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Ultrastructural interactions and genotoxicity assay of cerium dioxide nanoparticles on mouse oocytes.

Abstract：

:Cerium dioxide nanoparticles (C(e)O₂ ENPs) are on the priority list of nanomaterials requiring evaluation. We performed in vitro assays on mature mouse oocytes incubated with C(e)O₂ ENPs to study (1) physicochemical biotransformation of ENPs in culture medium; (2) ultrastructural interactions with follicular cells and oocytes using Transmission Electron Microscopy (TEM); (3) genotoxicity of C(e)O₂ ENPs on follicular cells and oocytes using a comet assay. DNA damage was quantified as Olive Tail Moment. We show that ENPs aggregated, but their crystal structure remained stable in culture medium. TEM showed endocytosis of C(e)O₂ ENP aggregates in follicular cells. In oocytes, C(e)O₂ ENP aggregates were only observed around the zona pellucida (ZP). The comet assay revealed significant DNA damage in follicular cells. In oocytes, the comet assay showed a dose-related increase in DNA damage and a significant increase only at the highest concentrations. DNA damage decreased significantly both in follicular cells and in oocytes when an anti-oxidant agent was added in the culture medium. We hypothesise that at low concentrations of C(e)O₂ ENPs oocytes could be protected against indirect oxidative stress due to a double defence system composed of follicular cells and ZP.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Courbiere B,Auffan M,Rollais R,Tassistro V,Bonnefoy A,Botta A,Rose J,Orsière T,Perrin J

doi

10.3390/ijms141121613

subject

Has Abstract

pub_date

2013-10-31 00:00:00

pages

21613-28

issue

11

issn

1422-0067

pii

ijms141121613

journal_volume

14

pub_type

杂志文章

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