Abstract:
:In a recent study, we investigated the antimicrobial activity of a collection of resveratrol-derived monomers and dimers against a series of foodborne pathogens. Out of the tested molecules, dehydro-δ-viniferin and dehydro-ε-viniferin emerged as the most promising derivatives. To define the structural elements essential to the antimicrobial activity against the foodborne pathogen L. monocytogenes Scott A as a model Gram-positive microorganism, the synthesis of a series of simplified benzofuran-containing derivatives was carried out. The systematic removal of the aromatic moieties of the parent molecules allowed a deeper insight into the most relevant structural features affecting the activity. While the overall structure of compound 1 could not be altered without a substantial loss of antimicrobial activity, the structural simplification of compound 2 (minimal inhibitory concentration (MIC) 16 µg/mL, minimal bactericidal concentration (MBC) >512 µg/mL) led to the analogue 7 with increased activity (MIC 8 µg/mL, MBC 64 µg/mL).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Catinella G,Mattio LM,Musso L,Arioli S,Mora D,Beretta GL,Zaffaroni N,Pinto A,Dallavalle Sdoi
10.3390/ijms21062168subject
Has Abstractpub_date
2020-03-21 00:00:00issue
6issn
1422-0067pii
ijms21062168journal_volume
21pub_type
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