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The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer.

Abstract：

:Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells, generating a communication network. Exosomes strongly contribute to the immune suppressive tumor microenvironment of head and neck squamous cell carcinomas (HNSCC). Isolation of exosomes from HNSCC cell culture or patient's plasma allows for analyzing their molecular cargo and functional role in immune suppression and tumor progression. Immune affinity-based separation of different exosome subsets, such as tumor-derived or T cell-derived exosomes, from patient's plasma simultaneously informs about tumor status and immune dysfunction. In this review, we discuss the recent understanding of how exosomes behave in the HNSCC tumor microenvironment and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy in HNSCC.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Hofmann L,Ludwig S,Vahl JM,Brunner C,Hoffmann TK,Theodoraki MN

doi

10.3390/ijms21114072

subject

Has Abstract

pub_date

2020-06-06 00:00:00

issue

11

issn

1422-0067

pii

ijms21114072

journal_volume

21

pub_type

杂志文章,评审

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