Abstract：
:The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Piccinin E,Arconzo M,Graziano G,Vacca M,Peres C,Bellafante E,Villani G,Moschetta Adoi
10.3390/ijms20225735subject
Has Abstractpub_date
2019-11-15 00:00:00issue
22issn
1422-0067pii
ijms20225735journal_volume
20pub_type
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