Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity.

Abstract:

:Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovirus (MCMV) likewise exhibits a distinct tropism for the lung and thus provides an elegant model to study host-pathogen interaction. Accordingly, fundamental features of cytomegalovirus (CMV) pneumonitis have been discovered in mice that correlate with clinical data obtained from humans. Recent studies have provided insight into MCMV cell tropism and localized inflammation after infection of the respiratory tract. Accordingly, the nodular inflammatory focus (NIF) has been identified as the anatomical correlate of immune control in lungs. Several hematopoietic cells involved in antiviral immunity reside in NIFs and their key effector molecules have been deciphered. Here, we review what has been learned from the mouse model with focus on the microanatomy of infection sites and antiviral immunity in MCMV pneumonitis.

journal_name

Int J Mol Sci

authors

Fonseca Brito L,Brune W,Stahl FR

doi

10.3390/ijms20163865

subject

Has Abstract

pub_date

2019-08-08 00:00:00

issue

16

issn

1422-0067

pii

ijms20163865

journal_volume

20

pub_type

杂志文章,评审
  • Structural Basis of Oligomerization of N-Terminal Domain of Spider Aciniform Silk Protein.

    abstract::Spider silk is self-assembled from water-soluble silk proteins through changes in the environment, including pH, salt concentrations, and shear force. The N-terminal domains of major and minor ampullate silk proteins have been found to play an important role in the assembly process through salt- and pH-dependent dimer...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21124466

    authors: Chakraborty R,Fan JS,Lai CC,Raghuvamsi PV,Chee PX,Anand GS,Yang D

    更新日期:2020-06-23 00:00:00

  • Methodology of Drought Stress Research: Experimental Setup and Physiological Characterization.

    abstract::Drought is one of the major stress factors affecting the growth and development of plants. In this context, drought-related losses of crop plant productivity impede sustainable agriculture all over the world. In general, plants respond to water deficits by multiple physiological and metabolic adaptations at the molecu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19124089

    authors: Osmolovskaya N,Shumilina J,Kim A,Didio A,Grishina T,Bilova T,Keltsieva OA,Zhukov V,Tikhonovich I,Tarakhovskaya E,Frolov A,Wessjohann LA

    更新日期:2018-12-17 00:00:00

  • Expression of selected Ginkgo biloba heat shock protein genes after cold treatment could be induced by other abiotic stress.

    abstract::Heat shock proteins (HSPs) play various stress-protective roles in plants. In this study, three HSP genes were isolated from a suppression subtractive hybridization (SSH) cDNA library of Ginkgo biloba leaves treated with cold stress. Based on the molecular weight, the three genes were designated GbHSP16.8, GbHSP17 and...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13055768

    authors: Cao F,Cheng H,Cheng S,Li L,Xu F,Yu W,Yuan H

    更新日期:2012-01-01 00:00:00

  • E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression.

    abstract::Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. Regulation of the TGFβ signaling pathway is of key importance to maintain tissue homeostasis. Perturbation of this signaling pathway has be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms22020476

    authors: Sinha A,Iyengar PV,Ten Dijke P

    更新日期:2021-01-06 00:00:00

  • Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related

    abstract::Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the onco...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218222

    authors: Guadagni S,Farina AR,Cappabianca LA,Sebastiano M,Maccarone R,Zelli V,Clementi M,Chiominto A,Bruera G,Ricevuto E,Fiorentini G,Sarti D,Mackay AR

    更新日期:2020-11-03 00:00:00

  • LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.

    abstract::Updated measurements of charged particle fluxes during the transit from Earth to Mars as well as on site measurements by Curiosity of Martian surface radiation fluxes identified potential health hazards associated with radiation exposure for human space missions. Designing mitigation strategies of radiation risks to a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20010176

    authors: Chatterjee S,Pietrofesa RA,Park K,Tao JQ,Carabe-Fernandez A,Berman AT,Koumenis C,Sielecki T,Christofidou-Solomidou M

    更新日期:2019-01-05 00:00:00

  • Production of MCM-41 Nanoparticles with Control of Particle Size and Structural Properties: Optimizing Operational Conditions during Scale-Up.

    abstract::The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21217899

    authors: Castillo RR,de la Torre L,García-Ochoa F,Ladero M,Vallet-Regí M

    更新日期:2020-10-24 00:00:00

  • Redox Components: Key Regulators of Epigenetic Modifications in Plants.

    abstract::Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, lik...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21041419

    authors: R M SK,Wang Y,Zhang X,Cheng H,Sun L,He S,Hao F

    更新日期:2020-02-19 00:00:00

  • Potential Molecular Pathways Related to Pulmonary Artery Aneurysm Development: Lessons to Learn from the Aorta.

