Abstract：
:Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Importantly, nutritional ATIs exacerbated inflammatory bowel disease and features of fatty liver disease and the metabolic syndrome in mice. For Alzheimer's disease (AD), both inflammation and altered insulin resistance are major contributing factors, impacting onset as well as progression of this devastating brain disorder in patients. In this study, we evaluated the impact of dietary ATIs on a well-known rodent model of AD (5xFAD). We assessed metabolic, behavioral, inflammatory, and microbial changes in mice consuming different dietary regimes with and without ATIs, consumed ad libitum for eight weeks. We demonstrate that ATIs, with or without a gluten matrix, had an impact on the metabolism and gut microbiota of 5xFAD mice, aggravating pathological hallmarks of AD. If these findings can be translated to patients, an ATI-depleted diet might offer an alternative therapeutic option for AD and warrants clinical intervention studies.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Dos Santos Guilherme M,Zevallos VF,Pesi A,Stoye NM,Nguyen VTT,Radyushkin K,Schwiertz A,Schmitt U,Schuppan D,Endres Kdoi
10.3390/ijms21176288subject
Has Abstractpub_date
2020-08-31 00:00:00issue
17issn
1422-0067pii
ijms21176288journal_volume
21pub_type
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