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Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.

Abstract：

:Obesity causes a significant negative impact on health of human beings world-wide. The main reason for weight gain, which eventually leads to obesity, is excessive ingestion of energy above the body's homeostatic needs. Therefore, the elucidation of detailed mechanisms for appetite control is necessary to prevent and treat obesity. N-methyl-d-aspartate (NMDA) receptor is a post-synaptic glutamate receptor and is important for excitatory neurotransmission. It is expressed throughout the nervous system, and is important for long-term potentiation. It requires both ligand (glutamate) and co-agonist (d-serine or glycine) for efficient opening of the channel to allow calcium influx. d-serine is contained in fermented foods and marine invertebrates, and brain d-serine level is maintained by synthesis in vivo and supply from food and gut microbiota. Although the NMDA receptor has been reported to take part in the central regulation of appetite, the role of d-serine had not been addressed. We recently reported that exogenous d-serine administration can suppress appetite and alter food preference. In this review, we will discuss how NMDA receptor and its co-agonist d-seine participate in the control of appetite and food preference, and elaborate on how this system could possibly be manipulated to suppress obesity.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Sasaki T,Matsui S,Kitamura T

doi

10.3390/ijms17071081

subject

Has Abstract

pub_date

2016-07-07 00:00:00

issue

7

issn

1422-0067

pii

ijms17071081

journal_volume

17

pub_type

杂志文章,评审

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