Abstract:
:Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein kinase (MAPK) is one of several signaling pathways that drive the metabolic adaptation of skeletal muscle to exercise. p38 MAPK also participates in the development of pathological traits resulting from excessive caloric intake and obesity that cause metabolic syndrome and type 2 diabetes (T2D). Whereas p38 MAPK increases insulin-independent glucose uptake and oxidative metabolism in muscles during exercise, it contrastingly mediates insulin resistance and glucose intolerance during metabolic syndrome development. This article provides an overview of the apparent contradicting roles of p38 MAPK in the adaptation of skeletal muscles to exercise and to pathological conditions leading to glucose intolerance and T2D. Here, we focus on the involvement of p38 MAPK in glucose metabolism of skeletal muscle, and discuss the possibility of targeting this pathway to prevent the development of T2D.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bengal E,Aviram S,Hayek Tdoi
10.3390/ijms21186480subject
Has Abstractpub_date
2020-09-04 00:00:00issue
18issn
1422-0067pii
ijms21186480journal_volume
21pub_type
杂志文章,评审abstract::This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of mecA gene and evalu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197106
更新日期:2020-09-26 00:00:00
abstract::Alzheimer's disease (AD) is a common neurodegenerative disease in elderly individuals, and effective therapies are unavailable. This study was designed to investigate the neuroprotective effects of sulforaphane (an activator of NF-E2-related factor 2) on mice with AD-like lesions induced by combined administration of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150814396
更新日期:2014-08-18 00:00:00
abstract::Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show similar metabolomic patterns several years postpartum. Targeted metabol...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249647
更新日期:2020-12-17 00:00:00
abstract::Selectively targeted nanoscale drug delivery systems have recently emerged as promising intravenously therapeutic option for most chronic joint diseases. Here, a newly synthetized dodecapeptide (GE11)-polylactide-co-glycolide (PLGA)-based conjugate was used to prepare smart nanoparticles (NPs) intended for intra-artic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082304
更新日期:2018-08-06 00:00:00
abstract::Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as on...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21144935
更新日期:2020-07-13 00:00:00
abstract::GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golg...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010085
更新日期:2020-12-23 00:00:00
abstract:: Mono-saturated polyprenols (dolichols) have been found in almost all Eukaryotic cells, however, dolichols containing additional saturated bonds at the ω-end, have been identified in A.fumigatus and A.niger. Here we confirm using an LC-ESI-QTOF-MS analysis, that poly-saturated dolichols are abundant in other fila...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20123043
更新日期:2019-06-21 00:00:00
abstract::Acipenseriformes are composed of 25 sturgeon species and two paddlefish species distributed exclusively in the northern hemisphere. The Danube River and the Black Sea were originally inhabited by six sturgeon species but two are extinct and only four are still reproducing currently in the Lower Danube: Huso huso, Acip...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12106796
更新日期:2011-01-01 00:00:00
abstract::It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal fibrosis related to peritoneal dialysis (PD) hasn't been elucidated. This study was therefore conducted to assess the association between M2 and peritoneal fi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140510369
更新日期:2013-05-17 00:00:00
abstract::Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be cons...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18061183
更新日期:2017-06-02 00:00:00
abstract::Sleep remains one of the least understood phenomena in biology, and sleep disturbances are one of the most common behavioral problems in childhood. The etiology of sleep disorders is complex and involves both genetic and environmental factors. Epilepsy is the most popular childhood neurological condition and is charac...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20215483
更新日期:2019-11-04 00:00:00
abstract::Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18020414
更新日期:2017-02-15 00:00:00
abstract::It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis induction and regula...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112313
更新日期:2017-11-02 00:00:00
abstract::Previous study revealed that a specific lignin-carbohydrate preparation, named as lignin-rich enzyme lignin (LREL) derived from plant husk, is a novel toll-like receptor 4 ligand and shows a potent immune-stimulatory activity against dendritic cells (DCs) in vitro. In this report, we investigated immune-stimulatory ac...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19010064
更新日期:2017-12-26 00:00:00
abstract::The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124357
更新日期:2020-06-19 00:00:00
abstract::Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene that belongs to the ELOVL family and regulates the synthesis of very-long-chain fatty acids (VLCFAs) and sphingolipids, from yeast to mammals. Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160716440
更新日期:2015-07-20 00:00:00
abstract::Unfolded protein response (UPR) is a cytoprotective mechanism that alleviates the protein-folding burden in eukaryotic organisms. Moderate activation of UPR is required for maintaining endoplasmic reticulum (ER) homeostasis and profoundly contributes to tumorigenesis. Defects in UPR signaling are implicated in the att...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071832
更新日期:2018-06-21 00:00:00
abstract::Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140816386
更新日期:2013-08-07 00:00:00
abstract::Bruton's tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core structures. Therefore, it is important to secure a novel scaffold that occupi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217919
更新日期:2020-10-25 00:00:00
abstract::The lipophilic composition of wild Arbutus unedo L. berries, collected from six locations in Penacova (center of Portugal), as well as some general chemical parameters, namely total soluble solids, pH, titratable acidity, total phenolic content and antioxidant activity was studied in detail to better understand its po...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160614194
更新日期:2015-06-23 00:00:00
abstract::Solute carrier family 9 isoform 3 (SLC9A3), a Na⁺/H⁺ exchanger, regulates the transepithelial absorption of Na⁺ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens. Loss of the Slc9a3 allele in mice enhances intestinal fluid and...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19010103
更新日期:2017-12-29 00:00:00
abstract::(Pro)renin receptor ((P)RR) is a multi-functional molecule that is related to both the renin-angiotensin system (RAS) and vacuolar H⁺-ATPase (v-ATPase), an ATP-dependent multi-subunit proton pump. Soluble (P)RR (s(P)RR), which consists of the extracellular domain of (P)RR, is present in blood and urine. Elevated plasm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18061313
更新日期:2017-06-20 00:00:00
abstract::ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively. However, the specific receptor of ABA that triggers the positive and negative responses of ABA during immune resp...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21165852
更新日期:2020-08-14 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quarter of adult acute leukemias, and features different outcomes depending on the age of onset. Improvements in ALL genomic analysis achieved thanks to the implementation of next-generation sequencing (NGS) have led to the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20122929
更新日期:2019-06-15 00:00:00
abstract::Goat's milk is a rich source of bioactive compounds (peptides, conjugated linoleic acid, short chain fatty acids, monounsaturated and polyunsaturated fatty acids, polyphenols such as phytoestrogens and minerals among others) that exert important health benefits. However, goat's milk composition depends on the type of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155530
更新日期:2020-08-01 00:00:00
abstract::Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, gen...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160817456
更新日期:2015-07-30 00:00:00
abstract::Interstitial telomeric sequences (ITSs) are short stretches of telomeric-like repeats (TTAGGG)n at nonterminal chromosomal sites. We previously demonstrated that, in the genomes of primates and rodents, ITSs were inserted during the repair of DNA double-strand breaks. These conclusions were derived from sequence compa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082838
更新日期:2020-04-18 00:00:00
abstract::Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms14047089
更新日期:2013-03-28 00:00:00
abstract::Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current 2D and 3D in vitro models. Here, we demonstrated a ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184647
更新日期:2019-09-19 00:00:00
abstract::Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21061978
更新日期:2020-03-13 00:00:00