Abstract：
:This review focuses on the role of 5'-activated protein kinase (AMPK) in the effects of resveratrol (RSV) and some RSV derivatives on hepatic steatosis. In vitro studies, performed in different hepatic cell models, have demonstrated that RSV is effective in preventing liver TG accumulation by activating AMPK, due to its phosphorylation. These preventive effects have been confirmed in studies conducted in animal models, such as mice and rats, by administering the phenolic compound at the same time as the diet which induces TG accumulation in liver. The literature also includes studies focused on other type of models, such as animals showing alcohol-induced steatosis or even steatosis induced by administering chemical products. In addition to the preventive effects of RSV on hepatic steatosis, other studies have demonstrated that it can alleviate previously developed liver steatosis, thus its role as a therapeutic tool has been proposed. The implication of AMPK in the delipidating effects of RSV in in vivo models has also been demonstrated.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Trepiana J,Milton-Laskibar I,Gómez-Zorita S,Eseberri I,González M,Fernández-Quintela A,Portillo MPdoi
10.3390/ijms19113473subject
Has Abstractpub_date
2018-11-05 00:00:00issue
11issn
1422-0067pii
ijms19113473journal_volume
19pub_type
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