    abstract::Pulmonary arterial hypertension (PAH) is a rare disease caused by pulmonary vascular remodeling. Current vasodilator treatments have substantially improved patients' survival. This improved survival has led to the appearance of complications related to conditions previously underdiagnosed or even ignored, such as pulm...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21072509

    authors: Nuche J,Palomino-Doza J,Ynsaurriaga FA,Delgado JF,Ibáñez B,Oliver E,Escribano Subías P

    更新日期:2020-04-04 00:00:00

  • The Cysteine-Rich Repeat Protein TaCRR1 Participates in Defense against Both Rhizoctonia cerealis and Bipolaris sorokiniana in Wheat.

    abstract::The domain of unknown function 26 (DUF26), harboring a conserved cysteine-rich motif (C-X8-C-X2-C), is unique to land plants. Several cysteine-rich repeat proteins (CRRs), belonging to DUF26-containing proteins, have been implicated in the defense against fungal pathogens in ginkgo, cotton, and maize. However, little ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165698

    authors: Guo F,Shan Z,Yu J,Xu G,Zhang Z

    更新日期:2020-08-09 00:00:00

  • Cryopreservation Differentially Alters the Proteome of Epididymal and Ejaculated Pig Spermatozoa.

    abstract::Cryopreservation induces differential remodeling of the proteome in mammalian spermatozoa. How these proteome changes relate to the loss of sperm function during cryopreservation remains unsolved. The present study aimed to clarify this issue evaluating differential changes in the proteome of fresh and frozen-thawed p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071791

    authors: Perez-Patiño C,Barranco I,Li J,Padilla L,Martinez EA,Rodriguez-Martinez H,Roca J,Parrilla I

    更新日期:2019-04-11 00:00:00

  • Neonatal Seizures and Purinergic Signalling.

    abstract::Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-sei...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21217832

    authors: Menéndez Méndez A,Smith J,Engel T

    更新日期:2020-10-22 00:00:00

  • Genome-Wide Identification and Characterization of the UBP Gene Family in Moso Bamboo (Phyllostachys edulis).

    abstract::The largest group of deubiquitinases-ubiquitin-specific proteases (UBPs)-perform extensive and significant roles in plants, including the regulation of development and stress responses. A comprehensive analysis of UBP genes has been performed in Arabidopsis thaliana, but no systematic study has been conducted in moso ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20174309

    authors: Wu R,Shi Y,Zhang Q,Zheng W,Chen S,Du L,Lu C

    更新日期:2019-09-03 00:00:00

  • Expression and Functional Properties of an Anti-Triazophos High-Affinity Single-Chain Variable Fragment Antibody with Specific Lambda Light Chain.

    abstract::Triazophos is a widely used organophosphorous insecticide that has potentially adverse effects to organisms. In the present study, a high-affinity single-chain variable fragment (scFv) antibody with specific lambda light chain was developed for residue monitoring. First, the specific variable regions were correctly am...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17060823

    authors: Liu R,Liang X,Xiang D,Guo Y,Liu Y,Zhu G

    更新日期:2016-06-07 00:00:00

  • MEF2A Regulates the MEG3-DIO3 miRNA Mega Cluster-Targeted PP2A Signaling in Bovine Skeletal Myoblast Differentiation.

    abstract::Understanding the molecular mechanisms of skeletal myoblast differentiation is essential for studying muscle developmental biology. In our previous study, we reported that knockdown of myocyte enhancer factor 2A (MEF2A) inhibited myoblast differentiation. Here in this study, we further identified that MEF2A controlled...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20112748

    authors: Wang Y,Mei C,Su X,Wang H,Yang W,Zan L

    更新日期:2019-06-04 00:00:00

  • Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination.

    abstract::The bovine immune system is known for its unusual traits relating to immunoglobulin and antiviral responses. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that cause post-translational deimination, contributing to protein moonlighting in health and disease. PADs also regulate extracellular ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082861

    authors: Criscitiello MF,Kraev I,Lange S

    更新日期:2020-04-19 00:00:00

  • Experimental and Kinetic Study on Lignin Depolymerization in Water/Formic Acid System.

    abstract::Microwave-assisted depolymerization of black-liquor lignin in formic acid was studied, concentrating on the yield of liquid fractions as bio-oil 1 (mainly aromatic monomers) and bio-oil 2 (mainly aromatic oligomers) and the distribution of the specific compositions. Bio-oil 1 (9.69%) and bio-oil 2 (54.39%) achieved th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18102082

    authors: Wang Q,Guan S,Shen D

    更新日期:2017-10-01 00:00:00

  • Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury.

    abstract::Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21145062

    authors: Lima R,Monteiro S,Gomes ED,Vasconcelos NL,Assunção-Silva R,Morais M,Salgado AJ,Silva NA

    更新日期:2020-07-17 00:00:00

  • Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma.

    abstract::Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms150711294

    authors: Imai K,Takai K,Hanai T,Shiraki M,Suzuki Y,Hayashi H,Naiki T,Nishigaki Y,Tomita E,Shimizu M,Moriwaki H

