Abstract:
:Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, however, remain unclear. The inhibitory effects of these antidepressants for neuropathic pain manifest more quickly than their antidepressive effects, suggesting different modes of action. Recent studies of animal models of neuropathic pain revealed that noradrenaline is extremely important for the inhibition of neuropathic pain. First, increasing noradrenaline in the spinal cord by reuptake inhibition directly inhibits neuropathic pain through α₂-adrenergic receptors. Second, increasing noradrenaline acts on the locus coeruleus and improves the function of an impaired descending noradrenergic inhibitory system. Serotonin and dopamine may reinforce the noradrenergic effects to inhibit neuropathic pain. The mechanisms of neuropathic pain inhibition by antidepressants based mainly on experimental findings from animal models of neuropathic pain are discussed in this review.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Obata Hdoi
10.3390/ijms18112483subject
Has Abstractpub_date
2017-11-21 00:00:00issue
11issn
1422-0067pii
ijms18112483journal_volume
18pub_type
杂志文章,评审abstract::The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidate...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155559
更新日期:2020-08-03 00:00:00
abstract::The risk of prostate cancer has been increasing in men by degrees. To develop a new prostate cancer therapy, we used a stem cell-derived gene directed prodrug enzyme system using human neural stem cells (hNSCs) that have a tumor-tropic effect. These hNSCs were transduced with the therapeutic genes for bacterial cytosi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131012519
更新日期:2012-09-28 00:00:00
abstract::Adsorption of precious metals in acidic aqueous solutions using thiourea modified magnetic magnetite nanoparticle (MNP-Tu) was examined. The MNP-Tu was synthesized, characterized and examined as a reusable adsorbent for the recovery of precious metals. The adsorption kinetics were well fitted with pseudo second-order e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14059834
更新日期:2013-05-08 00:00:00
abstract::Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine. Pegylated arginine...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061175
更新日期:2017-06-01 00:00:00
abstract::Recently, extreme ultraviolet (EUV) radiation has been increasingly used to modify polymers. Properties such as the extremely short absorption lengths in polymers and the very strong interaction of EUV photons with materials may play a key role in achieving new biomaterials. The purpose of the study was to examine the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249679
更新日期:2020-12-18 00:00:00
abstract::Neuroblastoma is the most common extracranial solid tumor in childhood. The different treatments available for neuroblastoma are challenged by high rates of resistance, recurrence, and progression, most notably in advanced cases and highly malignant tumors. Therefore, the development of more targeted therapies, which ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186792
更新日期:2020-09-16 00:00:00
abstract::Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report con...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms131114385
更新日期:2012-11-07 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality, projected to become the 3rd cause of disease mortality worldwide by 2020. COPD is characterized by persistent and not fully reversible airflow limitation that is usually progressive and is associated with an abnormal chron...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18112449
更新日期:2017-11-18 00:00:00
abstract::Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary veg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122652
更新日期:2017-12-07 00:00:00
abstract::Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTP...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21176312
更新日期:2020-08-31 00:00:00
abstract::Wilms tumor protein-1 (WT1) is an attractive target for adoptive T-cell therapy due to its expression in solid tumors and hematologic malignancies. However, T cells recognizing WT1 occur in low frequencies in the peripheral blood of healthy donors, limiting potential therapeutic possibilities. Tin mesoporphyrin (SnMP)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030482
更新日期:2019-01-23 00:00:00
abstract::As an angiogenesis inhibitor, bevacizumab has been investigated in combination with different chemotherapeutic agents, achieving an established role for metastatic cancer treatment. However, potential synergic anti-angiogenic effects of hyperthermia have not tested to date in literature. The aim of our study was to an...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071458
更新日期:2017-07-06 00:00:00
abstract::The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence. C57/BL6 female mice that were 14 ± 3 months old were infused with either Angiotensin II (AngII) or saline subcutaneously for two weeks. These mice were administered CGA of 2...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124527
更新日期:2020-06-25 00:00:00
abstract::Stable five-coordinate Pt(II) complexes have been highlighted as a promising and original platform for the development of new cytotoxic drugs. Their interaction with proteins has been scarcely studied. Here, the reactivity of the five-coordinate Pt(II) compound [Pt(I)(Me) (dmphen)(olefin)] (Me = methyl, dmphen = 2,9-d...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030520
