Abstract:
:Hepatocyte growth factor (HGF) is an endogenously expressed bioactive substance that has a strong anti-apoptotic effect. In this study, we biochemically and histologically characterized the effects of rh-HGF on in vitro human hepatocyte injury and mouse acute liver failure (ALF) models, both of which were induced by antibody-mediated Fas signaling. rh-HGF inhibited intracellular caspase-3/7 activation and cytokeratin 18 (CK-18) fragment release in both models. Histologically, rh-HGF dramatically suppressed parenchymal damage and intrahepatic hemorrhage. Among the laboratory parameters, prothrombin time (PT) was strongly preserved by rh-HGF, and PT was well correlated with the degree of intrahepatic hemorrhage. These results showed that the anti-apoptotic effect of rh-HGF on hepatocytes coincided strikingly with the suppression of intrahepatic hemorrhage. PT was considered to be the best parameter that correlated with the intrahepatic hemorrhages associated with hepatocellular damage. The action of rh-HGF might derive not only from its anti-apoptosis effects on liver parenchymal cells but also from its stabilization of structural and vasculature integrity.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Motoi S,Toyoda H,Obara T,Ohta E,Arita Y,Negishi K,Moriya K,Kuboi Y,Soejima M,Imai T,Ido A,Tsubouchi H,Kawano Tdoi
10.3390/ijms20081821subject
Has Abstractpub_date
2019-04-12 00:00:00issue
8issn
1422-0067pii
ijms20081821journal_volume
20pub_type
杂志文章abstract::The prediction of drug-target interactions (DTIs) via computational technology plays a crucial role in reducing the experimental cost. A variety of state-of-the-art methods have been proposed to improve the accuracy of DTI predictions. In this paper, we propose a kind of drug-target interactions predictor adopting mul...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081781
更新日期:2017-08-16 00:00:00
abstract::Laser-driven accelerators allow to generate ultrashort (from femto- to picoseconds) high peak dose-rate (up to tens of GGy/s) accelerated particle beams. However, the radiobiological effects of ultrashort pulsed irradiation are still poorly studied. The aim of this work was to compare the formation and elimination of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249488
更新日期:2020-12-14 00:00:00
abstract::The genus of Termitomyces purchased from the market has been identified as Termitomyces eurrhizus using the Internal Transcribed Spacer (ITS) method. An α-galactosidase from T. eurrhizus (TEG), a monomeric protein with a molecular mass of 72 kDa, was purified 146 fold by employing ion exchange chromatography and gel f...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161226159
更新日期:2015-12-08 00:00:00
abstract::Relaxin is known to play an important role in animal pregnancies, including those of humans. It is suggested that relaxin induces aggressive cell growth and invasiveness in several types of cancer, including endometrial cancer. However, the mechanisms of relaxin remain largely unclear. In this study, we examined the e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082438
更新日期:2018-08-18 00:00:00
abstract::Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in the role of these molecules on arterial calcification. The purinergic ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21207636
更新日期:2020-10-15 00:00:00
abstract::Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease caused by an unstable cardiotocography (CTG) repeat expansion in the DMPK gene. This disease is characterized by high clinical and genetic variability, leading to some difficulties in the diagnosis and prognosis of DM1. Better understanding the origin ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21020457
更新日期:2020-01-10 00:00:00
abstract::Ten articles published in the "Special Issue: Salicylic Acid Signalling in Plants" are summarized, in order to get a global picture about the mode of action of salicylic acid in plants, and about its interaction with other stress-signalling routes. Its ecological aspects and possible practical use are also discussed. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms21072655
更新日期:2020-04-10 00:00:00
abstract::Among classical BCR-ABL-negative myeloproliferative neoplasms (MPN), primary myelofibrosis (PMF) is the most aggressive subtype from a clinical standpoint, posing a great challenge to clinicians. Whilst the biological consequences of the three MPN driver gene mutations (JAK2, CALR, and MPL) have been well described, r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21238885
更新日期:2020-11-24 00:00:00
abstract::Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. Recent evidenc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17040552
更新日期:2016-04-13 00:00:00
abstract::Neural diseases including injury by endogenous factors, traumatic brain injury, and degenerative neural injury are eventually due to reactive oxygen species (ROS). Thus ROS generation in neural tissues is a hallmark feature of numerous forms of neural diseases. Neural degeneration and the neural damage process is comp...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms160819657
更新日期:2015-08-19 00:00:00
abstract::MicroRNAs (miRNAs) play an essential role in the regulation of almost all the biological processes, including melanogenesis. MiR-27a-3p is nearly six times higher in white alpaca skin compared to brown skin, which indicates that miR-27a-3p may be a candidate regulator for melanogenesis. Wnt3a plays an important role i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160510921
更新日期:2015-05-14 00:00:00
abstract::Maintaining a robust epithelial barrier requires the accumulation of tight junction proteins, LSR/angulin-1 and tricellulin, at the tricellular contacts. Alterations in the localization of these proteins temporarily cause epithelial barrier dysfunction, which is closely associated with not only physiological different...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20143555
