Abstract：
:The challenge of effectively delivering therapeutic agents to brain has led to an entire field of active research devoted to overcome the blood brain barrier (BBB) and efficiently deliver drugs to brain. This review focusses on exploring the facets of a novel platform designed for the delivery of drugs to brain. The platform was constructed based on the hypothesis that a combination of receptor-targeting agent, like transferrin protein, and a cell-penetrating peptide (CPP) will enhance the delivery of associated therapeutic cargo across the BBB. The combination of these two agents in a delivery vehicle has shown significantly improved (p < 0.05) translocation of small molecules and genes into brain as compared to the vehicle with only receptor-targeting agents. The comprehensive details of the uptake mechanisms and properties of various CPPs are illustrated here. The application of this technology, in conjunction with nanotechnology, can potentially open new horizons for the treatment of central nervous system disorders.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sharma G,Lakkadwala S,Modgil A,Singh Jdoi
10.3390/ijms17060806subject
Has Abstractpub_date
2016-05-25 00:00:00issue
6issn
1422-0067pii
ijms17060806journal_volume
17pub_type
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