更新日期:2019-01-26 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a key process in cancer development and progression. Communication (crosstalk) between cancer cells and normal (nonmalignant) cells may facilitate cancer progression. Conditioned medium (CM) obtained from cultured cancer cells contains secreted factors capable of affecting ph...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081528
更新日期:2017-08-01 00:00:00
abstract::Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicoc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15057444
更新日期:2014-04-29 00:00:00
abstract::His-tag technology was applied for biosensing purposes involving multi-redox center proteins (MRPs). An overview is presented on various surfaces ranging from flat to spherical and modified with linker molecules with nitrile-tri-acetic acid (NTA) terminal groups to bind his-tagged proteins in a strict orientation. The...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17030330
更新日期:2016-03-03 00:00:00
abstract::Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was alwa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12129083
更新日期:2011-01-01 00:00:00
abstract::Safflower (Carthamus tinctorius L.), an important traditional Chinese medicine, is cultured widely for its pharmacological effects, but little is known regarding the genes related to the metabolic regulation of the safflower's yellow pigment. To investigate genes related to safflor yellow biosynthesis, 454 pyrosequenc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161025657
更新日期:2015-10-26 00:00:00
abstract::Following major advances in the field of medicinal chemistry, novel drugs can now be designed systematically, instead of relying on old trial and error approaches. Current drug design strategies can be classified as being either ligand- or structure-based depending on the design process. In this paper, by describing t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms12085304
更新日期:2011-01-01 00:00:00
abstract::Interstitial telomeric sequences (ITSs) are short stretches of telomeric-like repeats (TTAGGG)n at nonterminal chromosomal sites. We previously demonstrated that, in the genomes of primates and rodents, ITSs were inserted during the repair of DNA double-strand breaks. These conclusions were derived from sequence compa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082838
更新日期:2020-04-18 00:00:00
abstract::The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031077
更新日期:2021-01-22 00:00:00
abstract::The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane receptor, alpha 2 beta 1, responsible for firm attachment of platelets t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14022832
更新日期:2013-01-29 00:00:00
abstract::We have reported that conventional protein kinase Cγ (cPKCγ)-modulated neuron-specific autophagy improved the neurological outcome of mice following ischemic stroke through the Akt-mechanistic target of rapamycin (mTOR) pathway. However, its detailed molecular mechanism remains unclear. In this study, prim...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051380
更新日期:2018-05-06 00:00:00
abstract::Ordered mesoporous silica (OMS) is a very interesting nanostructured material for the design and engineering of new target and controlled drug-delivery systems. Particularly relevant is the interaction between OMS and proteins. Large pores (6–9 nm) micrometric particles can be used for the realization of a drug depot ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19071991
更新日期:2018-07-08 00:00:00
abstract::Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,多中心研究
doi:10.3390/ijms18040837
更新日期:2017-04-14 00:00:00
abstract::Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders associated with social and behavioral impairments. Although dysfunctions in several signaling pathways have been associated with ASDs, very few molecules have been identified as potentially effective drug targets in the clinic. Classica...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093293
更新日期:2020-05-06 00:00:00
abstract::Defensins are small and rather ubiquitous cysteine-rich anti-microbial peptides. These proteins may act against pathogenic microorganisms either directly (by binding and disrupting membranes) or indirectly (as signaling molecules that participate in the organization of the cellular defense). Even though defensins are ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249380
更新日期:2020-12-09 00:00:00
abstract::Psoriasis is a chronic inflammatory skin disease characterized by excessive growth of keratinocytes and hyperkeratosis in the epidermis. An abnormality of the non-lesional epidermis at an early stage of psoriasis is involved in triggering inflammatory cell infiltration into the dermis. Integrin α5β1 acts as a receptor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20133144
更新日期:2019-06-27 00:00:00
abstract::The silk gland synthesizes and secretes a large amount of protein and stores liquid silk protein at an extremely high concentration. Interestingly, silk proteins and serine protease inhibitors are orderly arranged in the silk gland lumen and cocoon shells. Silk fiber formation and the spinning mechanism have not been ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20102491
更新日期:2019-05-20 00:00:00