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The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species.

Abstract：

:The signaling function of the Na/K-ATPase has been established for 20 years and is widely accepted in the field, with many excellent reports and reviews not cited here. Even though there is debate about the underlying mechanism, the signaling function is unquestioned. This short review looks back at the evolution of Na/K-ATPase signaling, from stimulation by cardiotonic steroids (also known as digitalis-like substances) as specific ligands to stimulation by reactive oxygen species (ROS) in general. The interplay of cardiotonic steroids and ROS in Na/K-ATPase signaling forms a positive-feedback oxidant amplification loop that has been implicated in some pathophysiological conditions.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Pratt RD,Brickman CR,Cottrill CL,Shapiro JI,Liu J

doi

10.3390/ijms19092600

subject

Has Abstract

pub_date

2018-09-01 00:00:00

issue

9

issn

1422-0067

pii

ijms19092600

journal_volume

19

pub_type

杂志文章,评审

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