更新日期:2019-07-20 00:00:00
abstract::Niemann-Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010452
更新日期:2021-01-05 00:00:00
abstract::MicroRNAs (miRNAs), a class of single stranded, small (~22 nucleotides), non-coding RNAs, play an important role in muscle development. We focused on the role of the miR-30-5p family during bovine muscle development from previous high-throughput sequencing results and analyzed their expression profiles. MHC and MyoG m...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17020182
更新日期:2016-01-29 00:00:00
abstract::We report molecular dynamics simulations of confined liquid crystals using the Gay-Berne-Kihara model. Upon isobaric cooling, the standard sequence of isotropic-nematic-smectic A phase transitions is found. Upon further cooling a reentrant nematic phase occurs. We investigate the temperature dependence of the self-dif...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13067854
更新日期:2012-01-01 00:00:00
abstract::Expression of human granulocyte macrophage colony stimulating factor (hGMCSF), a cytokine of therapeutic importance, as a thioredoxin (TRX) fusion has been investigated in Escherichia coli BL21 (DE3) codon plus cells. The expression of this protein was low when cloned under the T7 promoter without any fusion tags. Hig...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12032064
更新日期:2011-01-01 00:00:00
abstract::Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells, generating a communication network. Exosomes strongly contribute to the immune suppressive tumor microenvironment of head and neck squamous cell carcinomas (HNSCC). I...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21114072
更新日期:2020-06-06 00:00:00
abstract::MicroRNAs are 18-22 nucleotides long, non-coding RNAs that bind transcripts with complementary sequences leading to either mRNA degradation or translational suppression. However, the inherent differences in preferred mode of miRNA regulation among cells of different origin have not been examined. In our previous trans...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010072
更新日期:2016-01-08 00:00:00
abstract::TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wast...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092312
更新日期:2019-05-10 00:00:00
abstract::Kawasaki syndrome (KS) is the most relevant cause of heart disease in children living in developed countries. Intravenous immunoglobulin (IVIG) has a preventive function in the formation of coronary artery abnormalities and a poor strictly-curative action in established coronary damage. More than two decades ago, the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17030278
更新日期:2016-02-24 00:00:00
abstract:BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was sugg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184373
更新日期:2019-09-06 00:00:00
abstract::Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18030561
更新日期:2017-03-04 00:00:00
abstract::Maize ZmC1 and ZmR transcription factors belong to the MYB-type and bHLH families, respectively, and control anthocyanin biosynthesis. In this study, Agrobacterium-mediated transformation was used to generate transgenic wheat plants that overexpress ZmC1 and ZmR or both, with the objective of developing anthocyanin-en...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20225806
更新日期:2019-11-19 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,已发布勘误
doi:10.3390/ijms21124560
更新日期:2020-06-26 00:00:00
abstract::A series of new 2-aminobenzamide derivatives (1-10) has been synthesized in good to excellent yields by adopting both conventional and/or a time-efficient microwave assisted methodologies starting from isatoic anhydride (ISA) and characterized on the basis of their physical, spectral and microanalytical data. Selected...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15035115
更新日期:2014-03-21 00:00:00
abstract::Ceramides are key lipids in energetic-metabolic pathways and signaling cascades, modulating critical physiological functions in cells. While synthesis of ceramides is performed in endoplasmic reticulum (ER), which is altered under overnutrition conditions, proteins associated with ceramide metabolism are located on me...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092527
更新日期:2018-08-26 00:00:00
abstract::Administration of oxygen is one of the most common interventions in medicine. Previous research showed that differential regulated proteins could be linked to hyperoxia-associated signaling cascades in different tissues. However, it still remains unclear which signaling pathways are activated by hyperoxia. The present...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071960
更新日期:2018-07-04 00:00:00
abstract::Aegilops geniculata Roth has been used as a donor of disease-resistance genes, to enrich the gene pool for wheat (Triticum aestivum) improvement through distant hybridization. In this study, the wheat-Ae. geniculata alien disomic substitution line W16998 was obtained from the BC1F8 progeny of a cross between the commo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051861
更新日期:2020-03-09 00:00:00
abstract::The tumor vasculature is essential for tumor growth and metastasis, and is a prime target of several anti-cancer agents. Increasing evidence indicates that tumor angiogenesis is stimulated by extracellular vesicles (EVs) that are secreted or shed by cancer cells. These EVs encapsulate a variety of biomolecules with an...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155418
更新日期:2020-07-30 00:00:00
abstract::The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our purpose was to determine p16 clinical and biological significance in CC. p16 expression pattern was ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062125
更新日期:2020-03-19 00:00:00