    更新日期:2014-06-25 00:00:00

  • Key Developments in Ionic Liquid Crystals.

    abstract::Ionic liquid crystals are materials that combine the classes of liquid crystals and ionic liquids. The first one is based on the multi-billion-dollar flat panel display industry, whilst the latter quickly developed in the past decades into a family of highly-tunable non-volatile solvents. The combination yields materi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17050731

    authors: Alvarez Fernandez A,Kouwer PH

    更新日期:2016-05-16 00:00:00

  • Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells.

    abstract::Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21062109

    authors: Su BC,Li CC,Horng JL,Chen JY

    更新日期:2020-03-19 00:00:00

  • Fruit Antioxidants during Vinegar Processing: Changes in Content and in Vitro Bio-Accessibility.

    abstract:BACKGROUND:Vinegars based on fruit juices could conserve part of the health-associated compounds present in the fruits. However, in general very limited knowledge exists on the consequences of vinegar-making on different antioxidant compounds from fruit. In this study vinegars derived from apple and grape are studied. ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17101658

    authors: Bakir S,Toydemir G,Boyacioglu D,Beekwilder J,Capanoglu E

    更新日期:2016-09-29 00:00:00

  • Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.

    abstract::G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G protein activation during neurological, cardiovascular, sensory and reproductive signaling. Common and unique features of interactions between...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17111930

    authors: Sato T,Kawasaki T,Mine S,Matsumura H

    更新日期:2016-11-18 00:00:00

  • Analogies between digital radio and chemical orthogonality as a method for enhanced analysis of molecular recognition events.

    abstract::Acoustic wave biosensors are a real-time, label-free biosensor technology, which have been exploited for the detection of proteins and cells. One of the conventional biosensor approaches involves the immobilization of a monolayer of antibodies onto the surface of the acoustic wave device for the detection of a specifi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms9020154

    authors: Edmonson PJ,Hunt WD,Stubbs DD,Lee SH

    更新日期:2008-02-01 00:00:00

  • Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.

    abstract::Disturbances in histone acetyltransferases (HATs) are common in cancers. In urothelial carcinoma (UC), p300 and CBP are often mutated, whereas the GNAT family HATs GCN5 and PCAF (General Control Nonderepressible 5, p300/CBP-Associated Factor) are often upregulated. Here, we explored the effects of specific siRNA-media...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18071449

    authors: Koutsogiannouli EA,Wagner N,Hader C,Pinkerneil M,Hoffmann MJ,Schulz WA

    更新日期:2017-07-05 00:00:00

  • Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA.

    abstract::Mature mRNA is generated by the 3' end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3'-UTR lengths that often encode different C-terminal amino acid sequences. It is well-known that this form of post-t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21186460

    authors: Ikeda T,Saito-Takatsuji H,Yoshitomi Y,Yonekura H

    更新日期:2020-09-04 00:00:00

  • Hydroxyapatite Formation Coexists with Amyloid-like Self-Assembly of Human Amelogenin.

    abstract::Tooth enamel is formed in an extracellular environment. Amelogenin, the major component in the protein matrix of tooth enamel during the developing stage, could assemble into high molecular weight structures, regulating enamel formation. However, the molecular structure of amelogenin protein assembly at the functional...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082946

    authors: Zhang J,Wang J,Ma C,Lu J

    更新日期:2020-04-22 00:00:00

  • The cluster [Re6Se8I6]3- induces low hemolysis of human erythrocytes in vitro: protective effect of albumin.

    abstract::The cluster Re6Se8I63- has been shown to induce preferential cell death of a hepatic carcinoma cell line, thus becoming a promising anti-cancer drug. Whether this cluster induces acute hemolysis or if it interacts with albumin remains unclear. The effect of acute exposure of human red blood cells to different concentr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16011728

    authors: Rojas-Mancilla E,Oyarce A,Verdugo V,Zheng Z,Ramírez-Tagle R

    更新日期:2015-01-13 00:00:00

  • Barley β-glucans-containing food enhances probiotic performances of beneficial bacteria.

    abstract::Currently, the majority of prebiotics in the market are derived from non-digestible oligosaccharides. Very few studies have focused on non-digestible long chain complex polysaccharides in relation to their potential as novel prebiotics. Cereals β-glucans have been investigated for immune-modulating properties and bene...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15023025

    authors: Arena MP,Caggianiello G,Fiocco D,Russo P,Torelli M,Spano G,Capozzi V

    更新日期:2014-02-20 00:00:00

  • Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities.

    abstract::Epidermal barrier integrity could be influenced by various factors involved in epidermal cell differentiation and proliferation, cell-cell adhesion, and skin lipids. Dysfunction of this barrier can cause skin disorders, including eczema. Inversely, eczema can also damage the epidermal barrier. These interactions throu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21041194

    authors: Lee AY

    更新日期:2020-02-11 00:00:00