Abstract：
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journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Marcuzzi E,Angioni R,Molon B,Calì Bdoi
10.3390/ijms20112651subject
Has Abstractpub_date
2019-05-29 00:00:00issue
11issn
1422-0067pii
ijms20112651journal_volume
20pub_type
杂志文章,已发布勘误abstract：:Calcium-dependent protein kinase (CDPK or CPK) and CDPK-related kinase (CRK) play an important role in plant growth, development, and adaptation to environmental stresses. However, their gene families had been yet inadequately investigated in Medicago truncatula. In this study, six MtCRK genes were computationally ide...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031044
更新日期：2021-01-21 00:00:00
abstract：:Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of multiple cardiometabolic pathologies, including obesity, atherosclerot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228675
更新日期：2020-11-17 00:00:00
abstract：:Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle. Indeed, this genotypic and phenotypic variety, together with the adaptability of tumours, results in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071776
更新日期：2019-04-10 00:00:00
abstract：:We investigated the toxicity of benzo[a]pyrene (B[a]P), 1-nitropyrene (1-NP) and 3-nitrobenzanthrone (3-NBA) in A549 cells. Cells were treated for 4 h and 24 h with: B[a]P (0.1 and 1 μM), 1-NP (1 and 10 μM) and 3-NBA (0.5 and 5 μM). Bulky DNA adducts, lipid peroxidation, DNA and protein oxidation and mRNA expression o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17091393
更新日期：2016-08-26 00:00:00
abstract：:Separation of polyphenolic phytochemical compounds from their mixtures with sugars is necessary to produce an added-value sugar-reduced extract with high biological activity from fruit juice processing industry waste streams. The separation characteristics of a binary mixture of rutin and glucose using a Pellicon-2 re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11020672
更新日期：2010-02-09 00:00:00
abstract：:Dietary NaCl depletion increases Na+ and Cl- absorption in the colon, but the mechanisms are not fully understood. So far, we reported that the expression of claudin-7 (CLDN7), a tight junction (TJ) protein, was upregulated in the mice fed with NaCl-depleted diets, but the regulatory mechanism has not been clarified. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041442
更新日期：2020-02-20 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are considered as promising therapeutic agents for neurodegenerative disorders because they can reduce underlying pathology and also repair damaged tissues. Regarding the delivery of MSCs into the brain, intravenous and intra-arterial routes may be less feasible than intraparenchymal and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041272
更新日期：2020-02-13 00:00:00
abstract：:The global spread of bacterial resistance to antibiotics promotes a search for alternative approaches to eradication of pathogenic bacteria. One alternative is using photosensitizers for inhibition of Gram-positive and Gram-negative bacteria under illumination. Due to low penetration of visible light into tissues, app...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133196
更新日期：2019-06-29 00:00:00
abstract：:The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathet...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145117
更新日期：2020-07-20 00:00:00
abstract：:Poly-γ-glutamic acid (γ-PGA) is a biodegradable biopolymer produced by several bacteria, including Bacillus subtilis and other Bacillus species; it has good biocompatibility, is non-toxic, and has various potential biological applications in the food, pharmaceutical, cosmetic, and other industries. In this review, we ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18122644
更新日期：2017-12-07 00:00:00
abstract：:Over the years, there have been many developments and advances in the field of integral membrane protein research. As important pharmaceutical targets, it is paramount to understand the mechanisms of action that govern their structure-function relationships. However, the study of integral membrane proteins is still in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20102605
更新日期：2019-05-27 00:00:00
abstract：:The microRNAs are small RNAs that regulate gene expression at the post-transcriptional level and can be involved in the onset of neurodegenerative diseases and cancer. They are emerging as possible targets for antisense-based therapy, even though the in vivo stability of miRNA analogues is still questioned. We tested ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062001
更新日期：2020-03-15 00:00:00
abstract：:Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610334
更新日期：2014-06-10 00:00:00
abstract：:Some studies have ascribed a protective effect against neurodegenerative diseases to the β-carbolines harman (H) and norharman (NH), which occur mostly in coffee and coffee substitutes. We determined the concentrations of β-carbolines and undesirable compounds (such as acrylamide) in roasted coffee substitute ingredie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155245
更新日期：2020-07-24 00:00:00
