Abstract：
:The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abundant dietary flavonoid, is emerging as a potential regulator of inflammation. Here, we show that apigenin has immune-regulatory activity in vivo. Apigenin conferred survival to mice treated with a lethal dose of Lipopolysaccharide (LPS) restoring normal cardiac function and heart mitochondrial Complex I activity. Despite the adverse effects associated with high levels of splenocyte apoptosis in septic models, apigenin had no effect on reducing cell death. However, we found that apigenin decreased LPS-induced apoptosis in lungs, infiltration of inflammatory cells and chemotactic factors' accumulation, re-establishing normal lung architecture. Using NF-κB luciferase transgenic mice, we found that apigenin effectively modulated NF-κB activity in the lungs, suggesting the ability of dietary compounds to exert immune-regulatory activity in an organ-specific manner. Collectively, these findings provide novel insights into the underlying immune-regulatory mechanisms of dietary nutraceuticals in vivo.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cardenas H,Arango D,Nicholas C,Duarte S,Nuovo GJ,He W,Voss OH,Gonzalez-Mejia ME,Guttridge DC,Grotewold E,Doseff AIdoi
10.3390/ijms17030323subject
Has Abstractpub_date
2016-03-01 00:00:00pages
323issue
3issn
1422-0067pii
ijms17030323journal_volume
17pub_type
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