptations at the molecu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19124089

    authors： Osmolovskaya N,Shumilina J,Kim A,Didio A,Grishina T,Bilova T,Keltsieva OA,Zhukov V,Tikhonovich I,Tarakhovskaya E,Frolov A,Wessjohann LA

    更新日期：2018-12-17 00:00:00

  • Cryopreservation Differentially Alters the Proteome of Epididymal and Ejaculated Pig Spermatozoa.

    abstract：:Cryopreservation induces differential remodeling of the proteome in mammalian spermatozoa. How these proteome changes relate to the loss of sperm function during cryopreservation remains unsolved. The present study aimed to clarify this issue evaluating differential changes in the proteome of fresh and frozen-thawed p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20071791

    authors： Perez-Patiño C,Barranco I,Li J,Padilla L,Martinez EA,Rodriguez-Martinez H,Roca J,Parrilla I

    更新日期：2019-04-11 00:00:00

  • More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones.

    abstract：:There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20246124

    authors： Arnedo M,Latorre-Pellicer A,Lucia-Campos C,Gil-Salvador M,Antoñanzas-Peréz R,Gómez-Puertas P,Bueno-Lozano G,Puisac B,Pié J

    更新日期：2019-12-04 00:00:00

  • Immunological effects of Oenothein B, an ellagitannin dimer, on dendritic cells.

    abstract：:Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been discussed, while the ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms14010046

    authors： Yoshimura M,Akiyama H,Kondo K,Sakata K,Matsuoka H,Amakura Y,Teshima R,Yoshida T

    更新日期：2012-12-20 00:00:00

  • Prognostic Role of Survivin and Macrophage Infiltration Quantified on Protein and mRNA Level in Molecular Subtypes Determined by RT-qPCR of KRT5, KRT20, and ERBB2 in Muscle-Invasive Bladder Cancer Treated by Adjuvant Chemotherapy.

    abstract：OBJECTIVES:Bladder cancer is a heterogeneous malignancy. Therefore, it is difficult to find single predictive markers. Moreover, most studies focus on either the immunohistochemical or molecular assessment of tumor tissues by next-generation sequencing (NGS) or PCR, while a combination of immunohistochemistry (IHC) and...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197420

    authors： Ecke TH,Kiani A,Schlomm T,Friedersdorff F,Rabien A,Jung K,Kilic E,Boström P,Tervahartiala M,Taimen P,Gleichenhagen J,Johnen G,Brüning T,Koch S,Roggisch J,Wirtz RM

    更新日期：2020-10-08 00:00:00

  • The neuroprotective functions of transforming growth factor beta proteins.

    abstract：:Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13078219

    authors： Dobolyi A,Vincze C,Pál G,Lovas G

    更新日期：2012-01-01 00:00:00

  • Mechanisms of Stress-Induced Spermatogenesis Impairment in Male Rats Following Unpredictable Chronic Mild Stress (uCMS).

    abstract：:The negative association between psychological stress and male fertility has been known for many years. This study was aimed at (i) identifying spermatogenesis impairment induced by psychological stress in rats and (ii) exploring the role of glucocorticoid receptor (GR) signaling in these adverse effects (if they exis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184470

    authors： Zou P,Wang X,Yang W,Liu C,Chen Q,Yang H,Zhou N,Zeng Y,Chen H,Zhang G,Liu J,Cao J,Ao L,Sun L

    更新日期：2019-09-10 00:00:00

  • Proteomics and Metabolomics for Cystic Fibrosis Research.

    abstract：:The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155439

    authors： Liessi N,Pedemonte N,Armirotti A,Braccia C

    更新日期：2020-07-30 00:00:00

  • MiR-19a Overexpression in FTC-133 Cell Line Induces a More De-Differentiated and Aggressive Phenotype.

    abstract：:In recent years, microRNAs (miRNAs) have received increasing attention for their important role in tumor initiation and progression. MiRNAs are a class of endogenous small non-coding RNAs that negatively regulate the expression of several oncogenes or tumor suppressor genes. MiR-19a, a component of the oncogenic miR-1...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123944

    authors： Calabrese G,Dolcimascolo A,Torrisi F,Zappalà A,Gulino R,Parenti R

    更新日期：2018-12-07 00:00:00

  • Characterization of the interaction between eupatorin and bovine serum albumin by spectroscopic and molecular modeling methods.

    abstract：:This study investigated the interaction between eupatorin and bovine serum albumin (BSA) using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopies, and molecular modeling at pH 7.4. Results of UV-vis and fluorescence spectroscopies illustrated that BS...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms140714185

    authors： Xu H,Yao N,Xu H,Wang T,Li G,Li Z

    更新日期：2013-07-09 00:00:00

  • G Protein-Coupled Receptors in Cancer.

    abstract：:Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development. I...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17081320

    authors： Bar-Shavit R,Maoz M,Kancharla A,Nag JK,Agranovich D,Grisaru-Granovsky S,Uziely B

    更新日期：2016-08-12 00:00:00

  • Mechanisms of Arrhythmias in the Brugada Syndrome.

    abstract：:Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada synd...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21197051

    authors： Blok M,Boukens BJ

    更新日期：2020-09-25 00:00:00

  • In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models.

    abstract：:Atherosclerosis is a multifactorial chronic disease that affects large arteries and may lead to fatal consequences. According to current understanding, inflammation and lipid accumulation are the two key mechanisms of atherosclerosis development. Animal models based on genetically modified mice have been developed to ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21062097

    authors： Poznyak AV,Grechko AV,Wetzker R,Orekhov AN

    更新日期：2020-03-18 00:00:00

  • Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells.

    abstract：:Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a "natural cancer fighter", being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141223545

    authors： Shafie NH,Esa NM,Ithnin H,Saad N,Pandurangan AK

    更新日期：2013-12-02 00:00:00

  • Lack of Cannabinoid Receptor Type-1 Leads to Enhanced Age-Related Neuronal Loss in the Locus Coeruleus.

    abstract：:Our laboratory and others have previously shown that cannabinoid receptor type-1 (CB1r) activity is neuroprotective and a modulator of brain ageing; a genetic disruption of CB1r signaling accelerates brain ageing, whereas the pharmacological stimulation of CB1r activity had the opposite effect. In this study, we have ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010005

    authors： Gargano A,Beins E,Zimmer A,Bilkei-Gorzo A

    更新日期：2020-12-22 00:00:00