Abstract：
:Abnormal uterine function affects conception rate and embryo development, thereby leading to poor fertility and reproduction failure. Exosomes are a nanosized subclass of extracellular vesicles (EV) that have important functions as intercellular communicators. They contain and carry transferable bioactive substances including micro RNA (miRNA) for target cells. Elements of the cargo can provide epigenetic modifications of the recipient cells and may have crucial roles in mechanisms of reproduction. The dairy industry accounts for a substantial portion of the economy of many agricultural countries. Exosomes can enhance the expression of inflammatory mediators in the endometrium, which contribute to various inflammatory diseases in transition dairy cows. This results in reduced fertility which leads to reduced milk production and increased cow maintenance costs. Thus, gaining a clear knowledge of exosomal epigenetic modifiers is critical to improving the breeding success and profitability of dairy farms. This review provides a brief overview of how exosomal miRNA contributes to inflammatory diseases and hence to poor fertility, particularly in dairy cows.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Abeysinghe P,Turner N,Morean Garcia I,Mosaad E,Peiris HN,Mitchell MDdoi
10.3390/ijms21239106subject
Has Abstractpub_date
2020-11-30 00:00:00issue
23issn
1422-0067pii
ijms21239106journal_volume
21pub_type
杂志文章,评审abstract：:Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be severely pathogenic for the fetus during pregnancy and in immunocompromised persons, such as transplant recipients or HIV infected patients. HCMV ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-07-24 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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pub_type： 杂志文章,评审
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更新日期：2013-05-29 00:00:00
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更新日期：2021-01-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-04-02 00:00:00
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pub_type： 杂志文章
doi：10.3390/ijms12085449
更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160818741
更新日期：2015-08-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205147
更新日期：2019-10-17 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112425
更新日期：2017-11-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047851
更新日期：2015-04-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,多中心研究
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-09-21 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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