abstract：:Acute kidney injury (AKI) in critically ill children and adults is associated with significant short- and long-term morbidity and mortality. As serum creatinine- and urine output-based definitions of AKI have relevant limitations, there is a persistent need for better diagnostics of AKI. Nuclear magnetic resonance (NM...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041187
更新日期：2020-02-11 00:00:00
abstract：:A new aromaticity definition is advanced as the compactness formulation through the ratio between atoms-in-molecule and orbital molecular facets of the same chemical reactivity property around the pre- and post-bonding stabilization limit, respectively. Geometrical reactivity index of polarizability was assumed as pro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11041269
更新日期：2010-03-26 00:00:00
abstract：:Obesity is a worldwide epidemic problem and correlates to varieties of acute or chronic lung diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. An increase of leptin, a kind of adipokine, in lean mice plasma has been found to impair immune responses and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051078
更新日期：2019-03-02 00:00:00
abstract：:Spätzle family proteins activate the Toll pathway and induce antimicrobial peptide (AMP) production against microbial infections. However, the functional importance of Tmspätzle4 (TmSpz4) in the immune response of Tenebrio molitor has not been reported. Therefore, here, we have identified and functionally characterize...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051878
更新日期：2020-03-09 00:00:00
abstract：:Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11082875
更新日期：2010-08-05 00:00:00
abstract：:Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on renal fibrosis has not yet been elucidated. Here, the purpose of the current study is to test the protective effects of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051103
更新日期：2019-03-04 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of noncoding small RNAs, which play a crucial role in post-transcriptional gene regulation. Recently, various reports revealed that miRNAs could be transmitted between species to mediate cross-kingdom regulation by integrating into a specific target gene-mediated regulatory pathway to ex...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19072007
更新日期：2018-07-10 00:00:00
abstract：:Recent studies have identified cyclic GMP-AMP synthase (cGAS) as an important target for treating autoimmune diseases, and several inhibitors of human cGAS (hcGAS) and their structures in complexation with hcGAS have been reported. However, the mechanisms via which these inhibitors interact with hcGAS are not complete...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031164
更新日期：2021-01-25 00:00:00
abstract：:Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu releas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184552
更新日期：2019-09-13 00:00:00
abstract：:The olfactory system, composed of the olfactory organs and the olfactory bulb, allows organisms to interact with their environment and through the detection of odor signals. Olfaction mediates behaviors pivotal for survival, such as feeding, mating, social behavior, and danger assessment. The olfactory organs are dire...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071639
更新日期：2019-04-02 00:00:00
abstract：:It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151017333
更新日期：2014-09-29 00:00:00
abstract：:Mature mRNA is generated by the 3' end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3'-UTR lengths that often encode different C-terminal amino acid sequences. It is well-known that this form of post-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21186460
更新日期：2020-09-04 00:00:00
abstract：:Omics approaches for investigating biological systems were introduced in the mid-1990s and quickly consolidated to become a fundamental pillar of modern biology. The idea of measuring the whole complement of genes, transcripts, proteins, and metabolites has since become widespread and routinely adopted in the pursuit ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21238987
更新日期：2020-11-26 00:00:00
abstract：:The solvatochromic characteristics of flavone and 7-hydroxyflavone were investigated in neat and binary solvent mixtures. The spectral shifts of these solutes were correlated with the Kamlet and Taft parameters (α, β and π*) using linear solvation energy relationships. The multiparametric analysis indicates that both ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12128895
更新日期：2011-01-01 00:00:00
abstract：:Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mutations cause skeletal overgrowth. Although most of the effects of CNP...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031076
更新日期：2021-01-22 00:00:00
abstract：:The nuclear retinoic acid receptors (RARs) function as ligand-dependent transcriptional regulators and include three subtypes (RARα, RARβ and RARγ), which control the expression of specific gene subsets subsequent to ligand binding and to strictly controlled phosphorylation processes. Extracellular matrix (ECM) accumu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131114073
更新日期：2012-10-31 00:00:00
