Abstract：
:Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental cardiac remodeling, and cardiac fibrosis occurring after the injury. This study aimed at discovering the role of the anti-aging protein α-klotho (KL), which is the co-receptor of fibroblast growth factor-23 (FGF23), in cardiac regeneration, fibrosis, and repair. We found that the anti-apoptotic function of soluble KL in isoproterenol-treated H9c2 cardiomyocytes was independent of FGF23 in vitro. In vivo, isoproterenol-induced cardiac fibrosis and cardiomyocyte and endothelial cell apoptosis were reduced by KL treatment. Moreover, the number of Ki67-positive endothelial cells and microvessel density within the isoproterenol-injured myocardium were increased upon KL treatment. However, by using genetic fate-mapping models, no evident cardiomyocyte proliferation within the injured myocardium was detected with or without KL treatment. Collectively, the cardioprotective functions of KL could be predominantly attributed to its anti-apoptotic and pro-survival activities on endothelial cells and cardiomyocytes. KL could be a potential cardioprotective therapeutic agent with anti-apoptotic and pro-survival activities on cardiomyocytes and endothelial cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chen WYdoi
10.3390/ijms21062186subject
Has Abstractpub_date
2020-03-22 00:00:00issue
6issn
1422-0067pii
ijms21062186journal_volume
21pub_type
杂志文章abstract：:The treatment of metastatic breast cancer remained a challenge despite the recent breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional immunophenotyping of 4T1 metastatic breast cancer by the state-of-the-art single cell mass cytometry (CyTOF). We determined the dose and time dependent c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010170
更新日期：2019-12-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103225
更新日期：2018-10-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-03-07 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-04-06 00:00:00
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更新日期：2018-06-25 00:00:00
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更新日期：2020-03-31 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20205213
更新日期：2019-10-21 00:00:00
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更新日期：2016-06-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-11-05 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms19041040
更新日期：2018-03-30 00:00:00
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更新日期：2019-01-05 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-06-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176431
更新日期：2020-09-03 00:00:00
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更新日期：2019-05-11 00:00:00
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更新日期：2015-04-08 00:00:00
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更新日期：2020-01-31 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-23 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-10-31 00:00:00
abstract：:Environmental issues pose huge threats to public health, particularly the damage caused by fine particulate matter (PM2.5). However, the mechanisms of injury require further investigation and medical materials that can protect the lungs from PM2.5 are needed. We have found that Colla corii asini, a traditional Chinese...
journal_title：International journal of molecular sciences
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更新日期：2018-12-23 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-05-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2021-01-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103211
更新日期：2018-10-17 00:00:00
